| R D Services South West Limited | Construction | 2020 |
| R Perks Finance & Accountancy Limited | Professional & scientific | 2024 |
| R W Autos SW Ltd | Wholesale & retail | 2025 |
| R W Removal Ltd | Transport & logistics | 2024 |
| R. H. Mechanical Servicing Ltd. | Wholesale & retail | 2015 |
| R1 Property Services SW Ltd | Real estate | 2025 |
| R1 Services (SW) Ltd | Wholesale & retail | 2021 |
| R2 Services (SW) Ltd | Wholesale & retail | 2022 |
| Raffles (SW) Ltd | Hospitality | 2023 |
| Rakkit Ltd | Manufacturing | 2024 |
| Rapid Iterations Ltd | Professional & scientific | 2024 |
| Rare & Pasture Limited | Wholesale & retail | 2020 |
| RAY Hannaford and SON Ltd | Construction | 2020 |
| Rayon Medical Writing Ltd | Health & social care | 2024 |
| RB Domestics Ltd | Construction | 2025 |
| RC Construction & Scaffolding Ltd | Construction | 2018 |
| RC Scaffolding (SW) Ltd | Construction | 2022 |
| RC Sealants Limited | Construction | 2024 |
| RCR Flooring Products Limited | Manufacturing | 1993 |
| Reactive Watersports Company Limited | Wholesale & retail | 1996 |
| Reade the Room Ltd | Construction | 2025 |
| Reball Ltd. | Arts & recreation | 2023 |
| Reblou Southwest Limited | Hospitality | 2021 |
| Redwoods Carpentry Ltd | Extraterritorial | 2019 |
| Reecegallen Ltd | Wholesale & retail | 2025 |
| Refine Beauty Salon Limited | Real estate | 2024 |
| Refine Hair Salon Ltd | Other services | 2023 |
| REM Medical Services Limited | Health & social care | 2024 |
| Remedy Adventures Limited | Administrative & support | 2019 |
| Remote Working Ltd | Information & communication | 2020 |
| Renewables South West Limited | Construction | 2023 |
| Reverie Film Productions Ltd | Information & communication | 2021 |
| Revival Roofing Limited | Construction | 2022 |
| Revolution Wheel Refurbishment (Devon) Limited | Wholesale & retail | 2025 |
| RG Industrial Heating Limited | Construction | 2007 |
| RGL Construction SW Ltd | Construction | 2024 |
| RH Media Limited | Information & communication | 2025 |
| Ribbon and Cloth Productions Ltd | Arts & recreation | 2025 |
| Richard Ayers Ltd | Professional & scientific | 2004 |
| Richard J Smith & Co LLP | | 2016 |
| Richard Ough Plumbing and Heating Limited | Construction | 2020 |
| Riverbridge Interiors Ltd | Manufacturing | 2019 |
| RJT Drainage Ltd | Water & waste | 2024 |
| RN Marine Engineering Limited | Professional & scientific | 2026 |
| Roar Films Limited | Information & communication | 2012 |
| Robertaccinipmc Limited | Wholesale & retail | 2013 |
| Robopets Limited | Wholesale & retail | 2020 |
| Roborough Trade Centre Limited | Wholesale & retail | 2026 |
| Rock Cottage Plymouth Ltd | Hospitality | 2023 |
| Rockshore Carpentry & Framing Limited | Manufacturing | 2019 |
| Roofline Fascias Limited | Construction | 2003 |
| Ross Reliable Ltd | Construction | 2013 |
| Rowlands Attractions Ltd | Arts & recreation | 2025 |
| Rowlands Events Limited | Administrative & support | 2021 |
| RSR Properties SW Limited | Real estate | 2026 |
| RSR Property Management Limited | Households | 2026 |
| Rusty PIG Limited | Hospitality | 2012 |
| Ryeland Properties Limited | Real estate | 2017 |
| S & J Fisheries Limited | Wholesale & retail | 1998 |
| S & J Holdings Ltd | Real estate | 2017 |
| S B Composites Ltd | Manufacturing | 2024 |
| S C Plastering SW Ltd | Construction | 2023 |
| S Williams Engineering Ltd | Professional & scientific | 2015 |
| Salcombe Home Services Ltd | Households | 2020 |
| Salt Catering Co Ltd | Hospitality | 2024 |
| Samrose Property Limited | Real estate | 2018 |
| Samsara Fabrics Ltd | Wholesale & retail | 2024 |
| SBC Carpentry Ltd | Construction | 2025 |
| SBC Construction Ltd | Construction | 2023 |
| Scamfree Limited | Information & communication | 2000 |
| Scarlet Velvet Ltd | Wholesale & retail | 2022 |
| Scinola Ltd | Wholesale & retail | 2018 |
| Scruffs Limited | Arts & recreation | 2019 |
| Sea International Consulting Ltd | Professional & scientific | 2016 |
| Sea N Shore Ltd | Transport & logistics | 2010 |
| Seabarn Management Limited | Financial services | 2017 |
| Seabarn Management Services Limited | Administrative & support | 2022 |
| Seabarn Properties Poole Limited | Real estate | 2020 |
| Seabarn Retreat Limited | Hospitality | 2022 |
| Seabarn Works Limited | Hospitality | 2019 |
| Seadog Maritime Solutions Limited | Public administration | 2023 |
| Seaway Insurance Consultants (GI) Limited | Financial services | 2001 |
| Second Bloom Limited | Wholesale & retail | 2024 |
| Secret Greek Ltd | Hospitality | 2023 |
| Sentinel House Modbury Limited | Households | 2020 |
| Serotonin Studio Ltd | Education | 2024 |
| Severnside Provisions Limited | Wholesale & retail | 1991 |
| SFG Financial Management Ltd | Professional & scientific | 2012 |
| SFS Drywall Limited | Construction | 2022 |
| Shared Truth Ltd | Health & social care | 2025 |
| Shave and SON Electrical Ltd | Construction | 2026 |
| SHD Medical Limited | Wholesale & retail | 2014 |
| Shell and Grape Ltd | Manufacturing | 2024 |
| Shepherd's Bush Cheese Company Ltd | Wholesale & retail | 2025 |
| Sherlocks Emporium Ltd | Wholesale & retail | 2025 |
| Shilstone (Devon) Limited | Real estate | 1997 |
| Shilstone Devon Holding Company Limited | Financial services | 2025 |
| Shilstone Investment Company Limited | Financial services | 2025 |
| Shilstone Secondary Investment Company Limited | Real estate | 2025 |
| Ship Properties Limited | Real estate | 2025 |