| Esmail Medical Limited | Health & social care | 2020 |
| Esmail Property Limited | Real estate | 2021 |
| Esme Mckay Illustration Limited | Professional & scientific | 2021 |
| Esprit Consulting Ltd | Professional & scientific | 2025 |
| Esquisite Care UK Ltd | Other services | 2014 |
| Essemble Limited | Information & communication | 2013 |
| Essen Global Advisory Limited | Professional & scientific | 2025 |
| Essence Construction Ltd | Construction | 2024 |
| Essence Renovation Ltd | Construction | 2025 |
| Essency Locums Limited | Professional & scientific | 2020 |
| Essential Heating Engineers Limited | Construction | 2014 |
| Essential Works Architects Ltd | Professional & scientific | 2024 |
| Essentiel Ltd | Wholesale & retail | 2024 |
| Estate Management Limited | Real estate | 1993 |
| Estatecourt Limited | Construction | 1985 |
| Esto Search Limited | Administrative & support | 2023 |
| ET Drive Ltd | Wholesale & retail | 2023 |
| ET Drive Trade Ltd | Wholesale & retail | 2024 |
| Etch Restaurants Ltd | Hospitality | 2016 |
| Ethereal Flow Kids Ltd | Other services | 2026 |
| Ethereal Flow Studios Ltd | Other services | 2025 |
| Ethical Donut Ltd | Wholesale & retail | 2019 |
| Ethical Sourcing & Sustainable Agri Contractors(Essac) Ltd | Agriculture & fishing | 2025 |
| Ethometrix Ltd | Administrative & support | 2013 |
| Etica Advisory Limited | Professional & scientific | 2021 |
| Etnico Limited | Wholesale & retail | 1998 |
| ETR Consulting Limited | Professional & scientific | 2024 |
| EU Chinese Travel Ltd | Administrative & support | 2013 |
| Eubios Research International Ltd | Health & social care | 2019 |
| Eudoxia Limited | Construction | 2020 |
| Eugenius Leisure Limited | Professional & scientific | 1999 |
| Eunomia Ltd | Information & communication | 2026 |
| Euraman Limited | Other services | 1989 |
| Euro Smile Limited | Health & social care | 2012 |
| Euro-Worldwide Media Limited | Information & communication | 1997 |
| Eurodiet Health Ltd | Professional & scientific | 2018 |
| European ATV Safety Institute | Education | 2004 |
| Eusebio Sport UK Limited | Wholesale & retail | 2026 |
| Euterprise Limited | Arts & recreation | 2020 |
| EV Bay Management Ltd | Administrative & support | 2025 |
| EVA Aesthetics Ltd | Health & social care | 2024 |
| EVE Poland Limited | Wholesale & retail | 2010 |
| Evenden Estates Limited | Real estate | 1987 |
| Event Ambulance Service Ltd | Health & social care | 2024 |
| Event Your Universe Limited | Arts & recreation | 2013 |
| Everest Miles Limited | Construction | 2001 |
| Everestmiles Contractors Limited | Construction | 2017 |
| Every Second Media Limited | Professional & scientific | 2021 |
| Everyday Tasty Ltd | Hospitality | 2023 |
| Everything for Eczema Limited | Manufacturing | 2010 |
| Evolu Group Ltd | Professional & scientific | 2015 |
| Evolution Tutors Limited | Education | 2023 |
| Evolve Elevators Limited | Construction | 2024 |
| EW Agency Limited | Other services | 2011 |
| Excellent Traders Limited | Hospitality | 2014 |
| Exhibit Printing Limited | Administrative & support | 2009 |
| Existential Space Hove Ltd | Health & social care | 2024 |
| Exit Five Limited | Other services | 2009 |
| Exo-Gym Limited | Arts & recreation | 2020 |
| Exolite Limited | Professional & scientific | 2013 |
| Expedition UP Ltd | Information & communication | 2025 |
| Expert Lighting Ltd. | Wholesale & retail | 2011 |
| Expertly Simple Limited | Professional & scientific | 2010 |
| Experts in Skin & Hair Ltd | Health & social care | 2022 |
| Exploit Technology Solutions Ltd | Information & communication | 2014 |
| Exploration Consulting Services Ltd | Administrative & support | 2021 |
| Express & Chicken Ltd | Hospitality | 2025 |
| Expresslube (UK) Limited | Manufacturing | 2002 |
| Extra Food & Wine Store Ltd | Wholesale & retail | 2019 |
| Eye-D Technology Limited | Information & communication | 2007 |
| Eyeful Management Ltd | Professional & scientific | 2025 |
| Eyna Property Ltd | Real estate | 2026 |
| F & M Homes Ltd | Real estate | 2023 |
| F Simons (Imports) Limited | Transport & logistics | 2005 |
| F.C.Shepherd & Co. Limited | Wholesale & retail | 1965 |
| F.H.A. Properties Limited | Real estate | 1986 |
| F10 Studios Limited | Professional & scientific | 2008 |
| F90 Ltd | Other services | 2011 |
| FA Dental Limited | Health & social care | 2019 |
| FAB Films Limited | Information & communication | 2003 |
| FAB Health Care Agency Limited | Health & social care | 2024 |
| Fablovren Ltd | Transport & logistics | 2026 |
| Fabpad Investments Limited | Real estate | 2017 |
| Fabpad Property Ltd | Real estate | 2023 |
| Face Studio Official Ltd | Other services | 2025 |
| Faciendo Limited | Arts & recreation | 2000 |
| Factory Films Ltd | Information & communication | 2012 |
| Factotum Development Limited | Information & communication | 1996 |
| Facturama Limited | Information & communication | 2013 |
| Fahm Music Ltd | Information & communication | 2025 |
| Fair Consultancy Group Ltd | Hospitality | 2019 |
| Fair Price Care Ltd | Professional & scientific | 2016 |
| Fairdeal Domestic Appliances Ltd | Wholesale & retail | 2024 |
| Fairer Housing Brighton Limited | Real estate | 2023 |
| Fairfields Properties Limited | Real estate | 1955 |
| Fairhazel Ltd | Real estate | 2022 |
| Fairlan Roofing Ltd | Construction | 2019 |
| Fairstone Living Limited | Real estate | 2025 |
| Fairstone Property Holdings Limited | Real estate | 2017 |
| Fairstone Property Ltd | Real estate | 2015 |