| Simply Venetian Ltd | Construction | 2025 |
| Sineco Ltd | Information & communication | 2025 |
| Singleton Property Group Limited | Real estate | 2022 |
| Sirikan Limited | Professional & scientific | 2013 |
| Siseri Couriers Ltd | Transport & logistics | 2026 |
| SIX Step CFS Ltd | Information & communication | 2022 |
| SJ Design's (UK) Limited | Administrative & support | 2008 |
| SJ Holdings & Investments Limited | Real estate | 2016 |
| SJH (Marl Hall) Limited | Real estate | 2025 |
| SK Tradehub Limited | Wholesale & retail | 2025 |
| SK14OFFSHORE Limited | Construction | 2025 |
| Skilful Conversation Limited | Administrative & support | 2018 |
| Skill 2 Ltd | Wholesale & retail | 2026 |
| SKILL2 Enterprises Limited | Wholesale & retail | 2023 |
| SKILL3 Enterprises House Limited | Real estate | 2023 |
| Skillhaus Decorating Services Limited | Construction | 2013 |
| Skills Recognition Limited | Education | 2014 |
| Skillsstream Ltd | Education | 2025 |
| Skinclinic.Mcr Ltd | Other services | 2020 |
| Skylar Investments Limited | Real estate | 2024 |
| Skylarshairandbeautysalon Limited | Other services | 2018 |
| SLB Property Group Limited | Real estate | 2023 |
| SLH Home Design Ltd | Professional & scientific | 2020 |
| Slik Holdings Limited | Manufacturing | 2006 |
| Slik Plus Ltd | Manufacturing | 2024 |
| Slik-Pak Holdings Limited | Manufacturing | 2019 |
| Slik-Pak Limited | Wholesale & retail | 1992 |
| SLK Education Ltd | Education | 2022 |
| SM Direct (Property) Limited | Real estate | 2018 |
| SM Direct (Retail) Limited | Wholesale & retail | 2014 |
| Smart Installations (Cheshire) Limited | Construction | 2017 |
| Smash'D Hyde Ltd | Hospitality | 2026 |
| Smash'D Ltd | Hospitality | 2024 |
| Smatt Care Ltd | Health & social care | 2023 |
| Smith Brothers Holdings Limited | Professional & scientific | 1990 |
| SMMS2 Ltd | Information & communication | 2023 |
| Snacktap Vending Limited | Wholesale & retail | 2024 |
| Snow White Aesthetics Academy Ltd | Other services | 2019 |
| Snow White Veneers Limited | Other services | 2018 |
| Snug Windows Ltd | Construction | 2024 |
| SO Sweet Manchester Ltd | Wholesale & retail | 2024 |
| Soap Installations Limited | Construction | 2015 |
| Softology Holdings Limited | Information & communication | 2011 |
| Softology Limited | Information & communication | 1991 |
| Solid Ground Driveways Ltd | Construction | 2026 |
| Solution Environmental Services Limited | Construction | 2013 |
| Somerville Management Company Limited | Real estate | 2015 |
| Sona Utilities Limited | Construction | 2025 |
| SONO-11 Diagnostics Ltd | Health & social care | 2025 |
| Sorchask Ltd | Real estate | 2023 |
| Sorption Wheel Services Limited | Manufacturing | 1996 |
| SP Cricket Ltd | Arts & recreation | 2022 |
| Sparklex Ltd | Administrative & support | 2024 |
| Sparky Training Ltd | Education | 2024 |
| Spartcon Limited | Construction | 2025 |
| Speakeasy Barber Club Ltd | Other services | 2023 |
| Specialist Cleaning Services UK Limited | Administrative & support | 2003 |
| Spectrum Vehicle Contracts Ltd | Wholesale & retail | 2013 |
| Speech Banana Ltd | Public administration | 2021 |
| Speedweld Ltd | Professional & scientific | 2022 |
| Speedy Electrical Solutions Ltd | Construction | 2024 |
| Spencer Hayes Group Limited | Financial services | 2013 |
| Spencer Hayes Protect Ltd | Financial services | 2026 |
| Spilsbury Consulting Limited | Extraterritorial | 2004 |
| SPJ Wealth Management Ltd | Administrative & support | 2016 |
| Sports Solutions Limited | Arts & recreation | 2020 |
| Spotbee Limited | Wholesale & retail | 2025 |
| Sppiromart Ltd | Wholesale & retail | 2024 |
| Sprc Properties Ltd | Real estate | 2017 |
| Spriggs Photography Limited | Professional & scientific | 2013 |
| Spring Top Rise Ltd | Households | 2024 |
| Springmoor Developments Ltd | Real estate | 2000 |
| Sprout & Settle Ltd | Real estate | 2025 |
| SPS Projects Limited | Other services | 2018 |
| SPW Installations Limited | Construction | 2017 |
| SR Transfers and Barbers Cafe Ltd | Financial services | 2024 |
| Srmg Limited | Wholesale & retail | 2023 |
| SRR Pictures Ltd | Information & communication | 2022 |
| SS Mining Store Ltd | Wholesale & retail | 2024 |
| SS Visual Ltd | Information & communication | 2021 |
| Stable Court Holdings Limited | Financial services | 2016 |
| Stage Unlocked Ltd | Arts & recreation | 2026 |
| Stan Scaffolding Services Ltd | Construction | 2025 |
| Standardway Limited | Real estate | 1986 |
| Stanley Ogden Limited | Wholesale & retail | 2004 |
| Star Coaching and Consultancy Ltd | Professional & scientific | 2019 |
| Starchaser Industries Limited | Transport & logistics | 1998 |
| Starlight Rose C.I.C. | Health & social care | 2026 |
| Starlite Daycare Ltd | Health & social care | 2024 |
| Steeles 1960 Limited | Extraterritorial | 2013 |
| Steline Shopfitting Limited | Construction | 2004 |
| Stem Injection Systems (Europe) Ltd | Construction | 2007 |
| Stephen Carter Rail Limited | Construction | 2024 |
| Stephen Ellis Construction Cost Consultancy Ltd. | Professional & scientific | 1998 |
| Stephen Webb PT Ltd | Other services | 2025 |
| Sterling Finishes Ltd | Construction | 2012 |
| STH Commercial Upholstery Limited | Other services | 2023 |
| Stinky PIG Limited | Manufacturing | 2021 |
| Stockbridge Airco Fans Service and Spares Limited | Other services | 1983 |
| Stockwell Homes Limited | Real estate | 2020 |