| Shelley Community Association | Other services | 2012 |
| Shelley Community Football Limited | Arts & recreation | 2011 |
| Shelley Marketing Consultancy Ltd | Extraterritorial | 2015 |
| Shepherd Property Ltd | Real estate | 2017 |
| Shepherds Arms Cowcliffe Ltd | Hospitality | 2023 |
| Shepley Cricket Club Leisure Limited | Hospitality | 2025 |
| Shepley Phase 1 Management Company Limited | Households | 2021 |
| Shepley Phase 2 Management Company Limited | Households | 2026 |
| Shepley Primary Care Limited | Health & social care | 2022 |
| Shepley Spring Limited | Manufacturing | 1996 |
| Sherburn Estates Limited | Real estate | 2003 |
| Sherpa Ventures 360 Limited | Construction | 2022 |
| Sherry King Consulting Limited | Professional & scientific | 2023 |
| Sherry's Travel Limited | Transport & logistics | 1992 |
| Shers Trading Ltd | Wholesale & retail | 2025 |
| Shez Associates Ltd | Administrative & support | 2017 |
| SHF Digital Consulting Ltd | Information & communication | 2025 |
| Shield Coatings Ltd | Manufacturing | 1996 |
| Shield Yourself Ltd | Financial services | 2024 |
| Shift Quick Performance Ltd | Wholesale & retail | 2022 |
| Shiimmer Ltd | Manufacturing | 2021 |
| Shilla Ltd | Wholesale & retail | 2025 |
| Shilp Studio UK Limited | Arts & recreation | 2010 |
| Shipico Ltd | Construction | 2026 |
| Shiraz Zagros Ltd | Hospitality | 2022 |
| Shire Link Limited | Administrative & support | 1981 |
| Shire Property (Yorkshire) Ltd | Real estate | 2018 |
| Shirerose Limited | | 1988 |
| Shoaib Travel Ltd | Transport & logistics | 2025 |
| Shoe Direct Ltd | Wholesale & retail | 2014 |
| Shoks Logistics Ltd | Transport & logistics | 2023 |
| Shop Above Ltd | Wholesale & retail | 2022 |
| Shop and Learn Limited | Education | 2024 |
| Shop Cosy Corner Limited | Wholesale & retail | 2025 |
| Shop Paving Ltd | Wholesale & retail | 2025 |
| Shop Peacefully Ltd | Wholesale & retail | 2025 |
| Shop the Ideal Limited | Wholesale & retail | 2025 |
| Shop With SAI Ltd | Wholesale & retail | 2023 |
| SHOP4 Security & Electrical Limited | Wholesale & retail | 2003 |
| Shopaholic Store Ltd | Wholesale & retail | 2023 |
| Shopfic Ltd | Wholesale & retail | 2024 |
| Shopforplates Ltd | Information & communication | 2025 |
| Shophive Limited | Wholesale & retail | 2023 |
| Shopitall Hudds Ltd | Wholesale & retail | 2023 |
| Shopndcart Ltd | Wholesale & retail | 2024 |
| Shopnexus Ltd | Wholesale & retail | 2025 |
| Shopping Experts Ltd | Wholesale & retail | 2017 |
| Shopping JET Ltd | Wholesale & retail | 2024 |
| Shops and Stop Ltd | Wholesale & retail | 2026 |
| Shopscape Ltd | Professional & scientific | 2024 |
| Shorelight Properties Ltd | Real estate | 2025 |
| Shoreline YCC Ltd | Health & social care | 2019 |
| Shoto Holdings Limited | Administrative & support | 2025 |
| Shoubiao Ltd | Wholesale & retail | 2025 |
| Shree Laxmi Ltd | Manufacturing | 2021 |
| Shri Logistics Ltd | Transport & logistics | 2025 |
| Shriji Beauty Touch Ltd | Other services | 2025 |
| Shriji SAI Enterprise Ltd | Wholesale & retail | 2022 |
| Shrinathji Ltd | Wholesale & retail | 2026 |
| SHT Consultancy Services Ltd | Professional & scientific | 2024 |
| SHY Vision Ltd | Health & social care | 2022 |
| SI 6 Limited | Wholesale & retail | 2024 |
| SI Locum Yokrshire Ltd | Health & social care | 2024 |
| SI Trade Deals Ltd | Wholesale & retail | 2021 |
| Sickle Sanctuary Ltd | Education | 2026 |
| Sid&Richard Ltd | Wholesale & retail | 2024 |
| Siddique Estates Limited | Real estate | 2024 |
| Sideloader Services Limited | Other services | 1983 |
| Sidestep Ltd | Information & communication | 2018 |
| Sidneys Trade Co Ltd | Construction | 2021 |
| Sids Cafe Limited | Hospitality | 2009 |
| Sierra Property Group Ltd | Real estate | 2025 |
| Sifa Limited | Administrative & support | 1992 |
| SIGMA1247 Ltd | Real estate | 2025 |
| Sigmatax 2018 Limited | Professional & scientific | 2018 |
| Sigmatax Ltd | Professional & scientific | 2024 |
| Signature Balloons Ltd | Wholesale & retail | 2019 |
| Signature Homes (Yorkshire) Ltd | Construction | 2010 |
| Signature Power Limited | Construction | 2025 |
| Signature Scalp Ltd | Other services | 2023 |
| Signature Trades Ltd | Wholesale & retail | 2022 |
| Signature Upholstery Limited | Manufacturing | 2021 |
| Signpost Holdings Limited | Construction | 2019 |
| Sikh Soldier Organisation CIC | Other services | 2019 |
| Siky Limited | Wholesale & retail | 2015 |
| Silcoates Garage Limited | Wholesale & retail | 2007 |
| Silk School of Dance Limited | Education | 2021 |
| Silkstone Pre-School Playgroup Limited | Education | 2002 |
| Silver Carr Limited | Financial services | 2025 |
| Silver Consulting (Human Resource Partners) Limited | Administrative & support | 2001 |
| Silver Lining Huddersfield Ltd | Wholesale & retail | 2014 |
| Silver Lining Nottingham Ltd | Wholesale & retail | 2019 |
| Silver Lining Piercing & Jewellery Ltd | Wholesale & retail | 2013 |
| Silver Lining Sheff Ltd | Wholesale & retail | 2018 |
| Silver Lining York Ltd | Wholesale & retail | 2017 |
| Silver Rock Investments Ltd | Real estate | 2016 |
| Silver Shadows Gallery Ltd | Wholesale & retail | 2016 |
| Silver Smith Properties Limited | Real estate | 2019 |
| Silver Spring Ltd | Real estate | 2020 |
| Silver Street Engineering Limited | Financial services | 2019 |