| Scapetech Limited | Professional & scientific | 2003 |
| Scar Bottom Management Company Limited | Households | 2024 |
| SCB Installations Limited | Construction | 2005 |
| Scent Connect Ltd | Wholesale & retail | 2026 |
| Scent Decants Ltd | Wholesale & retail | 2022 |
| Scentastic Ltd | Wholesale & retail | 2020 |
| SCF Properties Limited | Real estate | 2008 |
| SCG Consulting (UK) Limited | Professional & scientific | 2018 |
| SCH Commercial Properties Limited | Real estate | 2014 |
| SCH Renewable Energies Limited | Construction | 2014 |
| Schemelocal Limited | Real estate | 1991 |
| Schilling Solutions Limited | Real estate | 2024 |
| Schofield & Smith (Holdings) Limited | Professional & scientific | 1996 |
| Schofield Reclamation Limited | Wholesale & retail | 1981 |
| Scholari Consulting Limited | Information & communication | 2024 |
| School Club Limited | Wholesale & retail | 2015 |
| School of Scholars Ltd | Education | 2025 |
| Schoolbusclub.Com Limited | Transport & logistics | 2025 |
| Schoolwiz Ltd | Information & communication | 2020 |
| Schosween 60 Limited | Professional & scientific | 2014 |
| Scientific Lubricants Limited | Wholesale & retail | 1970 |
| Scissett DIY Limited | Wholesale & retail | 2021 |
| Scissett Kids Club Limited | Health & social care | 2020 |
| Scissett Recruitment Group Limited | Administrative & support | 2018 |
| Scklr Limited | Hospitality | 2026 |
| SCM Turbomotive Limited | Wholesale & retail | 1995 |
| SCM Turbomotive Trustees Limited | Administrative & support | 2022 |
| SCN Recycling Limited | Wholesale & retail | 2025 |
| Scope Analytics Ltd | Information & communication | 2021 |
| Scopol Properties Limited | Real estate | 2019 |
| Scorpio Computers Limited | Information & communication | 2002 |
| Scott and SON Properties Limited | Real estate | 2025 |
| Scottfield Properties Ltd | Real estate | 2022 |
| Scotty's Bars Ltd | Hospitality | 2024 |
| Scotty's Pet Supplies Ltd | Wholesale & retail | 2025 |
| Scout Renewables Limited | Information & communication | 2026 |
| Scrahallia Limited | Real estate | 2014 |
| Screedpro Group Limited | Construction | 2020 |
| Scrubs&Rugs Limited | Administrative & support | 2025 |
| Scsgroundworks Ltd | Construction | 2024 |
| Scukco Ltd | Information & communication | 2018 |
| Scutum Labs Ltd | Financial services | 2023 |
| SDC Consultants (Yorkshire) Ltd | Professional & scientific | 2020 |
| Sddb Ltd | Hospitality | 2023 |
| Sdeen Invests Ltd | Real estate | 2024 |
| Sdoc Limited | Health & social care | 2011 |
| SDQ Store Ltd | Wholesale & retail | 2024 |
| Sea Pearl & C Ltd | Manufacturing | 2019 |
| Seablossom Limited | Professional & scientific | 2022 |
| Seamless Bathrooms Ltd | Construction | 2023 |
| Seamless Daily Ltd | Information & communication | 2020 |
| Seanpong Tyres Ltd | Wholesale & retail | 2014 |
| Seapharma Nutrition Ltd | Manufacturing | 2026 |
| Seasalt Cottages Ltd | Real estate | 2024 |
| Seasonal Gifts Ltd | Wholesale & retail | 2021 |
| Seatable (UK) Limited | Wholesale & retail | 2005 |
| SEC Yorkshire Ltd | Construction | 2021 |
| Seco Enterprise Ltd | Wholesale & retail | 2011 |
| Second Binomial | Administrative & support | 1970 |
| Secret Horizons Ltd | Administrative & support | 2025 |
| Secret Self Storage Ltd | Transport & logistics | 2017 |
| Secure Premises Ltd | Transport & logistics | 2023 |
| Secure Travel Ltd | Transport & logistics | 2024 |
| Secured Property Investments Limited | Construction | 2015 |
| Securenest Services Ltd | Administrative & support | 2026 |
| Securepoint Fire and Security Ltd | Construction | 2025 |
| Secureseal Systems Limited | Administrative & support | 2003 |
| SEE YOU at Home Ltd | Wholesale & retail | 2013 |
| Seeds Holdings Limited | Financial services | 2023 |
| Seetheproof Ltd | Wholesale & retail | 2025 |
| Seika Health Ltd | Health & social care | 2024 |
| Sekuntum Limited | Extraterritorial | 2022 |
| Select Breakfast Ltd | Hospitality | 2022 |
| Select Kitchens Yorkshire Limited | Wholesale & retail | 2018 |
| Select Lawncare Limited | Other services | 2006 |
| Self Love & Mindset Mastery C.I.C. | Education | 2026 |
| Selknam UK Limited | Manufacturing | 2023 |
| Sellerlab Ltd | Information & communication | 2026 |
| Sellers International Limited | Professional & scientific | 1978 |
| Sellers Textile Engineers Limited | Manufacturing | 2019 |
| Sellers Yorkshire Limited | Professional & scientific | 1991 |
| Selling Zone Ltd | Wholesale & retail | 2026 |
| Selo Source Limited | Wholesale & retail | 2022 |
| Selpack Limited | Manufacturing | 2023 |
| SEM Landlord Services Ltd | Real estate | 2018 |
| SEM Networks Ltd | Wholesale & retail | 2024 |
| Semfem Events Limited | Hospitality | 2025 |
| Semper AMA Ltd | Real estate | 2023 |
| Senior Electrical Limited | Construction | 2005 |
| Senior Elite Performance Services Ltd | Health & social care | 2017 |
| Senmarine Limited | Professional & scientific | 2023 |
| Sensorae Limited | Wholesale & retail | 2024 |
| Sentinel Fire Solutions Limited | Public administration | 2018 |
| Sentinelsecuregroup Ltd | Administrative & support | 2025 |
| Sentini Marine Limited | Professional & scientific | 2011 |
| Sentoria Ltd | Professional & scientific | 2025 |
| Serah Netfence Ltd | Information & communication | 2025 |
| Serell Eco Clean Ltd | Wholesale & retail | 2026 |
| Serene Accommodation Solutions Limited | Health & social care | 2024 |
| Serene Finishing and Property Services Ltd | Construction | 2021 |