| S3 Retails Ltd | Wholesale & retail | 2026 |
| SA Home Maintenance Ltd | Construction | 2022 |
| Saads Cards Ltd | Wholesale & retail | 2026 |
| Saela Optical Services Ltd | Other services | 2010 |
| Safa Assets Ltd | Real estate | 2022 |
| Safe Environment (Surveys) Ltd | Professional & scientific | 2025 |
| Safe Environment (UK) Ltd | Professional & scientific | 2012 |
| Safe Steps Training Ltd | Education | 2025 |
| Safecast Limited | Information & communication | 2013 |
| Sagars 365 Limited | Manufacturing | 2012 |
| Sagewood Publishing Ltd | Information & communication | 2016 |
| Saghir Limited | Financial services | 2013 |
| Sajad Consultants Limited | Financial services | 2017 |
| Salazon Limited | Wholesale & retail | 2023 |
| Saldi Ltd | Professional & scientific | 2020 |
| Sales Universal Limited | Wholesale & retail | 2015 |
| Sals Streetfood Limited | Hospitality | 2025 |
| Salt's Village Bakery Limited | Wholesale & retail | 1999 |
| Saltaire Properties 2001 Limited | Real estate | 2001 |
| Saltaire Training Company Ltd | Education | 2018 |
| Salvus Broking Group Limited | Financial services | 2026 |
| Sam's Pizza Cowling Limited | Hospitality | 2021 |
| Samiul Construction Ltd | Construction | 2021 |
| Sami’S Care Services Ltd | Health & social care | 2025 |
| Sammy Autos Limited | Wholesale & retail | 2026 |
| Samstar Solutions Limited | Information & communication | 2023 |
| Sana's Care Services Ltd | Health & social care | 2025 |
| Sanaa a Housing Ltd | Real estate | 2025 |
| Sanctum Healthcare Direct Ltd | Health & social care | 2025 |
| Sand Street Autos Limited | Wholesale & retail | 2014 |
| Sand Street Logistics Ltd | Transport & logistics | 2025 |
| Sanderson Electrics Limited | Manufacturing | 1974 |
| Sanderson IP Limited | Professional & scientific | 2013 |
| Sands Wear Ltd | Wholesale & retail | 2026 |
| Sangat Community Association | Health & social care | 1999 |
| Sani LA Sani Travel & Tours Ltd | Administrative & support | 2011 |
| Sapient Medical Consults Ltd | Health & social care | 2024 |
| Sapling Properties Group Ltd | Real estate | 2018 |
| SAR Investment Properties Ltd | Real estate | 2023 |
| SAR Property Management Ltd | Real estate | 2023 |
| Sarah Farrar Ltd | Wholesale & retail | 2015 |
| Sarah Sufi Trading Company Ltd | Wholesale & retail | 2025 |
| Sartorial Thrifts Ltd | Wholesale & retail | 2026 |
| SAS Electrical (Yorkshire) Limited | Construction | 2021 |
| SAS Projects Ltd | Construction | 2018 |
| Sasas Bakes Limited | Wholesale & retail | 2024 |
| Sattar Shah Courier Ltd | Transport & logistics | 2026 |
| SAW Building Services (Yorkshire) Limited | Construction | 2015 |
| SBH Supplies Limited | Wholesale & retail | 2025 |
| Sbutterfield Consulting Ltd | Professional & scientific | 2024 |
| Scalex Trading Ltd | Wholesale & retail | 2025 |
| Scarlet Opus Limited | Professional & scientific | 2007 |
| Scarlett's DRY Cleaning Service Limited | Other services | 2025 |
| Scartop Developments Ltd | Construction | 2024 |
| Scbim Ltd | Professional & scientific | 2025 |
| Schf H2O Ltd | Water & waste | 2019 |
| Scho's Doughs Ltd | Hospitality | 2024 |
| Scholars Way Riddlesden Limited | Households | 2004 |
| Scissor Hands UK Limited | Arts & recreation | 2008 |
| Scorpion Identity Ltd | Wholesale & retail | 2013 |
| Scott Janitorial Supplies Limited | Wholesale & retail | 1985 |
| Scott Joseph Pilling Ltd | Extraterritorial | 2022 |
| Screw Loose Orthopaedics Limited | Professional & scientific | 2025 |
| SCT Transport Services Limited | Other services | 2015 |
| Sd&Pm Ltd | Transport & logistics | 2023 |
| SDL Scaffolding Ltd | Construction | 2016 |
| SDM Interior Design & Decoration Limited | Construction | 2008 |
| SDR + Limited | Wholesale & retail | 2024 |
| SDS International Ltd. | Financial services | 1990 |
| SE PM Ltd | Construction | 2023 |
| Seabuddy Ltd | Extraterritorial | 2023 |
| Seasons for Coffee Limited | Wholesale & retail | 2010 |
| Second Decade Ltd | Hospitality | 2025 |
| Securetech Recycling Ltd | Information & communication | 2020 |
| Sedge Holdings Limited | Professional & scientific | 2015 |
| Sedge Properties Limited | Real estate | 2013 |
| Sedge Trading Limited | Wholesale & retail | 2026 |
| Seerah Tours Ltd | Administrative & support | 2016 |
| Seismal Limited | Financial services | 2013 |
| Selecao Ltd | Wholesale & retail | 2010 |
| Seleco's Limited | Real estate | 1991 |
| Selective Mortgages Limited | Financial services | 2002 |
| Selezionato Limited | Wholesale & retail | 2020 |
| Selinger GI Services Ltd | Health & social care | 2018 |
| Sell UP and Move on Ltd | Wholesale & retail | 2020 |
| SEM Tech (UK) Limited | Wholesale & retail | 2014 |
| Sequoia Books Ltd | Administrative & support | 2019 |
| Serena Developments Limited | Construction | 2021 |
| Serenvale Health Limited | Health & social care | 2026 |
| Serious Media Limited | Information & communication | 1998 |
| Sermonté Ltd | Wholesale & retail | 2026 |
| Serve Local Limited | Wholesale & retail | 2024 |
| Servexa Group Ltd | Professional & scientific | 2026 |
| Service 2 (Hvac) Group Limited | Construction | 2017 |
| Service 2 (Hvac) Holdings Limited | Real estate | 2017 |
| Service 2 (Hvac) Installations Limited | Construction | 2017 |
| Service 2 (Hvac) Limited | Construction | 2011 |
| Service 2 (M&E) Limited | Manufacturing | 2017 |
| Service 2 (Professional Services) Limited | Professional & scientific | 2021 |
| Service Smith Pro Ltd | Professional & scientific | 2026 |