| Option Ltd | Wholesale & retail | 2025 |
| OR Business Consulting Limited | Information & communication | 2016 |
| ORA Property and Lettings Limited | Real estate | 2016 |
| Orbital Properties SW Ltd | Real estate | 2025 |
| Orchard House Consultancy Limited | Professional & scientific | 2026 |
| Orchard Park Management Company (Ivybridge) Limited | Households | 2003 |
| Origination and Print Limited | Information & communication | 2020 |
| Otter Ecology Ltd | Professional & scientific | 2025 |
| Outsourced Tax Partner Ltd | Professional & scientific | 2020 |
| P & G Property Ventures Ltd | Real estate | 2024 |
| P C Maritime Limited | Information & communication | 1988 |
| P J Goddard Limited | Financial services | 2018 |
| P&J Cards Ltd | Transport & logistics | 2026 |
| Panda Wellbeing Clinic Ltd | Health & social care | 2026 |
| Pantheon Avon Mill Ltd | Arts & recreation | 2023 |
| Panther Breaks Ltd | Arts & recreation | 2026 |
| Parent Carer Forum Devon C.I.C. | Information & communication | 2021 |
| Parklife Properties SW Limited | Real estate | 2026 |
| Parson Funerals Limited | Other services | 2020 |
| Patrick Wakeley Plumbing & Heating Ltd | Construction | 2002 |
| Pattinson's & Dart Bricklaying Services Ltd. | Construction | 2018 |
| Paws & Listen Ltd | Extraterritorial | 2024 |
| PB Properties SW Ltd | Real estate | 2026 |
| PC Trading SW Ltd | Real estate | 2024 |
| Pearce Brothers Ltd. | Construction | 2017 |
| Penbeacon Limited | Wholesale & retail | 2019 |
| Peninsula Cardiac Imaging Services Limited | Health & social care | 2019 |
| Peninsula Judo Club Limited | Arts & recreation | 2024 |
| Penske Limited | Hospitality | 2007 |
| People at Work Limited | Other services | 1997 |
| PER Goodwin Limited | Professional & scientific | 2018 |
| Percy Williams & Sons,Limited | Construction | 1938 |
| Peri Peri Perfection Ltd | Hospitality | 2026 |
| Petty Remedies Limited | Health & social care | 2025 |
| Peverell Garage Limited | Wholesale & retail | 2003 |
| PGA Aviation Ltd | Professional & scientific | 2020 |
| PHP Groundworks SW Limited | Construction | 2024 |
| Pickle Pictures (UK) Ltd | Information & communication | 2014 |
| Pimperne Steel Fabrications Limited | Professional & scientific | 2019 |
| Pink Mango (SW) Ltd | Wholesale & retail | 2022 |
| Pinnacle Civil Engineering Limited | Construction | 2026 |
| Pipnheather Limited | Households | 2017 |
| Piran Caravans Ltd | Wholesale & retail | 2021 |
| Pittman Trees Ltd | Administrative & support | 2016 |
| Pizaa Loca Ltd | Hospitality | 2021 |
| PL1 Properties Limited | Hospitality | 2021 |
| Plan for Ecology Limited | Professional & scientific | 2019 |
| Plastics in Construction Limited | Construction | 2004 |
| Platinum Accountancy South West Limited | Professional & scientific | 2019 |
| Plym Waste Removals Ltd | Water & waste | 2023 |
| Plymex Property Services Ltd | Other services | 2025 |
| Plymfit Windows and Doors Limited | Construction | 2025 |
| Plymlocks Limited | Manufacturing | 2025 |
| Plymouth Carpets and Flooring Ltd | Wholesale & retail | 2011 |
| Plymouth Glass Gallery Ltd | Wholesale & retail | 2019 |
| Plymouth Heating Solutions Ltd | Construction | 2019 |
| Plymouth Holistic Training Limited | Education | 2025 |
| Plymouth PUB Group Ltd | Hospitality | 2025 |
| Plymouth Scaffolding Ltd | Construction | 2025 |
| Plymouth Scaffolding SW Limited | Construction | 2023 |
| Plymouth Tattoo Removal & Laser Aesthetics Ltd | Other services | 2025 |
| Plymouth Wellbeing Centre Limited | Other services | 2024 |
| Plymstock Commercials Limited | Wholesale & retail | 1999 |
| Plymstock Fish & Chips Ltd | Hospitality | 2025 |
| Plymstock Fish & Chips Trading Ltd | Hospitality | 2026 |
| Plymstock Fish Shop Ltd | Hospitality | 2015 |
| Plymstock Garage Ltd | Wholesale & retail | 2017 |
| Polgannel Solutions Ltd | Wholesale & retail | 2011 |
| Poochies Go Walkies Limited | Other services | 2026 |
| POP Ventures Limited | Households | 2019 |
| Porth Project Finance International Consulting Limited | Professional & scientific | 2014 |
| Precision Edge Research Ltd | Information & communication | 2025 |
| Premier Building Systems Limited | Construction | 2009 |
| Premier Contractors (South West) Limited | Construction | 2007 |
| Prestige Building Systems Ltd | Construction | 2020 |
| PRH Equities Ltd | Real estate | 2025 |
| Pri-Lux Hair & Beauty Ltd | Other services | 2025 |
| Pride Plumbing SW Ltd | Construction | 2025 |
| Primo Business Services Limited | Professional & scientific | 2012 |
| Primus Construction Southwest Limited | Construction | 2025 |
| Pro-Lec Electrical (SW) Ltd | Construction | 2019 |
| Pro-Lec Services (SW) Ltd | Construction | 2023 |
| Pro-Nrg Renewables Ltd | Construction | 2026 |
| Professional Consultancy Ltd | Professional & scientific | 2026 |
| Professional Resource Organisation Limited | Administrative & support | 2020 |
| Property Click International Ltd | Information & communication | 2023 |
| Provenn Ltd | Households | 2011 |
| Prowse Developments Ltd | Construction | 2010 |
| PS Archive Ltd | Wholesale & retail | 2026 |
| PUBCO54 Ltd | Hospitality | 2024 |
| Pugs and Pals Devon Ltd | Other services | 2024 |
| Pugs and Pals Groom Room Ltd | Other services | 2025 |
| Pure GAS & Water Ltd | Construction | 2026 |
| Pushkar Creations Ltd | Wholesale & retail | 2025 |
| Puttock Education Consultancy Ltd | Education | 2026 |
| Q Best Order Limited | Hospitality | 2016 |
| Quantum Roofing SW Limited | Construction | 2026 |
| Quarry Farm Ludbrook Management Company Limited | Households | 2008 |
| R & E-S (Properties) Ltd | Construction | 2020 |
| R C Construction SW Ltd | Administrative & support | 2013 |