| Smartperiai Ltd | Hospitality | 2026 |
| Smartshaw Limited | Agriculture & fishing | 2018 |
| Smashing Pinos Ltd | Wholesale & retail | 2024 |
| SMC Foods Ltd | Manufacturing | 2026 |
| Smeathalls Farm Energy Limited | Professional & scientific | 2019 |
| SMH 59 Ltd | Health & social care | 2025 |
| Smile@ Ltd | Health & social care | 2011 |
| Smiley Badger's Ltd | Manufacturing | 2025 |
| Smith & Jennings Ltd | Manufacturing | 2013 |
| Smith & SON Developments (Yorkshire) Limited | Construction | 2026 |
| Smith Agri-Tech Ltd | Manufacturing | 2024 |
| Smith Allen Ltd | Professional & scientific | 2020 |
| Smith Medical Group Limited | Health & social care | 2015 |
| Smith Power Services Ltd | Administrative & support | 2017 |
| Smitha Properties Limited | Real estate | 2025 |
| Smiths Container Storage Ltd | Real estate | 2012 |
| Smiths Court Management Limited | Households | 2000 |
| Smiths Opticians Ltd | Health & social care | 2010 |
| Smiths Properties Yorkshire Ltd | Real estate | 2022 |
| Smiths Transport Services 2024 Limited | Transport & logistics | 2024 |
| Smithson and Littlewood Interiors by Design Limited | Construction | 2022 |
| Smjd Health Limited | Health & social care | 2021 |
| SMK Accounting Solutions Ltd | Professional & scientific | 2023 |
| Smmbirds Ltd | Professional & scientific | 2025 |
| Smoke&Vape UK Ltd | Wholesale & retail | 2022 |
| Smoknic Ltd | Wholesale & retail | 2014 |
| Smosh Group Ltd | Wholesale & retail | 2016 |
| SMR Demolition Services Ltd | Construction | 2018 |
| Smra Property Holdings Ltd | Real estate | 2021 |
| SMS Properties (Huddersfield) Limited | Real estate | 2018 |
| SMW Electrical Services Ltd | Construction | 2024 |
| SMZ HD Ltd | Wholesale & retail | 2024 |
| SN Legal Consultants Limited | Professional & scientific | 2015 |
| SNA Cityzip Ltd | Transport & logistics | 2026 |
| Snatch Cart Ltd | Wholesale & retail | 2024 |
| Snecom Limited | Extraterritorial | 2022 |
| Sniped Ltd | Information & communication | 2025 |
| Snooze Sleep World Ltd | Wholesale & retail | 2023 |
| Snoozeology Ltd | Wholesale & retail | 2024 |
| Snorll Limited | Real estate | 2026 |
| Snover Construction Limited | Construction | 2022 |
| Snowbridge Healthcare Ltd | Health & social care | 2017 |
| Snowglobe Interactive Ltd | Information & communication | 2024 |
| Snpharm Ltd | Health & social care | 2019 |
| Sntv Limited | Professional & scientific | 2024 |
| Snugdem Boogums Limited | Wholesale & retail | 2019 |
| SO Good World Ltd | Financial services | 2026 |
| SO Goodly Co Ltd | Manufacturing | 2025 |
| So-Holding Group Ltd | Real estate | 2021 |
| So-Recruit Ltd | Administrative & support | 2024 |
| So-Trak Ltd | Administrative & support | 2019 |
| Soakmill Bathrooms Ltd | Wholesale & retail | 2021 |
| Soap School Ltd | Manufacturing | 2013 |
| Social Homes Maintenance LLP | | 2013 |
| Social Progress Limited | Information & communication | 2011 |
| Social Publishing Limited | Information & communication | 2018 |
| Socialites Retail Limited | Wholesale & retail | 2014 |
| Socrates Psychological Services Ltd | Health & social care | 2007 |
| Sofia Mini Market Ltd | Wholesale & retail | 2026 |
| Soft Dreams(Uk) Ltd | Manufacturing | 2020 |
| Soft Look Ltd | Wholesale & retail | 2023 |
| Soft Touch Solutions Ltd | Information & communication | 2026 |
| Softaims Limited | Manufacturing | 2023 |
| Softcom Limited | Information & communication | 2022 |
| Soghaat Gifts & Fragrances Ltd | Wholesale & retail | 2024 |
| Soghaat Ltd | Extraterritorial | 2024 |
| Soghaat Online Ltd | Extraterritorial | 2024 |
| Soghaat X Ltd | Extraterritorial | 2024 |
| SOH1L Limited | Real estate | 2026 |
| Sohail Jewellers Ltd | Manufacturing | 2026 |
| Sokkit Ltd | Construction | 2023 |
| SOL Group West Yorkshire Ltd | Financial services | 2024 |
| Solani Limited | Public administration | 2021 |
| Solar Energise Limited | Manufacturing | 2013 |
| Solar Glazing Ltd | Manufacturing | 2020 |
| Solar Security Limited | Other services | 2022 |
| Solar Shade Blinds (Bespoke) Ltd | Manufacturing | 2025 |
| Solar Superstore Ltd | Professional & scientific | 2026 |
| Solaris 84 Estates Ltd | Real estate | 2025 |
| Solaris 84 Ltd | Health & social care | 2019 |
| Solarshade Window Films & Graphics Limited | Manufacturing | 2019 |
| Sole Layers Ltd | Manufacturing | 2026 |
| Solematch Ltd | Wholesale & retail | 2025 |
| Solid Education Ltd | Education | 2024 |
| Soliderma Ltd | Health & social care | 2019 |
| Solidsrc Limited | Information & communication | 2017 |
| Soliman Locums Limited | Real estate | 2010 |
| Soll AP Limited | Wholesale & retail | 2018 |
| Solo Satellite Communications Ltd | Information & communication | 1996 |
| Solo Wood Services Limited | Construction | 2015 |
| Solos Restaurant Ltd | Hospitality | 2023 |
| Solstia Ltd | Wholesale & retail | 2026 |
| Solutions Accountancy and Bookkeeping Limited | Professional & scientific | 2009 |
| Solve Advisors UK Ltd | Information & communication | 2020 |
| SOM Lockwood Limited | Hospitality | 2022 |
| SOM Lockwood Trading Limited | Hospitality | 2022 |
| Somac Limited | Professional & scientific | 1993 |
| Somar Consulting Ltd | Professional & scientific | 2025 |
| Somethinghot Limited | Wholesale & retail | 2024 |
| Somlie Limited | Financial services | 2014 |