| Skin and Beauty Centre Ltd | Other services | 2018 |
| Skin Perfection HD Ltd | Health & social care | 2024 |
| Skin Physicians Limited | Health & social care | 2022 |
| Skin Solutions (TLC) Ltd | Other services | 2014 |
| Skin Suite Aesthetics & Training Ltd | Health & social care | 2020 |
| Skinovation Huddersfield Ltd | Other services | 2024 |
| Sknz Limited | Water & waste | 2023 |
| Skwj Unlimited | Financial services | 2024 |
| Sky Echlipse Holding Ltd | Wholesale & retail | 2026 |
| Sky Executive Chauffeur Ltd | Transport & logistics | 2024 |
| Sky Global Shipping Ltd | Administrative & support | 2020 |
| Sky High Designs Ltd | Information & communication | 2026 |
| Sky Shop Huddersfield Ltd | Wholesale & retail | 2026 |
| Sky Stars Trading Ltd | Wholesale & retail | 2021 |
| Sky Vision Designs Ltd | Other services | 2024 |
| Sky-High Social Care Support and Consultancy Ltd | Health & social care | 2023 |
| SKY13 Ltd | Real estate | 2021 |
| Skybit Ltd | Other services | 2024 |
| Skybridge Developments Limited | Real estate | 2006 |
| Skydweller One Limited | Professional & scientific | 2019 |
| Skye Facilities Ltd | Administrative & support | 2017 |
| Skyechlipse Ltd | Administrative & support | 2024 |
| Skyehome Investments Ltd | Health & social care | 2022 |
| Skyetex Limited | Wholesale & retail | 2019 |
| Skyfire Labs Ltd | Wholesale & retail | 2023 |
| Skylines Services Ltd | Other services | 2020 |
| Skynet Digital Agency Ltd | Information & communication | 2024 |
| Skyreach Media Limited | Information & communication | 2009 |
| Skyride Travels Ltd | Wholesale & retail | 2023 |
| Skyrise Contractors Limited | Construction | 2025 |
| Skystars Traders Limited | Wholesale & retail | 2023 |
| Skywall Photography Ltd | Professional & scientific | 2020 |
| Skyways Global Travel Ltd | Administrative & support | 2026 |
| Skywayz Properties Ltd | Real estate | 2020 |
| SL Mortgage and Protection Ltd | Financial services | 2026 |
| SL Tiling Limited | Construction | 2015 |
| Sl-Ect Limited | Information & communication | 2007 |
| Slaitewaite Agricultural and Plant Ltd | Agriculture & fishing | 2026 |
| Slaithwaite Brass Band | Arts & recreation | 2011 |
| Slaithwaite Brass Band (Trading) Limited | Hospitality | 2011 |
| Slaithwaite Equitable Industrial SOC Ltd | Real estate | 2025 |
| Slaithwaite Foot Clinic Ltd | Health & social care | 2021 |
| Slaithwaite Moonraking Festival | Arts & recreation | 2011 |
| Slaithwaite Self Storage Ltd | Other services | 2017 |
| Slaiyburn Financial Planning Limited | Financial services | 2009 |
| Slant Marketing Ltd | Other services | 2023 |
| Slawit Spice HD7 Ltd | Hospitality | 2022 |
| Slawit Spice Ltd | Hospitality | 2026 |
| Sleep Haven Beds Limited | Manufacturing | 2026 |
| Sleep Mode Ltd | Manufacturing | 2023 |
| Sleep Relax Limited | Manufacturing | 2021 |
| Sleepova Ltd | Wholesale & retail | 2020 |
| Sleigh Services Ltd | Health & social care | 2019 |
| SLG Training & Consultancy Ltd | Professional & scientific | 2023 |
| Slic Innovations Limited | Extraterritorial | 2011 |
| Slice Foods Limited | Hospitality | 2024 |
| SLM Optics Ltd | Wholesale & retail | 2013 |
| SLP Engineering (UK) Limited | Professional & scientific | 2012 |
| SLS Architects Ltd | Professional & scientific | 2014 |
| SM (Locum) Ltd | Health & social care | 2008 |
| SM Capital Holdings Ltd | Wholesale & retail | 2025 |
| SM Dental Ltd | Health & social care | 2021 |
| SM Electrical & Security Limited | Construction | 2017 |
| SM Industry Ltd | Wholesale & retail | 2019 |
| SM Locums (Yorkshire) Ltd | Professional & scientific | 2015 |
| SM Vision Optics Ltd | Health & social care | 2026 |
| Sm&Pe Ltd | Hospitality | 2025 |
| SMA Healthcare Ltd | Professional & scientific | 2023 |
| Smak SPV Ltd | Real estate | 2025 |
| Small Business Nanny Ltd | Professional & scientific | 2008 |
| Smart Accounts & Tax Ltd | Professional & scientific | 2015 |
| Smart Bookkeeping & Payroll Ltd | Professional & scientific | 2019 |
| Smart Builders West Yorkshire Limited | Construction | 2024 |
| Smart Cars (Hudd) Ltd | Transport & logistics | 2019 |
| Smart Chidi Ltd | Health & social care | 2020 |
| Smart Developments (West Yorkshire) Ltd | Construction | 2023 |
| Smart Dream Limited | Real estate | 2014 |
| Smart Eire Cleaning Specialists Ltd | Administrative & support | 2022 |
| Smart Green Devices Ltd | Wholesale & retail | 2022 |
| Smart Kids Huddersfield Ltd | Health & social care | 2017 |
| Smart Law Solicitors Limited | Professional & scientific | 2022 |
| Smart Link Property Management Ltd | Real estate | 2025 |
| Smart Management Solutions (UK) Limited | Professional & scientific | 2007 |
| Smart MOT Ltd | Wholesale & retail | 2025 |
| Smart Projects Limited | Wholesale & retail | 2014 |
| Smart Property Solutions (Yorkshire) Limited | Construction | 2016 |
| Smart Sellers Hudds Ltd | Wholesale & retail | 2023 |
| Smart Serving Yorkshire Limited | Information & communication | 2018 |
| Smart Smart Move Ltd | Wholesale & retail | 2016 |
| Smart Splash Trading Ltd. | Wholesale & retail | 2021 |
| Smart Takeaways Limited | Information & communication | 2015 |
| Smart Trades North Ltd | Construction | 2002 |
| Smart Travel 247 Ltd | Transport & logistics | 2025 |
| Smart. Same Day Ltd | Transport & logistics | 2019 |
| Smartew Ltd | Wholesale & retail | 2025 |
| Smartfix & Lifestyle Ltd | Wholesale & retail | 2026 |
| Smartfix Gadgets & Gear Ltd | Wholesale & retail | 2025 |
| Smartgen Retail Ltd | Wholesale & retail | 2026 |
| Smartlifeproducts Ltd | Wholesale & retail | 2022 |
| Smartmart International Ltd | Wholesale & retail | 2026 |