| Serenova Studios Ltd | Information & communication | 2024 |
| Serroch Limited | Real estate | 2022 |
| Service Engineering CNC Limited | Manufacturing | 2002 |
| Servicesellpro Limited | Information & communication | 2026 |
| SES Imaging Ltd | Health & social care | 2022 |
| Sethiz Services Ltd | Financial services | 2019 |
| Seven by Four Ltd | Wholesale & retail | 2018 |
| Seven Magpies Property Holdings Limited | Real estate | 2023 |
| Seven Oceans Business Support Limited | Administrative & support | 2014 |
| Seventy Acre Farm Management Limited | Households | 2025 |
| SEVENTY1 Digital Ltd | Information & communication | 2014 |
| SEZ Distribution Limited | Transport & logistics | 2020 |
| SF GP Ltd | Health & social care | 2018 |
| SFA Smiles Ltd | Health & social care | 2021 |
| Sfis Investments Ltd | Real estate | 2026 |
| SFK HD Ltd | Wholesale & retail | 2026 |
| SG Commercial Services Limited | Professional & scientific | 2016 |
| SGM Structural Design Limited | Professional & scientific | 2005 |
| SGT Advisory Limited | Professional & scientific | 2025 |
| SH Car Valeting Ltd | Administrative & support | 2025 |
| SH Domestics Ltd | Construction | 2018 |
| SH Electrical MCR Ltd | Construction | 2023 |
| SH Ophthalmic Services Limited | Health & social care | 2004 |
| SH Private Hire Ltd | Transport & logistics | 2024 |
| SH Realty Ltd | Real estate | 2026 |
| SH Smiles Ltd | Health & social care | 2026 |
| Sh&Hs Healthcare Ltd | Health & social care | 2022 |
| SH3Y Ltd | Professional & scientific | 2018 |
| Shaadi Superstore Ltd | Wholesale & retail | 2016 |
| Shaam Spice Ltd | Hospitality | 2018 |
| Shabeer Limited | Transport & logistics | 2026 |
| Shabina ALI Limited | Health & social care | 2019 |
| Shabnam Cloth House Ltd | Wholesale & retail | 2022 |
| Shade Tree Ltd | Real estate | 2018 |
| Shaf 'S Spice Ltd | Hospitality | 2026 |
| Shafi and Bros Limited | Financial services | 2025 |
| Shagai Holdings Ltd | Construction | 2020 |
| Shah Logistics Services Ltd | Wholesale & retail | 2022 |
| Shah Real Estate Victoria Ltd | Construction | 2025 |
| Shah Super EB Ltd | Wholesale & retail | 2026 |
| Shahoor Limited | Wholesale & retail | 2025 |
| Shahzadi Fashion Ltd | Wholesale & retail | 2022 |
| Shahzain Enterprise Ltd | Wholesale & retail | 2026 |
| Shak Cars Ltd | Transport & logistics | 2023 |
| Shak's Snooty's Pizza Ltd | Hospitality | 2026 |
| Shaks Specialist Cars Ltd | Wholesale & retail | 2004 |
| Sham Gross Limited | Wholesale & retail | 2024 |
| Shama Huddersfield Limited | Hospitality | 2024 |
| Shamritha Ltd | Wholesale & retail | 2018 |
| Shamrock Import and Export UK Limited | Transport & logistics | 2007 |
| Shamtaj Ltd | Wholesale & retail | 2021 |
| Shana Sohal Ltd | Health & social care | 2023 |
| Shandong Ruyi UK Limited | Wholesale & retail | 2016 |
| Shanelan Limited | Professional & scientific | 2021 |
| Shangara's Property Ltd | Construction | 2021 |
| Shanghai Huang Ltd | Hospitality | 2021 |
| Shanghai Takeaway Ltd | Hospitality | 2015 |
| Shape Lindley C.I.C. | Education | 2014 |
| Shapemaster Global Limited | Manufacturing | 1997 |
| Shaping Care in Kirklees CIC | Health & social care | 2021 |
| Shaping Futures Childcare Ltd | Health & social care | 2024 |
| Sharc Retail (Kirkburton) Limited | Wholesale & retail | 2020 |
| Sharc Trading Limited | Wholesale & retail | 2019 |
| Shard Investments Ltd | Financial services | 2018 |
| Share Academy Trust | Education | 2015 |
| Share Multi Academy Trust | Education | 2011 |
| Share One Limited | Hospitality | 2017 |
| Shareefain Ltd | Wholesale & retail | 2021 |
| Sharif Property Management Co. Ltd | Real estate | 2023 |
| Sharkys Fish Bar Limited | Hospitality | 2019 |
| Sharman Accountancy Limited | Professional & scientific | 2016 |
| Sharp Holdings (Surrey) Limited | Financial services | 2026 |
| Sharron Parr RDH Ltd | Health & social care | 2012 |
| Shaw Pallet (Holdings) Limited | Professional & scientific | 2007 |
| Shaw Pallet Limited | Manufacturing | 1973 |
| Shaw Pallets Group Limited | Financial services | 2022 |
| Shaw Timber (Holdings) Limited | Professional & scientific | 2008 |
| Shaw Timber Group Limited | Financial services | 2023 |
| Shaw Timber Limited | Manufacturing | 1976 |
| Shaw&Plant Properties Ltd | Real estate | 2024 |
| Shawarma Point Ltd | Hospitality | 2025 |
| Shawarma Point Tandoori Ltd | Hospitality | 2025 |
| Shawcrest Water Treatment Limited | | 1981 |
| Shaws (Huddersfield) Limited | Manufacturing | 1902 |
| Shax Tasty Food Ltd | Hospitality | 2018 |
| Shaz Taxis Ltd | Transport & logistics | 2025 |
| Shbee Ltd | Hospitality | 2024 |
| Sheards Financial Management Ltd | Professional & scientific | 2019 |
| Shed Central Ltd | Health & social care | 2015 |
| Shedway Ltd | Wholesale & retail | 2023 |
| Sheehan Property Limited | Real estate | 2016 |
| Sheenas Skin and Smiles Ltd | Health & social care | 2021 |
| Sheepridge Chippy Ltd | Hospitality | 2019 |
| Sheepridge OFF Licence Limited | Wholesale & retail | 2008 |
| Sheerspire Limited | Administrative & support | 1979 |
| Sheetal Kumar Ltd | Transport & logistics | 2026 |
| Shehzad Property Solutions Ltd | Financial services | 2025 |
| Shelf Hair and Beauty Limited | Other services | 2012 |
| Shelf Space PVT Ltd | Transport & logistics | 2023 |
| Shelley Automation Limited | Wholesale & retail | 1997 |