| Ellodys Consultancy Limited | Information & communication | 2026 |
| ELM Grove Eastbourne Limited | Real estate | 2017 |
| Elmir Property Limited | Real estate | 2018 |
| Elnaugh Dent Limited | Health & social care | 2021 |
| Elontos Limited | Wholesale & retail | 2025 |
| ELS Estates Europe Limited | Real estate | 2025 |
| ELS Logistics Ltd | Transport & logistics | 2024 |
| ELS Solutions Ltd | Construction | 2022 |
| Elucidate Online Ltd | Information & communication | 2025 |
| Elworthy Media Ltd | Information & communication | 2021 |
| Elysium Business Partners Limited | Professional & scientific | 2003 |
| Elysium Hotels Limited | Extraterritorial | 2003 |
| EM Search Partners Ltd | Administrative & support | 2018 |
| EM ZEE Dental Limited | Health & social care | 2026 |
| Em-Man Consulting Limited | Professional & scientific | 2008 |
| Emad Phone Ltd | Wholesale & retail | 2025 |
| Emarketing Developments Limited | Professional & scientific | 1998 |
| Ember Events Limited | Administrative & support | 2026 |
| EMC Corporate Finance Limited | Professional & scientific | 1989 |
| EMC Management Consultants Limited | Financial services | 1998 |
| Emdd Construction Ltd | Information & communication | 2017 |
| Emdp Holdings Limited | Health & social care | 2021 |
| Emerald Quay Freeholders Limited | Real estate | 1996 |
| Emerge Additive Ltd | Professional & scientific | 2023 |
| Emergency Cover Limited | Financial services | 2012 |
| Emergent Impact Ltd | Information & communication | 2023 |
| Emertec Ltd. | Information & communication | 2008 |
| EMF Training Services Ltd | Education | 2022 |
| EMH Chartered Accountancy Limited | Professional & scientific | 2025 |
| EMH Cheng Business Consultancy Ltd | Professional & scientific | 2011 |
| Emilora Ltd | Construction | 2026 |
| Emjay Fencing Limited | Construction | 2003 |
| Emlyn Owen Engineers Limited | Manufacturing | 1967 |
| Emma Sayers Hairdressing Ltd | Other services | 2014 |
| Emma Warnock-Parkes Ltd | Health & social care | 2021 |
| Emocean Ltd | Real estate | 2022 |
| Emocean Sailing Limited | Education | 2022 |
| Emphasis Training Limited | Professional & scientific | 1998 |
| Empire Catering Equipment Ltd | Wholesale & retail | 2025 |
| Empire Caviar Ltd | Hospitality | 2017 |
| Emrays Barbers Ltd | Other services | 2023 |
| EN Architects and Developments Limited | Professional & scientific | 2019 |
| Enabling Communications Limited | Information & communication | 2020 |
| Enartec Ltd | Administrative & support | 2012 |
| Enchanted Lands Limited | Arts & recreation | 2003 |
| Encoding Labs Ltd | Professional & scientific | 2026 |
| Encompass Build Ltd | Construction | 2025 |
| Encompass Developments Limited | Construction | 2025 |
| Encompass Estates Ltd | Real estate | 2025 |
| Encompass Homes Limited | Real estate | 2025 |
| Encompass Property Group Ltd | Construction | 2025 |
| Encounters Art Space Ltd | Education | 2021 |
| Encycarpedia Ltd | Information & communication | 2017 |
| Energize Events Limited | Arts & recreation | 2006 |
| Energy Locker Ltd | Construction | 2026 |
| Energy Parking Limited | Professional & scientific | 2023 |
| Energy Search Collective Limited | Administrative & support | 2015 |
| Energy Shield Group Ltd | Administrative & support | 2024 |
| Energy Shield SPV 1 Ltd | Extraterritorial | 2024 |
| Energy VIM Power Ltd | Professional & scientific | 2019 |
| Energy Wellness Ltd | Other services | 2021 |
| Engage Health Group Ltd | Financial services | 2016 |
| Engage Wealth Management Limited | Financial services | 2020 |
| Engfocus Limited | Information & communication | 2006 |
| English Business Park Management Limited | Real estate | 2002 |
| English in Chester Limited | Education | 1985 |
| Enhance Group (UK) Limited | Financial services | 2014 |
| Enigma Hospitality Ltd | Hospitality | 2025 |
| Enkeldorn Properties Limited | Real estate | 2009 |
| ENN Wholesale Ltd | Wholesale & retail | 2011 |
| Enqode Limited | Information & communication | 2022 |
| Enrg Electrical Group Ltd | Construction | 2025 |
| Enrg Limited | Information & communication | 2019 |
| ENT Consultant Care Limited | Health & social care | 2017 |
| Enteres Limited | Information & communication | 2025 |
| Enthuse Television & Events Limited | Arts & recreation | 2010 |
| Entrepreneur & Business Performance Coaching LLP | | 2009 |
| Environmental Compliance Specialists Limited | Professional & scientific | 2022 |
| Envision Corporation Limited | Real estate | 2011 |
| Envy Designs MAS Band Ltd | Hospitality | 2025 |
| Eott Community Interest Company | Information & communication | 2026 |
| EPC Brighton LLP | | 2008 |
| Epiphany Content Ltd | Other services | 2018 |
| EPM Entertainment Limited | Arts & recreation | 2025 |
| Eqld Limited | Professional & scientific | 2023 |
| Equilibrium Building Solutions Limited | Construction | 2010 |
| Equity Property Rentals Limited | Real estate | 2021 |
| ERC Global Ltd | Wholesale & retail | 2021 |
| Ereqi Construction Limited | Construction | 2020 |
| Erfroude Properties Ltd | Real estate | 2021 |
| Erris Building Contractors Limited | Construction | 2004 |
| Erudite Evolution Limited | Professional & scientific | 2013 |
| Erudite Holdings Limited | Financial services | 2017 |
| Erva Grill Limited | Hospitality | 2019 |
| Ervam Ltd | Hospitality | 2025 |
| ESC Software Limited | Information & communication | 2011 |
| Escape Hatch Media Recruitment Limited | Administrative & support | 2005 |
| Esde Ltd | Education | 2019 |
| Esigma Solutions Limited | Professional & scientific | 2014 |
| ESK39 Ltd | Real estate | 2023 |