| DP Pension Holdings Co Ltd | Real estate | 2020 |
| DPA Lighting Limited | Wholesale & retail | 2004 |
| DPG Contracts Limited | Administrative & support | 2021 |
| DR Olivia Consultancy Services Ltd | Education | 2025 |
| Draconet Ltd | Information & communication | 2014 |
| Draper (Developments) Limited | Manufacturing | 2000 |
| Dream Homes Manchester Ltd | Real estate | 2025 |
| Dream INK Ltd | Arts & recreation | 2025 |
| Dream Sky Tech UK Limited | Information & communication | 2023 |
| Dreams Mini Market Ltd | Wholesale & retail | 2025 |
| Drivepol Limited | Transport & logistics | 2013 |
| Drytech Roofing Solutions Limited | Construction | 2016 |
| DS Windows Doors & Conservatories Limited | Construction | 2016 |
| DSJ Estates Ltd | Real estate | 2021 |
| Dualpoint Transport Ltd | Transport & logistics | 2026 |
| Duffy Civil Engineering Limited | Construction | 2004 |
| Dukinfield Auto Centre Ltd | Wholesale & retail | 2025 |
| Dukinfield Iron Works Limited | Real estate | 2018 |
| Dupseund Limited | Health & social care | 2023 |
| Dutteedetailer Ltd | Wholesale & retail | 2026 |
| DWH TM Ltd | Construction | 2024 |
| DXL & Co. Ltd | Administrative & support | 2026 |
| Dycomet UK Limited | Wholesale & retail | 2014 |
| Dynasty Chinese Takeaway (Hyde) Ltd | Hospitality | 2023 |
| E&E Cooney Limited | Hospitality | 2025 |
| E-Spark Electrical Ltd | Construction | 2016 |
| E.J.H.Nanny Limited | Health & social care | 2023 |
| E.J.Lighting Ltd | Information & communication | 2021 |
| E.K.E Tech Ltd | Information & communication | 2021 |
| Eakmedia Limited | Wholesale & retail | 2010 |
| EAR Doctors Microsuction Clinic UK Limited | Health & social care | 2020 |
| East Ghandiyal Ltd | Hospitality | 2026 |
| East Manchester Historical Games Limited | Real estate | 2007 |
| Eastern Bluebird Couriers Limited | Administrative & support | 1990 |
| Ebsd Limited | Professional & scientific | 1985 |
| Ebuwei & Sons Limited | Health & social care | 2018 |
| Eco Climate Solutions Ltd | Construction | 2021 |
| Ecommerce Mining Ltd | Wholesale & retail | 2023 |
| ECT Consulting Limited | Financial services | 2024 |
| ECT Crematoria Servicing Limited | Manufacturing | 2025 |
| Eden First Limited | Professional & scientific | 2011 |
| Eden Shisha Ltd | Hospitality | 2020 |
| Edgeworth Taverns Limited | Hospitality | 2009 |
| EJA Developments Limited | Construction | 2025 |
| EJA Estates Limited | Real estate | 2016 |
| Electel Systems Design Limited | Professional & scientific | 2020 |
| Electrical Automation Solutions Limited | Manufacturing | 2013 |
| Elevation 13 Limited | Arts & recreation | 2026 |
| Elevation Property Holdings Ltd | Financial services | 2026 |
| Eleven Eleven Developments Ltd | Real estate | 2025 |
| Elite Five Pizza Ltd | Wholesale & retail | 2024 |
| Elite Pipework Solutions Ltd | Manufacturing | 2023 |
| Elite Properties Bolton Limited | Construction | 2021 |
| Elizabeth Rose Properties Limited | Real estate | 2019 |
| Elle James Makeup Limited | Wholesale & retail | 2023 |
| Ellisa Developments Limited | Construction | 2025 |
| ELM Lettings Ltd | Real estate | 2025 |
| Elsa Accountancy Ltd | Professional & scientific | 2025 |
| Elsa Bridging Ltd | Real estate | 2024 |
| Elvira Inspiring Success Ltd | Education | 2024 |
| Elysium Estates Group Limited | Real estate | 2023 |
| Emafadiv Limited | Other services | 2016 |
| Emcas Joinery and Construction Limited | Construction | 2021 |
| Emerald Distillery Ltd | Extraterritorial | 2024 |
| Emerald GIN Limited | Manufacturing | 2019 |
| Emma Shepley Services Limited | Health & social care | 2025 |
| Empire Property Assets Limited | Real estate | 2023 |
| Empower Music Productions Ltd | Wholesale & retail | 2024 |
| EMR Joinery Ltd | Manufacturing | 2026 |
| EMY Hire Limited | Administrative & support | 2023 |
| Enchanted Productions Ltd | Arts & recreation | 2025 |
| Enforcement Solutions Group Limited | Administrative & support | 2023 |
| Enigma Food Safety Ltd | Professional & scientific | 2024 |
| Enkido Security Limited | Administrative & support | 2023 |
| Enterprise Education (Bolton) Ltd | Education | 2014 |
| Entertainment Storage Limited | Transport & logistics | 2023 |
| Environmental Combustion Technologies (Holdings) Limited | Financial services | 2024 |
| Environmental Combustion Technologies Limited | Manufacturing | 2011 |
| Equity Shopfitting and Construction Limited | Construction | 1991 |
| ERJ Automotive Limited | Wholesale & retail | 2026 |
| ESA Holdings Ltd | Construction | 2017 |
| Escaline Ltd | Construction | 2025 |
| ESD Fitness Group UK Limited | Information & communication | 2026 |
| Esfdt Ltd | Manufacturing | 2021 |
| Esha Hyde Ltd | Hospitality | 2025 |
| Esprit Facilities Management Limited | Transport & logistics | 2011 |
| Esprit Trading Group Limited | Financial services | 2015 |
| Esprit Warehousing Limited | Transport & logistics | 2015 |
| Esteme Ltd | Wholesale & retail | 2013 |
| Eswitch UK (NW) Ltd | Administrative & support | 2016 |
| ETA Media Ltd | Information & communication | 2016 |
| Etherow Developments Ltd | Construction | 2025 |
| Etherow Ltd | Information & communication | 2024 |
| Euhomy Fusions Limited | Manufacturing | 2024 |
| Euro Bangla Association Greater Manchester Ltd | Other services | 2023 |
| Euro Shop Hyde Ltd | Wholesale & retail | 2026 |
| Eurosia Party Banquet Ltd | Hospitality | 2024 |
| Evaryn Limited | Wholesale & retail | 2026 |
| Event Storage Ltd | Transport & logistics | 2019 |
| Event Transport Holdings Ltd | Financial services | 2023 |