| Safe Arrows Properties Ltd | Real estate | 2025 |
| Safe Secure Locker Services Limited | Manufacturing | 2008 |
| Safemate Logic Ltd | Wholesale & retail | 2016 |
| Safescope Limited | Professional & scientific | 2008 |
| Safesteps Traffic Management Ltd | Construction | 2025 |
| Safety in Knowledge Ltd | Health & social care | 2020 |
| Safeway Tyre & Exhaust Centre Ltd | Wholesale & retail | 2011 |
| Safewear DK Ltd | Wholesale & retail | 2026 |
| Safeyos Limited | Hospitality | 2020 |
| Saffron Woodbridge Ltd | Hospitality | 2023 |
| Safl British Hotels Limited | Hospitality | 2017 |
| Safra Consulting Ltd | Information & communication | 2021 |
| Sage Accounts Solutions Ltd | Information & communication | 2007 |
| Sage Surveyors Ltd | Construction | 2017 |
| SAI Asha Ltd | Real estate | 2018 |
| SAI Crown Ltd | Households | 2018 |
| SAI Kiran Ltd | Real estate | 2018 |
| SAI Observation Commercial Ltd | Administrative & support | 2018 |
| SAI Observation Flats Ltd | Real estate | 2018 |
| SAI Observation Ltd | Real estate | 2015 |
| SAI Places Ltd | Real estate | 2016 |
| SAI Trinova Ltd | Real estate | 2025 |
| SAI Vikas Ltd | Real estate | 2018 |
| Sail and Cover Marine Services Ltd | Manufacturing | 2023 |
| Sailawayshaphea Limited | Hospitality | 2026 |
| Sailing Experience Limited | Professional & scientific | 2020 |
| Sailspar Engineering Limited | Manufacturing | 2016 |
| Sailstone Ltd | Construction | 2011 |
| SAJ and Sons Building Ltd | Manufacturing | 2025 |
| Sakeenah Ltd | Health & social care | 2018 |
| Sakura Sports Limited | Administrative & support | 2017 |
| Salaam Property Limited | Construction | 2023 |
| Salah EL Brogy Company Limited | Arts & recreation | 2013 |
| Salami Deli Ltd | Wholesale & retail | 2015 |
| Salfs Ipswich Ltd | Transport & logistics | 2022 |
| Salfs Security Ltd | Administrative & support | 2025 |
| Salfs Training Ltd | Education | 2026 |
| Salih Mehmed Ltd | Transport & logistics | 2012 |
| Salisbury Property (Essex) LLP | | 2024 |
| Sally Shorten Ltd | Professional & scientific | 2016 |
| Salmon Contractors Ltd | Construction | 2020 |
| Salon by the Bridge Ltd | Other services | 2018 |
| Salon IPS Ltd | Other services | 2019 |
| Salon Life Ltd | Other services | 2024 |
| Saltpeter Wines Ltd | Wholesale & retail | 2020 |
| SAM Lighting Limited | Construction | 2023 |
| SAM Oldham Limited | Arts & recreation | 2012 |
| SAM Peet Illustration Ltd | Arts & recreation | 2022 |
| Saman Hand Car Wash Ltd | Other services | 2020 |
| Samarth Properties Ltd | Real estate | 2025 |
| Same Day Business Loans Limited | Financial services | 2023 |
| Samford Associates Limited | Professional & scientific | 2017 |
| Samford Enterprises Limited | Construction | 2001 |
| Sami Cars Ltd | Wholesale & retail | 2025 |
| Samir Trading Ipswich Limited | Wholesale & retail | 2018 |
| Sampradaa Sukha Academy Ltd | Arts & recreation | 2023 |
| Samyam Distributors Limited | Wholesale & retail | 2024 |
| Sanavar Ltd | Real estate | 2021 |
| Sancon Logistics Ltd | Transport & logistics | 2019 |
| Sanctuary Nexus Ltd | Wholesale & retail | 2020 |
| Sanctuary Personnel II Limited | Extraterritorial | 2019 |
| Sanctuary Personnel Limited | Administrative & support | 2006 |
| Sanctum Halo Ltd | Construction | 2025 |
| Sandeez Ltd | Real estate | 2025 |
| Sanders MAG & Co Ltd | Health & social care | 2017 |
| Sanders Project Management Limited | Construction | 2014 |
| Sandford of London Limited | Extraterritorial | 2015 |
| Sandhurst Avenue Limited | Households | 2004 |
| Sandlings Properties Limited | Extraterritorial | 2017 |
| Sandskill Limited | Construction | 2004 |
| Sandtech Solutions Limited | Information & communication | 2021 |
| Sandu Trasport Ltd | Administrative & support | 2024 |
| Sandy Hill Cars Ltd | Wholesale & retail | 2020 |
| Sandy Sweets Ltd | Wholesale & retail | 2024 |
| Sangster (EA) Ltd | Health & social care | 2017 |
| Sano UK Powered Stairclimbers Limited | Manufacturing | 2003 |
| Sanstec Limited | Administrative & support | 1999 |
| Santi's Solution Global Ltd | Health & social care | 2022 |
| SAP Seller Ltd | Wholesale & retail | 2025 |
| SAP SUB Limited | Hospitality | 2014 |
| Sapient Investments Ltd | Real estate | 2022 |
| Sapient Propco Limited | Real estate | 2025 |
| Sapphix Africa Ltd | Wholesale & retail | 2025 |
| Sara Robinson LP | | 2021 |
| Sara Robinson Trustees LP | | 2023 |
| Sarah Goddard Limited | Professional & scientific | 2007 |
| Sarah's Coffee Shop Limited | Hospitality | 2020 |
| Sarapovs Ltd | Construction | 2020 |
| Saresh Care Limited | Transport & logistics | 2016 |
| Sarfi's Ltd | Transport & logistics | 2020 |
| SAS Bespoke Ltd | Construction | 2018 |
| SAS Property Services Ltd | Construction | 2011 |
| SAS Tiling Limited | Construction | 2022 |
| Sasa Properties Limited | Administrative & support | 2011 |
| Sash Driving School Ltd | Education | 2025 |
| SAT Editing Services Limited | Information & communication | 2017 |
| Satsuma Creative Ltd | Professional & scientific | 2021 |
| Saturn Bird (UK) Ltd | Information & communication | 2025 |
| Satwal Limited | Administrative & support | 2015 |
| Sauntson & Baldry Properties Ltd | Real estate | 2019 |