| Samack Residential Limited | Real estate | 2016 |
| Samara Locums Ltd | Health & social care | 2016 |
| Samba Holdings Ltd | Financial services | 2025 |
| Sambiam Global Ltd | Wholesale & retail | 2023 |
| Samcat Technologies Ltd | Information & communication | 2012 |
| Samdan Consulting (Asia) Limited | Professional & scientific | 2021 |
| Same Direction Limited | Transport & logistics | 2019 |
| Same Skies Think Tank CIC | Other services | 2022 |
| Sami Joseph Ltd | Real estate | 2023 |
| Samlogistics Ltd | Transport & logistics | 2025 |
| Samplus Limited | Wholesale & retail | 2011 |
| Sampson Cleaning LLP | | 2007 |
| Samson Fire Limited | Administrative & support | 2006 |
| Samson Investments Yorkshire Ltd | Real estate | 2003 |
| Samten Holdings Limited | Financial services | 2023 |
| Samuel's Cars Ltd | Transport & logistics | 2022 |
| Samy NW Ltd | Real estate | 2024 |
| Sanbha PVT Ltd | Health & social care | 2022 |
| Sandal Access Solutions Limited | Construction | 2018 |
| Sanderson & Cliff Limited | Construction | 2013 |
| Sanderson (Laboratory Systems) Limited | Manufacturing | 1971 |
| Sanderson Brothers (Inglewhite) Ltd | Manufacturing | 2011 |
| Sanderson Precision Engineering Limited | Professional & scientific | 1999 |
| Sandhu Enterprises 1 Ltd | Real estate | 2025 |
| Sandhu Family Enterprises Ltd | Real estate | 2024 |
| Sandhu Leisure LLP | | 2010 |
| Sandhu Property Limited | Real estate | 2015 |
| Sandil Express Ltd | Transport & logistics | 2024 |
| Sandringham Financial Partners Limited | Financial services | 2012 |
| Sangal Consulting Ltd | Professional & scientific | 2025 |
| Sangfor Technologies (UK) Limited | Extraterritorial | 2012 |
| Sanity (Yorkshire) Limited | Professional & scientific | 2011 |
| Sankofa Hair and Beauty Ltd | Wholesale & retail | 2020 |
| Sanna Kauser Ltd | Health & social care | 2025 |
| Santak Consultancy Services Ltd | Administrative & support | 2013 |
| Santino's Bite Ltd | Hospitality | 2025 |
| Santinos Pizza House Ltd | Hospitality | 2019 |
| Santo Medical Ltd | Wholesale & retail | 2025 |
| Santos Barbers Ltd | Other services | 2025 |
| SAO Financial Services Limited | Financial services | 2019 |
| Saphiara Ltd | Professional & scientific | 2016 |
| Saphire 1 Trading Ltd | Wholesale & retail | 2025 |
| Sapien Enterprises Limited | Health & social care | 2015 |
| Sapiens Consulting Ltd | Professional & scientific | 2025 |
| Sapient Elite Sports Limited | Administrative & support | 2021 |
| Sapori (Lindley) Limited | Hospitality | 2023 |
| Sapphire Care Group Ltd | Health & social care | 2025 |
| Saqib Meat Ltd | Wholesale & retail | 2025 |
| Sara Armitage Limited | Professional & scientific | 2009 |
| Sara Caie Limited | Education | 2023 |
| Sara Walters Developments Ltd | Wholesale & retail | 2014 |
| Sarah Rachel Photography Ltd | Professional & scientific | 2025 |
| Sarah’S Healthy Kitchen Ltd | Professional & scientific | 2019 |
| Sarfraz Healthcare Limited | Health & social care | 2012 |
| Sarif Locum Services Ltd | Health & social care | 2019 |
| Sarin Property Management Ltd | Real estate | 2020 |
| Sarvin Design Ltd | Manufacturing | 2020 |
| SAS 88 Housing Group Limited | Real estate | 2025 |
| Sasaz Limited | Wholesale & retail | 2024 |
| Sasco Capital Limited | Financial services | 2018 |
| Sasco Group Limited | Financial services | 2019 |
| Sasco Properties Limited | Real estate | 2013 |
| Sasquare Homes Limited | Construction | 2020 |
| Sass Wellbeing Ltd | Arts & recreation | 2024 |
| Sattar Limited | Manufacturing | 2026 |
| Sattar Properties (UK) Ltd | Real estate | 2024 |
| Sauda & Sons Ltd | Administrative & support | 2026 |
| SAV NAV Travel Ltd | Transport & logistics | 2023 |
| Savage Performance Coaching Ltd | Professional & scientific | 2024 |
| Savecastle | Administrative & support | 1976 |
| Saveorphanedpet Ltd | Wholesale & retail | 2024 |
| Savesales | Administrative & support | 1976 |
| Savetown | Administrative & support | 1976 |
| Savimi Limited | Information & communication | 2020 |
| Saving Grace Music CIC | Wholesale & retail | 2023 |
| Savoir Limited | Professional & scientific | 2025 |
| Savour's Bite Ltd | Hospitality | 2023 |
| Savvie Holdings Limited | Manufacturing | 2012 |
| Savvy Strike Ltd | Manufacturing | 2024 |
| Savvy Tech Solutions Ltd | Information & communication | 2024 |
| Savvycart Limited | Wholesale & retail | 2025 |
| Savvysouq Ltd | Wholesale & retail | 2023 |
| Sawdust and Splinters Ltd | Manufacturing | 2023 |
| Sawyer Consulting Engineers Limited | Professional & scientific | 2020 |
| Saxonwells Developments Limited | Construction | 2017 |
| SAY Motors Ltd | Wholesale & retail | 2018 |
| Saybi Ltd | Information & communication | 2010 |
| Saybi Medical Services Ltd | Health & social care | 2016 |
| SB & Sons Property Ltd | Real estate | 2023 |
| SB Business Solutions Limited | Administrative & support | 2005 |
| SB Coffee Ltd. | Wholesale & retail | 2025 |
| SB Energy Compliance Limited | Construction | 2019 |
| SBC Packaging Ltd | Transport & logistics | 2023 |
| SBS Medical Services Ltd | Health & social care | 2021 |
| SBU Optics Ltd | Health & social care | 2022 |
| SC Performance Ltd | Wholesale & retail | 2023 |
| SC1 Property Limited | Professional & scientific | 2019 |
| Scala Trustee Limited | Financial services | 2023 |
| Scalethree Ltd | Professional & scientific | 2026 |
| Scape Properties Limited | Real estate | 2021 |