| Simply the Zest Ltd | Administrative & support | 2025 |
| SJA SW Ltd | Real estate | 2023 |
| SJE Financial Ltd | Financial services | 2025 |
| Skate South Devon CIC | Education | 2021 |
| SLH Haulage Services Ltd | Professional & scientific | 2025 |
| Smart Move Recovery Limited | Transport & logistics | 2025 |
| Smarta PAY Ltd | Administrative & support | 2025 |
| Smarta Reductions (SW) Ltd | Professional & scientific | 2020 |
| Smashland Foods Ltd | Hospitality | 2024 |
| SMB Utilities Ltd | Construction | 2025 |
| SMC Building Services Ltd | Professional & scientific | 2022 |
| SMF Drainage Limited | Water & waste | 2024 |
| Snug Destinations Limited | Real estate | 2025 |
| Socialights SW Ltd | Administrative & support | 2026 |
| Socit (SW) Ltd | Wholesale & retail | 2022 |
| Solalec Ltd | Construction | 2026 |
| Solidus South West Ltd | Real estate | 2024 |
| Solyco UK Property Spvi Limited | Real estate | 2025 |
| Soper Carpentry & Building Ltd | Manufacturing | 2025 |
| Soren Liva Ltd | Education | 2026 |
| SOS Holdings (SW) Ltd | Professional & scientific | 2023 |
| South Devon & Dartmoor Law Limited | Professional & scientific | 2025 |
| South Devon Gardens Ltd | Administrative & support | 2001 |
| South Devon Osteopaths Limited | Health & social care | 2010 |
| South Devon Roasters Limited | Wholesale & retail | 2010 |
| South Face Garden Care Limited | Real estate | 2023 |
| South Hams Accounting Ltd | Professional & scientific | 2002 |
| South Hams Aesthetics Ltd | Other services | 2025 |
| South Hams Autos Ltd | Wholesale & retail | 2023 |
| South Hams Double Glazing Limited | Construction | 2014 |
| South Hams Fencing Limited | Agriculture & fishing | 2025 |
| South Hams Marine Ltd | Wholesale & retail | 2009 |
| South Hams Physio Ltd | Health & social care | 2011 |
| South Hams Properties Limited | Real estate | 2010 |
| South Hams Tool Hire Limited | Other services | 2002 |
| South West Commercial Cleaning Ltd | Administrative & support | 2022 |
| South West Compactor Services Limited | Manufacturing | 2007 |
| South West Superbikes Ltd | Wholesale & retail | 2020 |
| Southwest Concrete Pumping Limited | Administrative & support | 2018 |
| Southwest Mobile Tyres Limited | Manufacturing | 2025 |
| Southwest Stonemasons Ltd | Construction | 2025 |
| SP Electrical Contractors SW Limited | Construction | 2026 |
| Spinnaker Drive Management Ltd | Real estate | 2020 |
| Spion Lodge Developments Ltd | Construction | 2020 |
| SPM (SW) Investments Ltd | Real estate | 2024 |
| Sport Performance Intelligence Limited | Education | 2024 |
| Spot on Property Management Ltd | Real estate | 2025 |
| Sprs Joinery & Building Ltd | Construction | 2022 |
| Sprucewool Limited | Wholesale & retail | 1981 |
| Spurham Holdings Limited | Financial services | 2020 |
| SR Property Management (SW) Ltd | Real estate | 2022 |
| SRH Contracting Ltd | Construction | 2026 |
| Sritala Thai Massage Limited | Other services | 2024 |
| SSL Therapy Services Ltd | Health & social care | 2012 |
| ST John's Chapel Development Ltd | Real estate | 2022 |
| ST John's Residents Management Limited | Households | 2023 |
| ST Just Property Ltd | Real estate | 2016 |
| ST Power Ltd | Construction | 2022 |
| ST. Mary Street 1965 Limited | Extraterritorial | 2014 |
| Stanleysmith Case Management Ltd | Health & social care | 2018 |
| Start Offshore Ltd | Administrative & support | 2024 |
| Stella Rose Aesthetics Ltd | Other services | 2022 |
| Steritech Consulting UK Limited | Professional & scientific | 2025 |
| Steve Mitchell Limited | Construction | 2002 |
| Steven and Laurent Hairdressers Limited | Other services | 2015 |
| Stonehedge Hold Limited | Financial services | 2024 |
| Storegrow Limited | Real estate | 2003 |
| Stow a Stepladder UK Ltd | Wholesale & retail | 2020 |
| Strashleigh Farm Ltd | Real estate | 2021 |
| Strategically Managed Property Ltd | Real estate | 2019 |
| Streatkitchen Porthleven Ltd | Hospitality | 2009 |
| Superfibre Limited | Hospitality | 1995 |
| Surfs UP! Surf Hire Ltd | Arts & recreation | 2023 |
| Susan E Field Management Accounting Limited | Professional & scientific | 2010 |
| SW Catering Ltd | Hospitality | 2025 |
| SW Financial Planning Limited | Financial services | 1997 |
| SW Law & Finance Limited | Financial services | 2023 |
| Swift Steel Ltd | Construction | 2020 |
| Swim Safe Projects CIC | Other services | 2024 |
| Swing Studios Ltd | Information & communication | 2025 |
| Swlaw Limited | Professional & scientific | 2011 |
| Synergy 1808 Limited | Hospitality | 2000 |
| Synergy 3D Solutions Limited | Professional & scientific | 2023 |
| T Melvin Carpentry and Maintenance Ltd | Construction | 2015 |
| T.R.N.G Ltd | Health & social care | 2012 |
| Tamar Cleaning Services Ltd | Administrative & support | 2020 |
| Tamar Gaming Limited | Administrative & support | 2008 |
| Tamar Holdings Limited | Administrative & support | 2008 |
| Tamar View Dog Groomers Limited | Other services | 2025 |
| Tamarus Surveying Ltd | Professional & scientific | 2026 |
| Taste of Bengal Ivybridge Limited | Hospitality | 2016 |
| Taste of Thailand Market Ltd | Hospitality | 2025 |
| Tayler Talks Ltd | Arts & recreation | 2022 |
| Taylor Made Tonics Limited | Wholesale & retail | 2019 |
| Taylor SW Ltd | Real estate | 2025 |
| TB Maintenance Ltd | Water & waste | 2026 |
| Tbuckingham Ltd | Arts & recreation | 2025 |
| Teachbits Ltd | Information & communication | 2021 |
| Teak Decking Limited | Manufacturing | 2003 |
| Teales Sporting Ltd | Wholesale & retail | 2015 |