| Somuchb Ltd | Construction | 2021 |
| Sona Life Limited | Wholesale & retail | 2021 |
| Sonah Services Limited | Professional & scientific | 2022 |
| Sonday Limited | Real estate | 2021 |
| Sonex Cookware Ltd | Wholesale & retail | 2025 |
| Soni Beauty Clinic Ltd | Other services | 2026 |
| Sonic Solutions Limited | Administrative & support | 2004 |
| Sonospark Imaging Limited | Health & social care | 2026 |
| Sonovis Limited | Health & social care | 2010 |
| Sopa Creativa CIC | Arts & recreation | 2025 |
| Sophel Limited | Health & social care | 2021 |
| Sophia's Closet Limited | Wholesale & retail | 2025 |
| Sophie Traynor Photography Ltd | Professional & scientific | 2020 |
| Sorelleofficial Ltd | Wholesale & retail | 2025 |
| Sorted Marketing Ltd | Professional & scientific | 2025 |
| SOS Auto Care Ltd | Wholesale & retail | 2020 |
| Souki Ltd | Wholesale & retail | 2023 |
| Soul Cafe Kitchen & Bar Ltd | Hospitality | 2025 |
| Soul Cairn CIC | Health & social care | 2025 |
| Soul for Screen Ltd. | Information & communication | 2018 |
| Soulsync HR Ltd | Administrative & support | 2025 |
| Sound & Light UK Limited | Manufacturing | 2009 |
| Sound and Light Concepts Limited | Manufacturing | 2007 |
| Sound Culture Ltd. | Information & communication | 2004 |
| Sounded Ltd | Information & communication | 2013 |
| Soundfields Solutions Limited | Wholesale & retail | 2015 |
| Soundscape AAC Ltd | Health & social care | 2025 |
| Source Creations Ltd | Wholesale & retail | 2020 |
| Source Universal Ltd | Wholesale & retail | 2020 |
| Source Visualisation Limited | Professional & scientific | 2011 |
| Soutenir Consulting Ltd | Professional & scientific | 2022 |
| South Leeds Leisure Limited | Arts & recreation | 1999 |
| South Leeds Team Ministry Charity Limited | Health & social care | 1983 |
| South Pennines Digital Towns CIC | Information & communication | 2021 |
| South Yorkshire Heart Clinic Ltd | Health & social care | 2021 |
| Southern Wind (Birmingham) Limited | Extraterritorial | 2021 |
| Southern Wind Group Limited | Hospitality | 2021 |
| Southport Teams Ltd | Real estate | 2025 |
| Sova Haven Ltd | Wholesale & retail | 2025 |
| Sovereign Auto Enrolment Solutions Limited | Financial services | 2015 |
| Sovereign Estates Huddersfield Ltd | Real estate | 2025 |
| Sowerby Pulls Ltd | Health & social care | 2020 |
| SP Body Sculpting Limited | Other services | 2022 |
| SP Healthcare Consulting Ltd | Health & social care | 2024 |
| SP Post Ltd | Information & communication | 2013 |
| SP Service Solutions Limited | Information & communication | 2011 |
| SP Surgical Limited | Health & social care | 2015 |
| Space and Bricks Ltd | Real estate | 2023 |
| Space and Bricks Management Ltd | Real estate | 2025 |
| Space IT Solutions Ltd | Information & communication | 2023 |
| Space Outdoor Estates Limited | Real estate | 2020 |
| Spakz Consults Limited | Other services | 2018 |
| Spakz P Ltd | Health & social care | 2019 |
| Spangled Bull Kirkheaton Ltd | Hospitality | 2023 |
| Sparetime Ltd | Information & communication | 2020 |
| Spark Hall Court Management Company Ltd | Households | 2017 |
| Sparking Potential Ltd | Professional & scientific | 2025 |
| Sparkle Rooms Limited | Other services | 2009 |
| Sparkle Signature Ltd | Administrative & support | 2026 |
| Sparkles Car Wash Ltd | Administrative & support | 2016 |
| Sparsh & Sell Limited | Other services | 2024 |
| Spartan Classic EV Limited | Extraterritorial | 2022 |
| Spartan Property MM Limited | Real estate | 2025 |
| SPC Support Ltd | Public administration | 2023 |
| Speak English Radio Limited | Information & communication | 2017 |
| Spear Telemarketing Ltd | Administrative & support | 2010 |
| Special Buys Limited | Wholesale & retail | 2023 |
| Special Event Bars Limited | Hospitality | 2012 |
| Special Event Catering Limited | Hospitality | 2021 |
| Specialed MUM Ltd | Wholesale & retail | 2021 |
| Specialist Timber and Stone Services Limited | Construction | 2021 |
| Specjaly Ltd | Wholesale & retail | 2023 |
| Spectacular Eyewear Limited | Wholesale & retail | 2017 |
| Spectrum Bodyworx Ltd | Wholesale & retail | 2018 |
| Speed and Movement Ltd | Wholesale & retail | 2015 |
| Speedwell Family Healthcare Limited | Health & social care | 2014 |
| Speedx Technologies Limited | Wholesale & retail | 2025 |
| Speleouk Ltd | Construction | 2019 |
| Spen Valley Active Schools CIC | Arts & recreation | 2024 |
| Spencer Taylor Limited | Administrative & support | 2003 |
| Spencers Joinery Limited | Construction | 2017 |
| SPH Pharma Ltd | Health & social care | 2024 |
| Sphd Huddersfield Limited | Other services | 2016 |
| Sphereshop Ltd | Wholesale & retail | 2024 |
| Spice House (Berrybrow) Ltd | Hospitality | 2024 |
| Spice Ranch Ltd | Hospitality | 2018 |
| Spice Tandem Ltd | Hospitality | 2021 |
| Spicy HUT (HUD) Ltd | Hospitality | 2022 |
| Spicy Kitchen Marsh Limited | Hospitality | 2023 |
| Spider Rider Ltd | Information & communication | 2021 |
| Spike Estates Limited | Real estate | 1998 |
| Spilled Colours Ltd | Construction | 2025 |
| Spin & DRY Ltd | Other services | 2015 |
| Spindle ROW Management Company Ltd | Households | 2026 |
| Spinneyfield Limited | Real estate | 2000 |
| Spiral Analysis Limited | Information & communication | 2007 |
| Spiral Medical Ltd | Extraterritorial | 2006 |
| Spirit of Concorde Limited | Information & communication | 2015 |
| Spirited Medical Ltd | Health & social care | 2023 |
| Spivey Waste Management Limited | Water & waste | 2002 |