| Sauntson Properties Ltd | Real estate | 2017 |
| SAV Metal Works Limited | Manufacturing | 2017 |
| Savannah Recruitment Ltd | Administrative & support | 2018 |
| Savannah Smoke Grill Ltd | Hospitality | 2026 |
| Save Accountancy Services Ltd | Administrative & support | 2017 |
| Saven West Ltd | Wholesale & retail | 2021 |
| Saverteck Ltd | Wholesale & retail | 2022 |
| Saving Care Ltd | Health & social care | 2023 |
| Savit Technologies Private Limited | Information & communication | 2023 |
| Savvy Software Ltd | Information & communication | 2023 |
| SAW Media Limited | Information & communication | 2019 |
| Saxmundham Service Centre Limited | Wholesale & retail | 2008 |
| Saxon Horizon Ltd | Hospitality | 2026 |
| Saxon Meadows (Capel ST Mary) Management Company Limited | Households | 2018 |
| SAY Investment Properties Ltd | Real estate | 2025 |
| SAY WOW Ltd | Arts & recreation | 2025 |
| SAZ Fortune Ltd | Wholesale & retail | 2026 |
| SB Group Holdings Limited | Hospitality | 2021 |
| SBB Hygiene Ltd | Health & social care | 2022 |
| SBG Essex Limited | Hospitality | 2019 |
| SBG Investment Holdings Limited | Real estate | 2025 |
| SBG North Ltd | Hospitality | 2020 |
| SBG Norwich Ltd | Hospitality | 2021 |
| SBG Riverside Limited | Hospitality | 2021 |
| SBG Suffolk Limited | Hospitality | 2018 |
| SBG Yorkshire Limited | Hospitality | 2021 |
| SBJ Totalservice Ltd | Manufacturing | 2026 |
| Sblm Suffolk Ltd | Health & social care | 2026 |
| SBM Concepts Ltd | Manufacturing | 2026 |
| SBS Ortho Group Ltd | Wholesale & retail | 2024 |
| SC Ipswich UK Limited | Hospitality | 2015 |
| SC Renewables Limited | Construction | 2015 |
| Scale LAB Ventures Limited | Professional & scientific | 2025 |
| Scales Music Ltd | Education | 2018 |
| Scalion Ltd | Wholesale & retail | 2026 |
| Scalpelskills Ltd | Health & social care | 2025 |
| Scanifly UK Ltd | Information & communication | 2021 |
| Scardia Properties Ltd | Real estate | 2026 |
| Scarlet Courier Services Ltd | Transport & logistics | 2023 |
| Scarz & Barz Ltd | Other services | 2023 |
| SCE Products Limited | Administrative & support | 2026 |
| Scentilove Limited | Wholesale & retail | 2025 |
| Sceptre Ventures Limited | Professional & scientific | 2015 |
| Schaefer Partners Limited | Financial services | 2016 |
| Schaffhausen Ltd | Real estate | 2020 |
| Schedvyn Request Flow Ltd | Information & communication | 2026 |
| Schmidox Technologies Limited | Wholesale & retail | 2025 |
| Scholar Space Ltd | Real estate | 2025 |
| Scholey Holdings Ltd | Financial services | 2018 |
| Schollar Consulting Limited | Administrative & support | 2020 |
| Schoollink Suffolk Ltd | Transport & logistics | 2025 |
| Schools IT Solutions Ltd | Information & communication | 2019 |
| Schumacher Cargo UK Ltd | Administrative & support | 2003 |
| Science Alan Ltd | Education | 2020 |
| Science Behind Sport Limited | Arts & recreation | 2024 |
| Science Makes Sense Ltd | Information & communication | 2021 |
| Scientech Prod Ltd | Information & communication | 2025 |
| Scimply Ltd | Hospitality | 2025 |
| Scintillance Ltd. | Information & communication | 2003 |
| Scirpus Properties Ltd | Real estate | 2019 |
| Sclin Ltd | Professional & scientific | 2008 |
| SCM Building Services Limited | Construction | 2016 |
| SCM Property Solutions Ltd | Households | 2023 |
| Scofield & Lait Roofing Limited | Construction | 2000 |
| Scope Aquatics Ltd | Wholesale & retail | 2024 |
| Scorpio Racing and Promotions Limited | Wholesale & retail | 1990 |
| Scott Forrest Boxing Ltd | Arts & recreation | 2022 |
| Scott GAS & Electrical Services Ltd | Construction | 2021 |
| Scott TM Ltd | Construction | 2024 |
| Scotty Miller Ltd | Arts & recreation | 2025 |
| Scouter Global Accountants Limited | Professional & scientific | 2023 |
| Screen Limited | Extraterritorial | 2009 |
| Screen Rescue Franchising Ltd. | Administrative & support | 2013 |
| Screen Rescue Ltd. | Wholesale & retail | 2013 |
| Scrutton Bland Limited | Professional & scientific | 2023 |
| SCS Consultants Limited | Information & communication | 2024 |
| SD Running Limited | Arts & recreation | 2021 |
| Sd&R Trading Limited | Construction | 2015 |
| SDC17 Limited | Health & social care | 2025 |
| Sdevi Pharma Limited | Wholesale & retail | 2015 |
| SDF Holdings Ltd | Wholesale & retail | 2018 |
| SDF Ventures Ltd | Wholesale & retail | 2026 |
| SDG Vision Community Interest Company | Manufacturing | 2020 |
| SDS Autoparts Ltd | Wholesale & retail | 2020 |
| SE7EN Wholesale Ltd | Wholesale & retail | 2024 |
| Sea Air Developments Ltd | Real estate | 2026 |
| Sea Light Medical Ltd | Administrative & support | 2019 |
| Sea Light Shine Ltd | Administrative & support | 2023 |
| Seabreeze Developments Limited | Real estate | 2019 |
| Seafield Barns Leverington Limited | Households | 2017 |
| Seager Heating Limited | Construction | 1997 |
| Seagull Engineering Limited | Construction | 2014 |
| Seal Plumbing & Heating Ltd | Construction | 2026 |
| Seale Print & Direct Mail Limited | Manufacturing | 2019 |
| Sealed Units Online Limited | Administrative & support | 2017 |
| Seamless Payroll Solutions Ltd | Professional & scientific | 2015 |
| Seamless Property Limited | Construction | 2018 |
| Seamus Oneill Transport Ltd | Transport & logistics | 2018 |
| Sean Hegarty Holding Company Limited | Professional & scientific | 2015 |
| Sean Hegarty Properties Limited | Real estate | 2012 |