| S.K.A. Textiles Limited | Manufacturing | 1985 |
| S.M Mpharm Ltd | Health & social care | 2022 |
| S.M.A Health Limited | Health & social care | 2016 |
| S.M.W. Associates Limited | Professional & scientific | 2001 |
| S.N.I Trader Limited | Wholesale & retail | 2024 |
| S.R.Electrical Ltd. | Construction | 2017 |
| S.S.A.T. Property Investments Limited | Administrative & support | 2013 |
| S2E Limited | Professional & scientific | 2023 |
| S3N Properties Ltd | Real estate | 2025 |
| SA (HD) Ltd | Hospitality | 2022 |
| SA and Associates Company Limited | Real estate | 2011 |
| SA and Co Holdings Ltd | Financial services | 2024 |
| SA Delivery Ltd | Hospitality | 2025 |
| SA Global PVT Ltd | Transport & logistics | 2026 |
| SA Legal Services Limited | Professional & scientific | 2024 |
| SA Merchants Limited | Wholesale & retail | 2026 |
| SA Service Solutions Ltd | Health & social care | 2018 |
| Saasd Ltd | Wholesale & retail | 2024 |
| Sabbeel Ltd | Wholesale & retail | 2023 |
| Sabii Global Ltd | Wholesale & retail | 2022 |
| Sable and Stone Ltd | Wholesale & retail | 2024 |
| Sablo Ltd | Arts & recreation | 2021 |
| Saboteur & Saviour Ltd | Arts & recreation | 2021 |
| Sabre Capital Ltd | Real estate | 2026 |
| Sackville (Barnsley) Management Company Limited | Real estate | 2008 |
| Sacred Routes Ltd | Administrative & support | 2025 |
| Sacred Studios (Liverpool) Ltd | Other services | 2021 |
| Sada E Madina Hajj & Umrah (UK) Ltd | Administrative & support | 2006 |
| Sadaqashop International Ltd | Wholesale & retail | 2024 |
| Sadcom Ltd | Financial services | 2023 |
| Saddleworth Brownies Ltd | Wholesale & retail | 2021 |
| Saeed & Mahmood Properties Ltd | Construction | 2025 |
| SAF Medical Services Ltd | Real estate | 2015 |
| SAF Property Investments Ltd | Real estate | 2017 |
| Safa Screening and Diagnostics Ltd | Health & social care | 2025 |
| Safe and Sound Storage Trading Ltd | Transport & logistics | 2023 |
| Safe and Sound Windows Yorkshire Ltd | Construction | 2023 |
| Safe CAB Ltd | Transport & logistics | 2025 |
| Safe Environmental Ltd | Professional & scientific | 2012 |
| Safe ENVIRONMENTAL2.0 Ltd | Professional & scientific | 2023 |
| Safe Mate Tech Ltd | Professional & scientific | 2026 |
| Safe Purchase Ltd | Wholesale & retail | 2026 |
| Safe Test UK Limited | Professional & scientific | 2005 |
| Safehaven Cleaning Services Ltd | Administrative & support | 2025 |
| Safekids Playhouse Limited | Education | 2024 |
| Safety Equipment Centre (Huddersfield) Limited | Transport & logistics | 1981 |
| Safety First Ice Cleats Limited | Wholesale & retail | 2011 |
| Saffron (Huddersfield) Ltd | Hospitality | 2015 |
| Saffron (Scissett) Ltd | Hospitality | 2023 |
| Saffrose Ltd | Wholesale & retail | 2023 |
| Safrex Pro Limited | Manufacturing | 2026 |
| Sage Restaurant Slaithwaite Ltd | Hospitality | 2025 |
| Sahaa Space Ltd | Arts & recreation | 2026 |
| Sahae Global Ltd | Health & social care | 2026 |
| Sahils Cricket Academy Ltd | Education | 2025 |
| Sahmadmedical Ltd | Health & social care | 2023 |
| Sahota Capital Ltd | Professional & scientific | 2022 |
| SAI Advisers Ltd | Health & social care | 2015 |
| Saicharan Ltd | Health & social care | 2021 |
| Saif Heating and Plumbing Solutions Ltd | Construction | 2026 |
| Saii 11 Limited | Wholesale & retail | 2021 |
| Saimaa Management Consulting Ltd | Professional & scientific | 2023 |
| Sain Supplies Ltd | Wholesale & retail | 2022 |
| Saira Hussain Ltd | Health & social care | 2015 |
| Saira NAZ Ltd | Health & social care | 2022 |
| Saira's Deli Limited | Hospitality | 2021 |
| Sairah Iqbal Ltd | Health & social care | 2017 |
| SAJ & Sons Lettings Ltd | Real estate | 2026 |
| SAJ Pervaiz Ltd | Financial services | 2025 |
| Sajad Khokhar Limited | Health & social care | 2013 |
| Sajeel Developments Ltd | Real estate | 2024 |
| Sajeel Ltd | Information & communication | 2023 |
| Sajid Rafiq Ltd | Professional & scientific | 2019 |
| SAK Accountants Limited | Professional & scientific | 2021 |
| SAK Property Services Ltd | Real estate | 2022 |
| Sakeenah Enterprise Ltd | Wholesale & retail | 2023 |
| Sakhi PVT Ltd | Construction | 2025 |
| SAKHTAR1 Limited | Real estate | 2023 |
| Sal's Desserts Ltd | Hospitality | 2023 |
| Salaam Ltd | Wholesale & retail | 2023 |
| Salahpharm Ltd | Wholesale & retail | 2022 |
| Salamander Haskell Holdings Limited | Financial services | 2017 |
| Salamander Haskell Limited | Real estate | 2017 |
| Saleem Estates Limited | Real estate | 2022 |
| Saleem Property Leasing Ltd | Real estate | 2023 |
| Salendine Limited | Transport & logistics | 2012 |
| Sales Rocket Ltd | Information & communication | 2024 |
| Sales Universal Fashion Limited | Wholesale & retail | 2013 |
| Salford Public House Limited | Hospitality | 2015 |
| Sali Consulting Ltd | Administrative & support | 2020 |
| Salisburyfire Limited | Professional & scientific | 2017 |
| Salkamarit Limited | Information & communication | 2001 |
| Salon 365 Limited | Other services | 2010 |
| Salt N Pepper Ltd | Hospitality | 2021 |
| Salvador Payment Solutions Ltd | Professional & scientific | 2022 |
| Salvage Repair Services Ltd | Wholesale & retail | 2026 |
| Salvation - UK Limited | Professional & scientific | 2006 |
| SAM Thomas Ltd | Other services | 2021 |
| SAM Wilkinson Golf Ltd | Education | 2024 |
| Samack Limited | Real estate | 2015 |