| Sano Food Ltd | Hospitality | 2026 |
| Sansom's Railway Services Ltd. | Professional & scientific | 2017 |
| Sanus Vita Ltd | Wholesale & retail | 2019 |
| SBC Rail Limited | Manufacturing | 2006 |
| Sckb Ltd | Hospitality | 2025 |
| Scorpion Building Ltd | Construction | 2022 |
| Scott Peach Mechanical Engineering Services Limited | Professional & scientific | 2021 |
| Scriptinc Limited | Information & communication | 2012 |
| Scunas Ltd | Professional & scientific | 2023 |
| SDB Courier Ltd | Transport & logistics | 2025 |
| SDC Building Joinery & Groundworks Ltd | Construction | 2025 |
| Sea Lane Media Ltd | Transport & logistics | 2018 |
| Seam Seal International Ltd | Professional & scientific | 2014 |
| Seamers Kitchen Ltd | Hospitality | 2024 |
| Sean Paul Cleaning Ilkeston Limited | Administrative & support | 2021 |
| Seanzon Ltd | Real estate | 2025 |
| Seerey & Smith Building Solutions Limited | Construction | 2012 |
| Selectpackaging Limited | Wholesale & retail | 2013 |
| Sell IT Direct Limited | Wholesale & retail | 2017 |
| Senjen Electrical Ltd | Construction | 2021 |
| Sennailspa Limited | Other services | 2025 |
| Sensor Floor Ltd | Extraterritorial | 2012 |
| Sensory Technology Limited | Manufacturing | 1997 |
| SEO Property Ltd | Real estate | 2026 |
| Serendipity Training Group Ltd | Education | 2024 |
| Service Scale Marketing Ltd | Administrative & support | 2026 |
| Sesscon Fire Safety Solutions Limited | Administrative & support | 2024 |
| Setlen Limited | Real estate | 2024 |
| Seven Hills Contractors Ltd | Construction | 2018 |
| Seven Structures Limited | Professional & scientific | 2026 |
| Seventh Shard Limited | Information & communication | 2015 |
| Seyon Food & Wine Ltd | Wholesale & retail | 2025 |
| SGK OFF Licence Ltd | Wholesale & retail | 2022 |
| Shadeglass Games Ltd | Wholesale & retail | 2019 |
| Sharp Advice Limited | Administrative & support | 2015 |
| Shawside Construction Ltd | Construction | 2024 |
| Shazz & Co Freight Forwarding Limited | Transport & logistics | 2024 |
| Shed 2 Studios LLP | | 2011 |
| Shezalia Ltd | Professional & scientific | 2024 |
| Shiloh Cleaners Limited | Administrative & support | 2025 |
| Shipley Management Company Limited | Real estate | 2006 |
| Shocked Electrical Ltd | Construction | 2018 |
| Shocked Solar Energy Ltd | Construction | 2023 |
| Shot by TAZ Limited | Professional & scientific | 2024 |
| Shreya's Investment Ltd | Wholesale & retail | 2019 |
| SIA Property Group Ltd | Real estate | 2025 |
| Sign Forge Limited | Manufacturing | 2014 |
| Signs Direct Ltd | Manufacturing | 2002 |
| Signum Skin Clinic Ltd | Other services | 2025 |
| Silver Smiths of Nottingham Ltd | Manufacturing | 2024 |
| Simeonov Ltd | Transport & logistics | 2021 |
| SIS Construction U.K. Ltd | Extraterritorial | 2024 |
| SIS Digital Surveys UK Ltd | Extraterritorial | 2024 |
| SIS Group Europe Ltd | Extraterritorial | 2024 |
| SIS Group U.K. Ltd | Extraterritorial | 2024 |
| Sisson Plumbing & Heating Ltd | Construction | 2026 |
| Sizzlehub Ltd | Manufacturing | 2024 |
| SJ Coaching Ltd | Other services | 2023 |
| SJ Denman Projects Ltd | Professional & scientific | 2022 |
| SJ Gilhooly Ltd | Construction | 2017 |
| SJ Jhakhas Spice Ltd | Hospitality | 2018 |
| SJP Property Lettings Ltd | Real estate | 2025 |
| SJP Renewables Ltd | Professional & scientific | 2026 |
| SJW Accountancy Limited | Professional & scientific | 2025 |
| SKS Property Rental Ltd | Real estate | 2019 |
| Skyblade Limited | Manufacturing | 2013 |
| Skyeworx Limited | Manufacturing | 2014 |
| SL Clean Ltd | Administrative & support | 2025 |
| SL Developers Ltd | Real estate | 2020 |
| SL Developments & Property Management Ltd | Real estate | 2018 |
| Slater Civils Ltd | Construction | 2020 |
| Sliding Door Wardrobes Ltd | Manufacturing | 2002 |
| Slightly Potty Ltd | Arts & recreation | 2019 |
| Slik Screeners Limited | Manufacturing | 1963 |
| Smalley Convenience Ltd | Wholesale & retail | 2023 |
| Smallwood Builders & Renovations Ltd | Construction | 2026 |
| Smart Kraken Ltd. | Hospitality | 2016 |
| Smart Tyres Centre Limited | Wholesale & retail | 2024 |
| SMC (Notts) Ltd | Construction | 2021 |
| SMC Automotive Services Limited | Wholesale & retail | 2012 |
| SMD Management (Ilkeston) Ltd | Construction | 2026 |
| Smeets Engineering Limited | Manufacturing | 2005 |
| Soar Digital Ltd | Information & communication | 2020 |
| Soaring Developments Ltd | Construction | 2024 |
| Social Therapy Ltd | Health & social care | 2026 |
| Sofa 24 Ltd | Wholesale & retail | 2019 |
| Solutionspad Ltd | Information & communication | 2021 |
| Sorill Property Limited | Real estate | 2019 |
| Source Studios Ltd | Information & communication | 2026 |
| South Notts (Builders) Ltd | Construction | 2009 |
| South Perk Sandwich Bar Ltd | Hospitality | 2015 |
| Sparkley Kleen Limited | Administrative & support | 2017 |
| Sparky Electrical Services Ltd | Construction | 2019 |
| SPARTA69 Ltd | Transport & logistics | 2019 |
| Special Purpose Electrical Contractors Limited | Professional & scientific | 2017 |
| Specialist Weee Services (SWS) Limited | Water & waste | 2021 |
| Spectrum Derbyshire CIC | Health & social care | 2019 |
| Spencer Care and Staffing Limited | Administrative & support | 2021 |
| Spike Consulting Limited | Information & communication | 2007 |
| Spinney Joinery and Building Ltd | Construction | 2025 |