| DIM 247 Ltd | Real estate | 2016 |
| DIM 365 Ltd | Administrative & support | 2014 |
| DIM South Ltd | Other services | 2015 |
| DIM West Ltd | Real estate | 2023 |
| Dimitria Jordan Ltd | Administrative & support | 2012 |
| Dinky DOO Diner Ltd | Hospitality | 2019 |
| Dionysos Drinks Ltd | Wholesale & retail | 2023 |
| Direct Construction Services (UK) Ltd | Construction | 2012 |
| Direct Optical Limited | Administrative & support | 2015 |
| Direct Window Cleaning Ltd | Administrative & support | 2024 |
| Directa Design Ltd | Arts & recreation | 2022 |
| Dirty B Vape Limited | Wholesale & retail | 2018 |
| Dirty Bear Bones Limited | Hospitality | 2026 |
| Discover Brighton Limited | Professional & scientific | 2022 |
| Discover Golf Ltd | Administrative & support | 2024 |
| Discoverage Limited | Health & social care | 2024 |
| Distance Fields Ltd | Information & communication | 2021 |
| Distant Star Ltd | Information & communication | 2023 |
| District Three Ltd | Wholesale & retail | 2025 |
| Ditchling Court RTM Company Limited | Households | 2011 |
| Ditchling Property Company | Real estate | 1957 |
| Ditek Consultants Limited | Professional & scientific | 2014 |
| Diva Nails Ltd | Other services | 2025 |
| Divino Wine Bar Lounge Club Ltd | Hospitality | 2022 |
| Divisio Europe Limited | Transport & logistics | 2021 |
| Dixon Hurst Kemp Limited | Construction | 1997 |
| Dixon Hurst Limited | Construction | 2015 |
| Dixon Hurst Partnership Limited | Extraterritorial | 2024 |
| DIY Earth Ltd | Professional & scientific | 2024 |
| Diyke Ltd | Construction | 2024 |
| Djaj Dental Limited | Health & social care | 2021 |
| DJF Building Solutions Limited | Construction | 2019 |
| DJH Advertising Limited | Professional & scientific | 2009 |
| Djlivelle Ltd | Professional & scientific | 2019 |
| DJM Town Planning Limited | Professional & scientific | 2025 |
| DK Music Business Academy Ltd | Education | 2021 |
| DK33 Limited | Manufacturing | 1949 |
| DKM Electrical Services Limited | Construction | 2025 |
| DLB Trades Limited | Health & social care | 2025 |
| Dlic Limited | Professional & scientific | 2019 |
| DM Golf Ltd | Wholesale & retail | 2024 |
| DN Roofing Services Limited | Construction | 2010 |
| DNA Accounts Ltd | Professional & scientific | 2014 |
| DNA Property Partners Limited | Real estate | 2003 |
| DO Good. Well. Ltd | Professional & scientific | 2022 |
| Docklands Dental House Limited | Health & social care | 2018 |
| Doctor Content Ltd | Information & communication | 2022 |
| Dodd & COW Ltd | Real estate | 2009 |
| Dog & Duck Woodwork Ltd | Manufacturing | 2017 |
| Dogan Property Management Ltd | Real estate | 2022 |
| Doherty Brickwork Ltd | Construction | 2024 |
| Dolcemente Limited | Extraterritorial | 2018 |
| Dollop Creative Limited | Professional & scientific | 2023 |
| Dolls Mgmt Ltd | Arts & recreation | 2020 |
| Dolphin Computer Upgrades Limited | Information & communication | 2004 |
| Dolphin Court Owners RTM Company Limited | Households | 2020 |
| Dolphin Court VG Limited | Construction | 2025 |
| Dolphins Pre-School Limited | Education | 2010 |
| Domdedom Ltd | Information & communication | 2024 |
| Domestifi Ltd | Construction | 2026 |
| Dominic Ferris Music Ltd | Information & communication | 2014 |
| Dominion of Drama Ltd | Arts & recreation | 2020 |
| Don'T Just Coach Ltd | Education | 2020 |
| Donabie Associates Limited | Professional & scientific | 2012 |
| Donnaway Limited | Professional & scientific | 2024 |
| Donya Foods Ltd | Wholesale & retail | 2023 |
| Don’T Mention IT Ltd | Information & communication | 2025 |
| Dooner Glide Ltd | Wholesale & retail | 2018 |
| Doopey Designs Limited | Arts & recreation | 2014 |
| Door Nine Ltd | Professional & scientific | 2019 |
| Dorcom Rentals Limited | Other services | 2004 |
| Dosa Kngdom Resturant Ltd | Hospitality | 2024 |
| Dotcom Software Ltd | Information & communication | 2023 |
| Double Shake Limited | Hospitality | 2018 |
| Double Shot Films Limited | Information & communication | 2023 |
| Douedari Limited | Health & social care | 2023 |
| Dove GN Limited | Hospitality | 2010 |
| Dove View Solar Farm Limited | Energy | 2014 |
| Doveley's Court Freehold Ltd. | Households | 2008 |
| Doveley's Court Management Limited | Households | 1988 |
| Down to Ground Ltd | Wholesale & retail | 2021 |
| Downie (Hove) Limited | Construction | 2014 |
| Downin One Limited | Extraterritorial | 2004 |
| Dowse Design Ltd | Wholesale & retail | 2024 |
| Doyenne Creative Limited | Other services | 2018 |
| DPM Training Limited | Professional & scientific | 2002 |
| DPN Merchant Limited | Administrative & support | 2022 |
| DR Anand Dermatology Limited | Health & social care | 2021 |
| DR C a Ltd | Health & social care | 2016 |
| DR Heff's Limited | Health & social care | 2014 |
| DR Howie Limited | Health & social care | 2022 |
| DR Mark Austin Limited | Health & social care | 2019 |
| DR N C Gaut Ltd | Professional & scientific | 2021 |
| DR O’Hara Aesthetics Ltd | Health & social care | 2025 |
| DR Poppy Limited | Health & social care | 2022 |
| DR Rkmj and KJ Elite Dental Limited | Health & social care | 2021 |
| DR Ruta Ltd | Health & social care | 2009 |
| DR Sandelson Psychotherapy Limited | Health & social care | 2024 |
| DR Taijas Aesthetics Limited | Health & social care | 2020 |
| Dragbus Limited | Information & communication | 2024 |