| S & S (2019) Limited | Other services | 2019 |
| S Birdsey Properties Limited | Real estate | 2025 |
| S&G Constraction Ltd | Administrative & support | 2025 |
| S&J Promotions Ltd | Hospitality | 2024 |
| S.A.M.A. Accountants Ltd | Financial services | 2021 |
| S.K. Medical (London) Limited | Health & social care | 2013 |
| S3 Design and Development Limited | Professional & scientific | 2014 |
| Saddleworth Law Limited | Professional & scientific | 2021 |
| Safeguard Fire and Compliance Ltd | Construction | 2025 |
| Safety First Social Care Ltd | Public administration | 2026 |
| Safety Zone (Europe) Limited | Administrative & support | 1997 |
| Safrasia Ltd | Hospitality | 2020 |
| Sage Property Group Ltd | Real estate | 2021 |
| Saies & Campbell Ltd | Real estate | 2023 |
| Saiohken Limited | Wholesale & retail | 2025 |
| Saivora Ltd | Wholesale & retail | 2026 |
| Salt Creative Marketing Limited | Administrative & support | 2022 |
| Sal’S Flavours Ltd | Hospitality | 2026 |
| SAM Events Ltd | Arts & recreation | 2024 |
| SAM N a Scran Limited | Other services | 2025 |
| Sameeksha UK Ltd | Administrative & support | 2020 |
| Samerin Commercial Limited | Real estate | 2021 |
| Samerin Properties Limited | Real estate | 2015 |
| Samson Estates Ltd | Real estate | 2025 |
| SAN Judas Tadeo Limited | Wholesale & retail | 2024 |
| Sanctum of Maps Ltd | Arts & recreation | 2026 |
| Sandowl Ltd | Arts & recreation | 2017 |
| Sanesca Limited | Wholesale & retail | 2023 |
| Santon Group Limited | Construction | 2015 |
| Santon Lightning Protection Services Limited | Construction | 2003 |
| Sapphire Catering Supplies Ltd | Hospitality | 2020 |
| Sapphire Catering Supplies Manchester Ltd | Hospitality | 2025 |
| Sarmec Services Ltd | Professional & scientific | 2015 |
| SAS Engineering & Projects Ltd | Construction | 2025 |
| SAS Northwest Ltd | Financial services | 2026 |
| Saunders Properties (North West) Limited | Real estate | 2021 |
| Sauz Group Ltd | Wholesale & retail | 2023 |
| SB Campervan Rentals Ltd | Administrative & support | 2021 |
| SBH Platform 1 Ltd | Hospitality | 2025 |
| Scaffolding 365 Limited | Construction | 2014 |
| Scan Van Group Limited | Public administration | 2026 |
| Scan Van London Ltd | Other services | 2026 |
| Scar Property Consultants Limited | Construction | 2016 |
| Scented Highs Ltd | Wholesale & retail | 2025 |
| SCH2 & Associates Limited | Professional & scientific | 2023 |
| Scott's Mobile Caravan Servicing Limited | Manufacturing | 2019 |
| SCOTTRAIL11 Limited | Construction | 2019 |
| Scribble Hairdressing Limited | Other services | 2010 |
| SD Multi Trade Ltd | Construction | 2022 |
| Sdhi Ltd | Construction | 2019 |
| Seamless Transitions Consulting Ltd | Professional & scientific | 2017 |
| Secure Gaming Limited | Administrative & support | 2012 |
| Seddon Surveys Limited | Construction | 2021 |
| Selander Group Limited | Information & communication | 2024 |
| Selnec Media Ltd | Information & communication | 2024 |
| Seneca US OIL & GAS Opportunities Fund | | 2009 |
| Senior View Property Management Limited | Households | 1990 |
| Seven Rail Engineering Ltd | Professional & scientific | 2007 |
| Seymour Sign & Print Ltd | Professional & scientific | 2013 |
| Sezi & Co Ltd | Administrative & support | 2021 |
| Sfimona Limited | Administrative & support | 2022 |
| SGB Asset Management Limited | Wholesale & retail | 2016 |
| SGB Securities Ltd | Construction | 2019 |
| SH Group U.K. Ltd | Construction | 2020 |
| SH Properties (NW) Ltd | Real estate | 2026 |
| Shahera Limited | Wholesale & retail | 2024 |
| Shahriars Logistics Ltd | Transport & logistics | 2025 |
| Shaikh's and Sons Ltd | Wholesale & retail | 2025 |
| Shakes and Bakes (Tameside) Limited | Hospitality | 2022 |
| Shandies at the Railway Ltd | Hospitality | 2026 |
| Sharmin Begum Ltd | Public administration | 2016 |
| Shawarma House Hyde Limited | Hospitality | 2021 |
| Shawston Metal Products Limited | | 1965 |
| SHE of Romiley Ltd | Wholesale & retail | 2017 |
| Shehzad Sons Limited | Wholesale & retail | 2021 |
| Shepherds Drinks Ltd | Administrative & support | 2018 |
| Shepley Aluminium Systems Limited | Manufacturing | 2022 |
| Shepley Land & Security Limited | Households | 2022 |
| Shine on Hyde Ltd | Wholesale & retail | 2025 |
| Shine on Manchester Ltd | Wholesale & retail | 2022 |
| Shining Stars Day Nursery (Hyde) Ltd | Health & social care | 2024 |
| Shinybee Cleaning Limited | Administrative & support | 2025 |
| Shirley Spinning & NON Wovens Limited | Manufacturing | 2017 |
| Shirley Ventures Ltd | Health & social care | 2015 |
| Shiva SAI Properties Ltd | Real estate | 2025 |
| Shoab Uddin Education Consultancy Limited | Education | 2024 |
| Shop Monk Ltd | Other services | 2013 |
| Showzazpharm Limited | Other services | 2020 |
| Sign UP to Save Ltd | Information & communication | 2021 |
| Silver Point Padel Ltd | Arts & recreation | 2026 |
| Silver Wolf Homes Limited | Real estate | 2022 |
| Silverdale Investment Properties Ltd | Real estate | 2025 |
| Silverhill Accounting Services Ltd | Professional & scientific | 2019 |
| Silwen Limited | Financial services | 2002 |
| Simahech Limited | Real estate | 2018 |
| Simant Ltd | Professional & scientific | 2024 |
| Simonda Edge IT Limited | Information & communication | 2012 |
| Simply Chinese 168 Ltd | Hospitality | 2024 |
| Simply Scrubs Limited | Wholesale & retail | 2024 |
| Simply Sunshine Aesthetics Ltd | Health & social care | 2023 |