| Skye Pie's Softplay Ltd | Education | 2016 |
| Skylark Garden Design Ltd | Administrative & support | 2022 |
| Skyline Private Hire Ltd | Transport & logistics | 2019 |
| Skyway Properties Ltd | Real estate | 2024 |
| SLA Employment Solutions Ltd | Administrative & support | 2010 |
| Sledgehammer Engineering Press Limited | Wholesale & retail | 2008 |
| Sleevies Ltd | Wholesale & retail | 2023 |
| Slimlite Group Limited | Manufacturing | 2024 |
| SLM Aesthetics Limited | Health & social care | 2022 |
| SLP Packaging Solutions LLP | | 2014 |
| SLP Print Limited | Manufacturing | 2007 |
| SLS Global Limited | Transport & logistics | 2017 |
| SLS IT Recruitment Limited | Administrative & support | 2019 |
| SLV Brickwork Ltd | Construction | 2018 |
| SLV Group Ltd | Financial services | 2021 |
| SLV Plant Hire Ltd | Administrative & support | 2021 |
| SM Construction Craven Ltd | Construction | 2020 |
| Small World Cultural Arts Collective | Education | 2003 |
| Small World Nursery (Northern) Limited | Health & social care | 2024 |
| Smalltheatrehaiga Limited | Professional & scientific | 2024 |
| Smart 4 Homes Limited | Transport & logistics | 2004 |
| Smart 4 Investments Limited | Real estate | 2024 |
| Smart Clothing (Yorkshire) Ltd | Wholesale & retail | 2023 |
| Smart Display & Exhibitions Ltd | Administrative & support | 2015 |
| Smart Exhibition Storage Limited | Administrative & support | 2022 |
| Smart Healthcare & Diagnostics Ltd | Health & social care | 2019 |
| Smart Hire Taxi Ltd | Administrative & support | 2025 |
| Smart Home Appliances Limited | Wholesale & retail | 2023 |
| Smart Printworks Limited | Extraterritorial | 2017 |
| Smartappliancesuk Limited | Wholesale & retail | 2018 |
| Smartfynd Essentials Ltd | Wholesale & retail | 2025 |
| Smartgenix Limited | Information & communication | 2022 |
| Smile Compare International Limited | Information & communication | 2026 |
| Smilespecialist Ltd | Professional & scientific | 2013 |
| Smily's Super Whip Ltd | Manufacturing | 2026 |
| Smith & Rhodes Ltd | Manufacturing | 2014 |
| SMO25 Ltd | Education | 2025 |
| Smoulden Properties Limited | Real estate | 1989 |
| SMS Workshop Supplies Limited | Wholesale & retail | 2008 |
| SMT (Staff Management Tools) Limited | Professional & scientific | 1995 |
| SN Marketing Services Ltd | Other services | 2009 |
| Snapthis Entertainment Ltd | Administrative & support | 2026 |
| Snaygill Boats Limited | Transport & logistics | 1972 |
| Snell Construction LLP | | 2004 |
| Snell Group Limited | Professional & scientific | 2000 |
| SNG Fire Ltd | Information & communication | 2012 |
| SNG Logistics (UK) Ltd | Transport & logistics | 2003 |
| Snkrz N Garmz Ltd | Wholesale & retail | 2022 |
| Snobs Property Group Ltd | Real estate | 2024 |
| Snoozy Nights International Ltd | Manufacturing | 2025 |
| Snowdan Limited | Real estate | 2024 |
| SNT Tavens Ltd | Hospitality | 2025 |
| Softey Limited | Wholesale & retail | 2023 |
| Solar Boost Ltd | Construction | 2016 |
| Solara Group UK Ltd | Construction | 2025 |
| Solartonic Energy Ltd | Professional & scientific | 2024 |
| Solution Coffee Ltd | Hospitality | 2024 |
| Solvix Group Ltd | Wholesale & retail | 2025 |
| Sortsell Ltd | Wholesale & retail | 2023 |
| Soul Climb Limited | Professional & scientific | 2026 |
| Souls in Stone Ltd | Other services | 2025 |
| Sound Legal Minds Ltd | Professional & scientific | 2022 |
| Sound of Change CIC | Information & communication | 2025 |
| South Craven Academy Trust | Education | 2011 |
| South Craven Energy Limited | Energy | 2016 |
| South Craven Properties Limited | Real estate | 2026 |
| South Street Metals LLP | | 2006 |
| Southams of Haworth Limited | Wholesale & retail | 1956 |
| Sowdens Keighley Limited | Wholesale & retail | 2010 |
| SP Vision Ltd | Health & social care | 2020 |
| Spa Nails HC Ltd | Other services | 2026 |
| SPACE3 Creative Ltd | Administrative & support | 2008 |
| Spadgers Ltd | Wholesale & retail | 2017 |
| Spartan Consultants Limited | Information & communication | 2010 |
| SPB Services Limited | Professional & scientific | 2006 |
| Speake Medley Holdings Limited | Real estate | 2001 |
| Speartip Media Limited | Professional & scientific | 2025 |
| Specialist Ducting Supplies Limited | Wholesale & retail | 1983 |
| Specialist Project Integration Ltd | Construction | 2008 |
| Speed Hire Solutions Ltd | Other services | 2013 |
| Speedline Private Hire Limited | Transport & logistics | 2016 |
| Spellsound Limited | Manufacturing | 1999 |
| Spencer Fabrications Limited | Manufacturing | 2011 |
| Spencer Motors Limited | Wholesale & retail | 2003 |
| Spice Essence Limited | Hospitality | 2013 |
| Sport Insight Solutions Limited | Information & communication | 2024 |
| Sportivation Sports Coaching Ltd | Education | 2018 |
| Spot on Theatre Services Limited | Construction | 2004 |
| Sprayden Designs Ltd | Professional & scientific | 2026 |
| Springbok Landscapes Ltd | Administrative & support | 2023 |
| Springfield Cleaning Limited | Administrative & support | 2018 |
| Springfield Mill Motors Ltd | Wholesale & retail | 2022 |
| Springfield Motors Limited | Wholesale & retail | 2019 |
| SQB Holdings Ltd | Real estate | 2025 |
| Sqhussain Ltd | Health & social care | 2016 |
| Square Circle Bars Limited | Hospitality | 2024 |
| Square PEG AM Limited | Wholesale & retail | 2018 |
| Squashed Pixel Limited | Information & communication | 2009 |
| SR & AH Properties Ltd | Real estate | 2025 |
| SR & WP Brewster Properties Ltd | Real estate | 2017 |