| R2A Services Ltd | Manufacturing | 2025 |
| Raising Standards Consultancy Ltd | Professional & scientific | 2021 |
| Raistand Education Limited | Education | 2025 |
| RAM Enterprise NE Ltd | Wholesale & retail | 2024 |
| Ransu Limited | Professional & scientific | 2009 |
| RD PMC Limited | Construction | 2026 |
| Red Gorgon Ltd | Construction | 2019 |
| Reliance Property Services NE Ltd | Real estate | 2020 |
| Remediation Facade Solutions Ltd | Construction | 2023 |
| Replenish Collagen Ltd | Wholesale & retail | 2021 |
| Rescue POD Training Solutions Ltd | Professional & scientific | 2019 |
| Rescue YOU Rescue ME CIC | Education | 2026 |
| Richmond Welding Ltd. | Manufacturing | 2016 |
| Riva Property Limited | Real estate | 2026 |
| RJ Global Holdings Ltd | Wholesale & retail | 2026 |
| RJG Property Group Limited | Real estate | 2025 |
| RK (NE) Ltd | Real estate | 2024 |
| RM Commercial Diving Limited | Construction | 2013 |
| RMK Elevate (England) Limited | Administrative & support | 2021 |
| Robinson and Co, Bathrooms and Heating Ltd | Construction | 2023 |
| Robinson Bathrooms and Heating Ltd | Construction | 2018 |
| Rokstok Ltd | Professional & scientific | 2021 |
| Roof Proof Ltd | Construction | 2026 |
| Rory Taylor Investments Ltd | Construction | 2025 |
| Rosewood Bespoke Homes Ltd | Construction | 2017 |
| Rotec Industrial Rubber Products Limited | Manufacturing | 2001 |
| RP Fire Door Installations Ltd | Construction | 2023 |
| RPS Refrigeration Limited | Construction | 2024 |
| RRC Wind Ltd | Professional & scientific | 2023 |
| Rumodo Ltd | Professional & scientific | 2021 |
| Rush Asset Integrity Ltd | Information & communication | 2019 |
| RW Access NE Ltd | Energy | 2025 |
| S & G Electrical (NE) Ltd | Construction | 2018 |
| S & I Property Maintenance Ltd | Construction | 2020 |
| S and G Fabrications Limited | Construction | 2019 |
| S Fleming Limited | Wholesale & retail | 2007 |
| S Jones Surveying Ltd | Professional & scientific | 2021 |
| S&L Fleming Limited | Wholesale & retail | 2018 |
| S.A.E.C.L Ltd | Construction | 2025 |
| S1UK Ltd | Other services | 2024 |
| Safe-Line Marine After Sales Ltd | Manufacturing | 2003 |
| Sallyport House Management Limited | Households | 2003 |
| Sambuca Ebold Limited | Hospitality | 2020 |
| Samuel Grant (North East) Limited | Wholesale & retail | 1984 |
| Sandown (Whitley Bay) Management Limited | Households | 1992 |
| Santino's Jarrow Ltd | Hospitality | 2025 |
| Sapphire Ice Property Development Ltd | Real estate | 2024 |
| Saraniya Ltd | Wholesale & retail | 2020 |
| Sawyer Mechanical Services Ltd | Construction | 2024 |
| Saxseat Ltd | Manufacturing | 2024 |
| SB Precision Engineering NE Ltd | Other services | 2017 |
| SB1977 Limited | Households | 2026 |
| Sbht Heat Ltd | Wholesale & retail | 2024 |
| SC Wind Ltd | Administrative & support | 2022 |
| SD Direct Ltd | Wholesale & retail | 2023 |
| Seaclear Inspections Ltd | Professional & scientific | 2018 |
| Seacrest Court Maintenance Limited | Households | 1999 |
| SEE IT Social Ltd | Professional & scientific | 2026 |
| Serelune Ltd | Wholesale & retail | 2025 |
| Serenity H2O Ltd | Wholesale & retail | 2019 |
| Shaun Sadler Holdings Limited | Financial services | 2012 |
| Shenor Engineering Services Limited | | 1978 |
| Shippen Elevator Services Ltd | Professional & scientific | 2025 |
| Short Property Group Ltd | Real estate | 2025 |
| Shun Property Limited | Real estate | 2020 |
| SI Global Trading Limited | Wholesale & retail | 2022 |
| Sigma Renewable Energy Ltd | Manufacturing | 2021 |
| Silver Lady UK Limited | Real estate | 2017 |
| Silvergate Mortgages Ltd | Financial services | 2013 |
| Silvergate Wills Limited | Professional & scientific | 2017 |
| Simco (Engineers) Group Limited | Financial services | 2025 |
| Simco (Engineers) Investment Limited | Financial services | 2025 |
| Simco (Engineers) Limited | Manufacturing | 1973 |
| Simco Supply Co. Limited | Extraterritorial | 1982 |
| Simply Certification Limited | Professional & scientific | 2020 |
| Simply Kindra Limited | Administrative & support | 2025 |
| Simply Learning Limited | Education | 2002 |
| Sitaram Enterprise NE Ltd | Wholesale & retail | 2026 |
| Six&Four Studio Ltd | Professional & scientific | 2024 |
| SJN QS Consulting Limited | Administrative & support | 2011 |
| SJW Electrical Contractors (N.E.) Limited | Construction | 2013 |
| Skin MED Aesthetic Clinic Ltd | Other services | 2023 |
| Smart Shop Jarrow Limited | Wholesale & retail | 2025 |
| SME Enterprise Skills Ltd | Education | 2025 |
| Smile Happy NE Limited | Other services | 2015 |
| Snee Consulting Limited | Information & communication | 2024 |
| Social Work Training and Assessments Ltd | Health & social care | 2018 |
| Solar Glass NE Ltd | Construction | 2019 |
| Sole Associates Ltd | Administrative & support | 2022 |
| Solutions DE Corde Ltd | Construction | 2018 |
| Soneic Solar Services Limited | Other services | 2011 |
| South Shields Football Club 1888 Limited | Arts & recreation | 2015 |
| South Shields Physiotherapy Ltd | Other services | 2020 |
| South Tyne Electrical Solutions Ltd | Construction | 2025 |
| South Tyneside Decor Limited | Wholesale & retail | 2009 |
| South Tyneside Property Limited | Real estate | 2019 |
| Southbank Communications Ltd | Professional & scientific | 2019 |
| Spec Global Ltd | Wholesale & retail | 2025 |
| Spectrum Event Production Limited | Administrative & support | 2019 |
| Spectrum Industrial Limited | Manufacturing | 1976 |