| Dragon Property Developments Ltd | Real estate | 2020 |
| Dragon Property Maintenance Limited | Construction | 2021 |
| Dragon Silk Road Ltd | Wholesale & retail | 2026 |
| Dragone & Co Ltd | Professional & scientific | 2025 |
| Drama by the Sea Ltd | Education | 2025 |
| Dream Cassette Studios Ltd | Information & communication | 2025 |
| Dreamstart Ltd | Wholesale & retail | 2024 |
| Drebbond Limited | Extraterritorial | 2018 |
| Dress Like a MUM Limited | Wholesale & retail | 2015 |
| Driefontein Properties Limited | Real estate | 2009 |
| Drift Sleepwear Limited | Wholesale & retail | 2020 |
| Drillingco Ltd | Construction | 2023 |
| Drink Next Time Ltd | Information & communication | 2024 |
| Drinkbreak Ltd | Health & social care | 2025 |
| Driver Dan's Story Train Limited | Information & communication | 2011 |
| Drkohn Limited | Professional & scientific | 2025 |
| DRL Marketing Ltd | Information & communication | 2023 |
| Drone Roof Survey's and Security Observations Ltd | Professional & scientific | 2024 |
| DRP Pros Limited | Health & social care | 2023 |
| DRS Property Investments Ltd | Real estate | 2015 |
| Drsp Healthcare Limited | Health & social care | 2023 |
| Drumstick Tree Limited | Arts & recreation | 2020 |
| Drunken Buddha UN Limited | Information & communication | 2024 |
| DSN Supplies Ltd | Wholesale & retail | 2019 |
| DST Plumbing and Heating Ltd | Construction | 2022 |
| DT Comms Ltd | Information & communication | 2016 |
| Dtrmd Ltd | Hospitality | 2023 |
| Dubarry Residents RTM Company Limited | Households | 2025 |
| Ducemus Consulting Ltd | Professional & scientific | 2026 |
| Duckpin Limited | Extraterritorial | 2019 |
| Duffield Medical Ltd | Health & social care | 2025 |
| Dugard CNC Limited | Manufacturing | 2025 |
| Dukesbury House RTM Company Limited | Households | 2010 |
| Dunblair Court Limited | Households | 1998 |
| Duncan Insurance & Mortgage Services Ltd | Financial services | 2002 |
| Dunkeswell G1 Solar Farm Limited | Energy | 2014 |
| Dunwich RTM Company Limited | Real estate | 2024 |
| Dunya Productions Ltd | Information & communication | 2023 |
| Dunya Villas Ltd | Real estate | 2024 |
| Durfer Ltd | Hospitality | 2024 |
| Durham Lodge Hove Limited | Households | 2015 |
| Durrani Motors Limited | Wholesale & retail | 2025 |
| Dust Network Limited | Information & communication | 2021 |
| Dusted Design Ltd | Professional & scientific | 2007 |
| Dustless Ltd | Manufacturing | 2024 |
| Dutti Frutti Ltd | Manufacturing | 2021 |
| DWG Plans Sussex Ltd | Professional & scientific | 2025 |
| Dwsuk Ltd | Wholesale & retail | 2026 |
| Dwyersmith Ltd | Financial services | 2020 |
| Dyke Park Tennis Club CIC | Arts & recreation | 2020 |
| Dynaikon Ltd | Information & communication | 2015 |
| Dynamic Flooring Limited | Construction | 2016 |
| Dynamique Audio Ltd | Manufacturing | 2009 |
| DZ Motorcycles Limited | Wholesale & retail | 2023 |
| E S Dental Associate Limited | Health & social care | 2021 |
| E&B Collective Ltd | Hospitality | 2026 |
| E&E Medical Supplies Ltd | Wholesale & retail | 2016 |
| E&K Dental Limited | Health & social care | 2024 |
| E-Digital Design Limited | Information & communication | 2005 |
| E-Vendere Ltd | Professional & scientific | 2019 |
| E. Herandi Property Management Limited | Real estate | 2006 |
| E.L.S Electrics Ltd | Construction | 2017 |
| E.T. James Limited | Construction | 2008 |
| E15BD Properties Ltd | Extraterritorial | 2025 |
| E3 Live Ltd | Administrative & support | 2025 |
| E39 Hospitality Ltd | Hospitality | 2025 |
| Each Peach Childcare Ltd | Education | 2012 |
| EAG Developments Limited | Construction | 2021 |
| Eager Eyes Limited | Information & communication | 2006 |
| Eagle and Wicker VG Ltd | Construction | 2025 |
| Eagle and Wicker VG Rentals Ltd | Real estate | 2026 |
| Eagle Hydraulic Systems Limited | Manufacturing | 1988 |
| Eagle OWL Property Limited | Real estate | 2016 |
| Eagle Show Limited | Arts & recreation | 2025 |
| Earl of Sandwich (Brandco) Ltd. | Hospitality | 2000 |
| Earl of Sandwich (Licenseco) Limited | Hospitality | 1999 |
| Early Education Alliance Ltd | Education | 2012 |
| Early Explorers PRE School Limited | Health & social care | 2015 |
| Early Years Discovery Ltd | Education | 2018 |
| Earthward Bound Ltd. | Extraterritorial | 2020 |
| East Mews Dental Practice Limited | Administrative & support | 2010 |
| East Sussex Electrical Services Limited | Construction | 2023 |
| East Sussex Renewables Ltd | Construction | 2026 |
| East Tiger Trading Company Limited | Information & communication | 2021 |
| Eastbourne Student Lets Ltd | Real estate | 2015 |
| Eastbridge Shipping Ltd | Transport & logistics | 2021 |
| Eastbrook Properties Limited | Construction | 1951 |
| Eastern Gate Limited | Real estate | 2020 |
| Eastfield House Forest Gate Management Limited | Real estate | 2024 |
| Eastflat Limited | Households | 1992 |
| Eastmere Carpentry and Building Contractors Limited | Construction | 2002 |
| Eastworth Chertsey Ltd | Real estate | 2023 |
| Eastworth Chertsey RT Ltd | Construction | 2026 |
| Easy Beesy Limited | Arts & recreation | 2011 |
| Easy TAN 2 Ltd | Other services | 2025 |
| Easypage Solutions Ltd | Administrative & support | 2023 |
| Easyprint Solutions Limited | Manufacturing | 2017 |
| Easytrack Developments Limited | Information & communication | 2015 |
| Eaton Court (Brighton) Limited | Professional & scientific | 2005 |
| Eaton Garden Mansions RTM Company Limited | Extraterritorial | 2023 |