| Night Time Golf Ltd | Hospitality | 2021 |
| Nippers Property Holding Ltd | Real estate | 2026 |
| NMA Investments Ltd | Real estate | 2026 |
| Nnam Group Ltd | Information & communication | 2024 |
| Norast Limited | Manufacturing | 2011 |
| Norouzi Visuals Ltd | Information & communication | 2025 |
| North East Cleaning Services Ltd | Administrative & support | 2021 |
| North East EAR Clinic Ltd | Health & social care | 2018 |
| North East Industrial Services Limited | Construction | 2026 |
| North East Printing Solutions Limited | Manufacturing | 2026 |
| North East Sports Academy Ltd | Education | 2025 |
| North East Winders Ltd | Construction | 2023 |
| Northeast Bespoke Bedrooms Ltd | Construction | 2025 |
| Northeast Starlight Property Ltd | Real estate | 2023 |
| Northern Canopy CIC | Agriculture & fishing | 2025 |
| Northern Moving Services Limited | Administrative & support | 2002 |
| Northern Vape Limited | Wholesale & retail | 2017 |
| Northumberland Park Property Development Ltd | Real estate | 2021 |
| Notwen Limited | Other services | 2013 |
| Oakwrench Holdings Ltd | Real estate | 2020 |
| Oakwrench Properties Ltd | Real estate | 2019 |
| Odin Sea Ltd | Education | 2020 |
| Officiency I.T. Networks Limited | Information & communication | 2018 |
| OIL and GAS Structural Engineering Consultants Limited | Professional & scientific | 2022 |
| OIS Inspection Ltd | Manufacturing | 2022 |
| One Punch UK United Ltd | Health & social care | 2015 |
| One SIX Eight Company Holdings Limited | Professional & scientific | 2024 |
| One Stop Windows (NE) Limited | Construction | 2013 |
| Online Edinburgh Limited | Real estate | 1996 |
| Only Sofia Ltd | Arts & recreation | 2022 |
| Optica EYE Clinic (Jarrow) Limited | Wholesale & retail | 2014 |
| Optica EYE Clinic (Wallsend) Limited | Wholesale & retail | 2014 |
| Optimising Property Ltd | Real estate | 2025 |
| ORA Property Services Limited | Construction | 2005 |
| Originalhuman Entertainment Ltd | Information & communication | 2023 |
| Orsan Limited | Real estate | 2015 |
| OUT and About North East Community Interest Company | Health & social care | 2025 |
| Outsource Central Ltd | Administrative & support | 2023 |
| P&J Ropes Ltd | Administrative & support | 2026 |
| P&L Cleaning Services Ltd | Administrative & support | 2021 |
| Pacer Rail Ltd | Construction | 2019 |
| Parker's Property Portfolio Limited | Real estate | 2017 |
| Pars NE Limited | Hospitality | 2025 |
| Party Peace App Ltd | Information & communication | 2025 |
| PAS Access Ltd | Construction | 2024 |
| Paul Data Limited | Information & communication | 2024 |
| Pauls Pipeline Projects Ltd | Construction | 2025 |
| Paxs Secure Ltd | Manufacturing | 2025 |
| PC Counselling and Supervision Ltd | Health & social care | 2021 |
| PC Counselling and Training Limited | Education | 2016 |
| Pcct Ltd | Education | 2022 |
| PCS Training CIC | Education | 2019 |
| PDC Electrical NE Ltd | Construction | 2018 |
| Peach Care Services North Ltd | Public administration | 2025 |
| Peaktop Glazing Ltd | Construction | 2025 |
| Pearl Cottage Takeaway Ltd | Hospitality | 2018 |
| Pearson Civil Engineering Ltd | Construction | 2012 |
| Pearson QS Ltd | Construction | 2026 |
| Pearson Solutions Ltd | Construction | 2025 |
| PEDROK72 Limited | Professional & scientific | 2017 |
| Peerless Establishment Limited | Financial services | 2018 |
| Pennguin Limited | Wholesale & retail | 2010 |
| Penshaw Manor Property Management Limited | Real estate | 2004 |
| Phantom Fishing Rods Ltd | Wholesale & retail | 2024 |
| Phoenix Machining Ltd | Manufacturing | 2009 |
| Pillar Construction NE Ltd | Construction | 2026 |
| Pizza Cottage (Newcastle) Limited | Hospitality | 2017 |
| Pizza XL NCL Ltd | Hospitality | 2025 |
| PL8 King Number Plates Ltd | Wholesale & retail | 2020 |
| PNE Group Ltd | Real estate | 2025 |
| Powerline (NE) Limited | Construction | 2018 |
| Pratt Construction Group Limited | Construction | 2025 |
| Prefix Technology Ltd | Information & communication | 2025 |
| Premarv Properties Ltd | Real estate | 2025 |
| Premier Express Jarrow Ltd | Wholesale & retail | 2026 |
| Premier NE2 Ltd | Wholesale & retail | 2019 |
| Primrose Community Association | Other services | 2013 |
| Primrose Community Enterprises Ltd | Arts & recreation | 2013 |
| Print Prodigy Ltd | Manufacturing | 2023 |
| Private World Collection Ltd | Health & social care | 2026 |
| Pro Part Automotive Ltd | Wholesale & retail | 2015 |
| Pro Vent LEV Ltd | Manufacturing | 2025 |
| Pro-Point North East Ltd | Construction | 2026 |
| Promethean Flame Productions Ltd | Information & communication | 2010 |
| Property Talk Holdings Ltd | Financial services | 2025 |
| Property Talk Investments Ltd | Professional & scientific | 2020 |
| Property Talk Lettings Ltd | Real estate | 2023 |
| Property Talk Management Ltd | Real estate | 2021 |
| Property Talk PM Ltd | Real estate | 2025 |
| Ptmd Limited | Financial services | 2024 |
| PW Holdings (North East) Limited | Financial services | 2023 |
| Qmusic Ltd | Wholesale & retail | 2018 |
| Quadrus Accountancy Limited | Professional & scientific | 2017 |
| Qualo Installations Ltd | Construction | 2026 |
| Quantum Commercial Management Services Ltd | Professional & scientific | 2016 |
| Qubain Properties Limited | Real estate | 2022 |
| Qubocorp Ltd | Wholesale & retail | 2016 |
| R and B Real Estate Limited | Real estate | 2026 |
| R and P Ceramics Ltd | Water & waste | 2016 |
| R&Jc Properties Ltd | Real estate | 2025 |