| SPK Grounds Services Limited | Administrative & support | 2022 |
| Spoiltland NW Ltd | Wholesale & retail | 2024 |
| Sporting Evenings Ltd | Professional & scientific | 2020 |
| Sportoffer Limited | Hospitality | 1994 |
| Sprayworld East Midlands Ltd | Construction | 2026 |
| Spring Cottage Ilkeston Ltd | Hospitality | 2023 |
| Springtime Housing Association | Hospitality | 1997 |
| Springvale Leisure Limited | Manufacturing | 2002 |
| SPROP23 Ltd | Households | 2023 |
| SR Construct Ltd | Construction | 2026 |
| SS & SB Limited | Hospitality | 2006 |
| ST. Johns Packaging (UK) Limited | Manufacturing | 2020 |
| Stage Connections Ltd | Administrative & support | 2011 |
| Standshill Support Limited | Health & social care | 2025 |
| Stanton Barbers Limited | Other services | 2019 |
| Stanton Park Limited | Health & social care | 2025 |
| Stanton Property Group Ltd | Real estate | 2026 |
| Starline Bathrooms Ltd | Construction | 2024 |
| Station Mortgages Limited | Professional & scientific | 2022 |
| Status Metrology Solutions Ltd | Manufacturing | 1993 |
| STE Keeton Roofing Limited | Construction | 2024 |
| Stephen Harvey Limited | Construction | 2003 |
| Sterling Supported Living Limited | Health & social care | 2023 |
| Stirland Paterson (Holdings) Limited | Financial services | 2001 |
| Stirland Paterson (Printers) Ltd | Manufacturing | 1996 |
| Stirland Paterson Group Limited | Financial services | 2026 |
| Stolen Car Trackers Ltd | Wholesale & retail | 2024 |
| Stonegate Logistics Ltd | Transport & logistics | 2023 |
| Stork Corporation Ltd | Other services | 2025 |
| Stratford Construction Limited | Construction | 1999 |
| Stratford Property Company Limited | Real estate | 2007 |
| Streamline Bespoke Design Build Limited | Construction | 2025 |
| Streetwisesubbie.Com Limited | Professional & scientific | 2008 |
| Strong Tower Social Care Services Ltd | Public administration | 2024 |
| Structrd Ltd | Wholesale & retail | 2025 |
| Structural Investigation Services Limited | Construction | 2018 |
| Structural Steel Consultants (SSC) Ltd | Administrative & support | 2016 |
| Studio Arko Limited | Professional & scientific | 2025 |
| Studio Sielle Ltd | Information & communication | 2024 |
| Style Cutz Ilkeston Ltd | Other services | 2025 |
| SUE Freeman Photography Ltd | Professional & scientific | 2020 |
| Sukhi Estates Ltd | Real estate | 2024 |
| Sumpton (Ilkeston) Ltd | Health & social care | 2007 |
| Super 88 Ltd | Financial services | 2025 |
| Super Fish Bar and OFF Licence Ltd | Wholesale & retail | 2021 |
| Supplement City Ltd | Wholesale & retail | 2022 |
| Sure Futures Development Ltd | Real estate | 2018 |
| Sure Futures Residential Ltd | Real estate | 2018 |
| Surface Revive Ltd | Administrative & support | 2025 |
| Surge Roofing Contractors Ltd | Real estate | 2026 |
| Survivors of Bereavement by Suicide | Other services | 2003 |
| SW Construct Ltd | Construction | 2024 |
| SWB Commercial and Project Management Limited | Construction | 2017 |
| Sweet Scents by Krystal Ltd | Wholesale & retail | 2026 |
| SWJ Solutions Ltd | Construction | 2013 |
| Symanhire (East Midlands) Limited | Hospitality | 1977 |
| Synergy R.S.C. Limited | Construction | 2011 |
| Syriusz Black Limited | Professional & scientific | 2026 |
| T a W Recycling Limited | Water & waste | 2016 |
| T G Transports Motors Ltd | Transport & logistics | 2024 |
| T K Construction (Nottingham) Limited | Real estate | 2004 |
| T L Catering Limited | Hospitality | 2007 |
| T Sisson Properties Ltd | Real estate | 2016 |
| T&M Grab Hire Services Ltd | Water & waste | 2021 |
| T&M Groundworks and Surfacing Ltd | Administrative & support | 2025 |
| T.I.M. UK Motors Ltd | Wholesale & retail | 2012 |
| T.P. Hopwell (Birmingham) Limited | Wholesale & retail | 1982 |
| T.P. Hopwell (Holdings) Limited | Other services | 1976 |
| T.W. Engineering Company Limited | Manufacturing | 1960 |
| T.W. Engineering Holdings Limited | Manufacturing | 2021 |
| T.W. Tools Limited | Professional & scientific | 1996 |
| T4 Sustainability Limited | Manufacturing | 2002 |
| TA Moko Fightwear Limited | Arts & recreation | 2022 |
| Taag at Home Bookkeeping Services Ltd | Professional & scientific | 2023 |
| Taam OSF Holdings Limited | Professional & scientific | 2024 |
| Tabletop Fabrications Ltd | Wholesale & retail | 2025 |
| Tabor Trans Ltd | Transport & logistics | 2025 |
| TAG Star Catering Ltd | Hospitality | 2022 |
| TAG Star Retail Ltd | Wholesale & retail | 2022 |
| TAI HUA Takeaway Limited | Hospitality | 2025 |
| Talk Green Limited | Professional & scientific | 2012 |
| Tariyaa Group Ltd | Information & communication | 2020 |
| Tathams Personal Training Ltd | Wholesale & retail | 2022 |
| Tats & Packs Ltd | Wholesale & retail | 2026 |
| TATS2STITCHES Ltd | Manufacturing | 2025 |
| Tavin Group Ltd | Wholesale & retail | 2024 |
| Tax Applications Ltd | Information & communication | 2025 |
| Taxi-Man Ltd | Transport & logistics | 2015 |
| Taylor Building Services (Midlands) Limited | Construction | 2017 |
| TBF (Suffolk) Ltd | Real estate | 2020 |
| TBS Compliance Limited | Professional & scientific | 2022 |
| Teal Horizon Homes Limited | Real estate | 2025 |
| Teambus Ltd | Transport & logistics | 2020 |
| Techcon Limited | Construction | 2014 |
| Techmaintain Limited | Manufacturing | 2016 |
| Technifab Engineering (Midlands) Ltd | Manufacturing | 2011 |
| Technocycle Solutions Ltd | Wholesale & retail | 2020 |
| Techrevive (Midlands) Ltd | Wholesale & retail | 2026 |
| Telluric Remediation Management Limited | Water & waste | 2003 |
| Templur Luxe Mattress Pillows & Beds Ltd | Manufacturing | 2019 |