| D & L Property Contractors Limited | Construction | 2020 |
| D Bowden Transport Limited | Transport & logistics | 2024 |
| D J M C Engineering Limited | Administrative & support | 2006 |
| D R Property Solutions (NW) Limited | Construction | 2024 |
| D&Dcooper Ltd | Hospitality | 2025 |
| D.F. Walker (Pharmacy) Limited | Wholesale & retail | 1990 |
| D.I.S.C. Groundwork & Construction Limited | Construction | 2011 |
| Daisy Chain Beautique Ltd | Other services | 2023 |
| Daisy Construction and Groundworks Ltd | Construction | 2024 |
| Daisy Hill Properties Ltd | Real estate | 2020 |
| Daleen Bridal Ltd. | Wholesale & retail | 2019 |
| Dameer Traders Ltd | Wholesale & retail | 2023 |
| Dandylion Entertainment Ltd | Professional & scientific | 2021 |
| Dane Bank Kids Club Limited | Health & social care | 2010 |
| Daniel Barczak Limited | Information & communication | 2018 |
| Daniel Husband Painting & Decorating Ltd | Construction | 2019 |
| Danilux Ltd | Wholesale & retail | 2014 |
| Dannlads Limited | Construction | 2025 |
| Daremil Ltd | Wholesale & retail | 2024 |
| Daresbury Cat House Limited | Other services | 2017 |
| Dark Peak Barbers Limited | Other services | 2019 |
| Darlie Estates Ltd | Real estate | 2025 |
| Dartssuppliesshop Ltd | Arts & recreation | 2011 |
| Dasco Construction Ltd. | Construction | 2014 |
| Dasco Group Limited | Financial services | 2020 |
| Data Defence Group Ltd | Information & communication | 2010 |
| Data Defence Limited | Information & communication | 2009 |
| Data Solutions North West Ltd | Construction | 2024 |
| Datum Construction Ltd | Construction | 2024 |
| Davenport & Flinn Limited | Professional & scientific | 2004 |
| Davic Empire Limited | Extraterritorial | 2025 |
| David Maccreedy Productions Ltd | Arts & recreation | 2026 |
| David P. Winterbottom (Haulage) Limited | Transport & logistics | 1986 |
| DB Exhibition Services Ltd | Construction | 2019 |
| DB Gardens Grow and Flourish Community Interest Company | Agriculture & fishing | 2019 |
| DCI Electrical Contractors Limited | Construction | 2012 |
| DCI Events Ltd | Professional & scientific | 2025 |
| DCM Property Group Ltd | Real estate | 2026 |
| DDH Motor Imports Limited | Wholesale & retail | 2025 |
| Dealmakers Club Ltd | Education | 2025 |
| Dean Food Limited | Professional & scientific | 2023 |
| Debrock Consulting Limited | Professional & scientific | 2023 |
| Debt Concerns Limited | Other services | 2015 |
| Decorated (UK) Limited | Construction | 2024 |
| Decorating 4U Ltd | Construction | 2026 |
| DEE Guru Ltd | Wholesale & retail | 2018 |
| Deemwae Ltd | Wholesale & retail | 2021 |
| Deep Water Holdings Ltd | Financial services | 2021 |
| Delhi Spice NW Ltd | Hospitality | 2024 |
| Delhi Spice Tameside Ltd | Hospitality | 2026 |
| Delivered Logistics Limited | Transport & logistics | 2019 |
| Deliveryforyou Limited | Transport & logistics | 2025 |
| Delux Travels Airport Transfers Ltd | Transport & logistics | 2025 |
| Deluxe Danish Bakes Ltd | Wholesale & retail | 2025 |
| Dent Elite Ltd | Wholesale & retail | 2015 |
| Denton Roofing Limited | Construction | 2013 |
| Deprivation.Org | Professional & scientific | 2014 |
| Derbyshire Padel Ltd | Arts & recreation | 2025 |
| Derek Anthony Holdings Limited | Manufacturing | 2007 |
| Derek Anthony Limited | Manufacturing | 1989 |
| Desc Holdings Ltd | Administrative & support | 2020 |
| Determinant Labs Ltd | Professional & scientific | 2026 |
| Developed With Style Limited | Information & communication | 2016 |
| Dgtlk Investments Ltd | Real estate | 2022 |
| DH Construction NW Ltd | Construction | 2022 |
| DHT Finance Limited | Financial services | 2015 |
| Diamond Export Industries Ltd | Wholesale & retail | 2024 |
| Diamonds of Cheshire Ltd | Wholesale & retail | 2021 |
| Diefold UK Limited | Manufacturing | 2011 |
| Dietan Construction Ltd | Construction | 2023 |
| Digital Manchester Limited | Professional & scientific | 2021 |
| Direct Care (Tameside) Ltd | Health & social care | 2011 |
| Direct Exchange Limited | Other services | 2016 |
| Diverse Damp Proofing Ltd | Other services | 2025 |
| Diverse Hospitality Ltd | Hospitality | 2021 |
| DIY Weddings Limited | Other services | 2016 |
| Diya Catering and Event Ltd | Hospitality | 2017 |
| Dj's Patios and Paths Limited | Construction | 2024 |
| DK Chem Organic Synthesis Ltd | Manufacturing | 2012 |
| DM Decor North West Ltd | Construction | 2024 |
| DM Floors Ltd | Other services | 2025 |
| Dmc.Twentytwo Ltd | Health & social care | 2015 |
| DNA Developments Hyde Limited | Construction | 2010 |
| DNA Developments Limited | Construction | 2002 |
| DNA VAG Parts Limited | Wholesale & retail | 2024 |
| Dncw Ltd | Hospitality | 2024 |
| DNK Housing Ltd | Real estate | 2026 |
| DNO Barber PVT Ltd | Other services | 2024 |
| Dogs and FUN Limited | Other services | 2020 |
| Doneview Limited | Real estate | 2002 |
| Dorr Dental Suppliers Limited | Manufacturing | 2025 |
| Double D'S (Cafe) Ltd | Other services | 2025 |
| Double D'S Trading Ltd | Wholesale & retail | 2018 |
| Double D’S 2020 Ltd | Other services | 2024 |
| Doufange Limited | Health & social care | 2012 |
| Douglas Medical and Healthcare Limited | Health & social care | 2025 |
| Dowo Cloud Limited | Information & communication | 2025 |
| Dowo Digital Limited | Information & communication | 2015 |
| Dowo Group Limited | Administrative & support | 2024 |
| DP Pension Contractors Limited | Construction | 2026 |