| Sample Logistics Limited | Transport & logistics | 2005 |
| Samuels Corporate Limited | Professional & scientific | 1998 |
| Sandhawalia Development Ltd | Real estate | 2025 |
| Sandpit Gill Ltd | Other services | 2014 |
| Sandy Meadow Farm Campsite Ltd | Other services | 2020 |
| Sane Crested Limited | Health & social care | 2022 |
| Santiago PD Ltd | Arts & recreation | 2019 |
| Sapaudia Consulting Ltd | Professional & scientific | 2020 |
| Sarah Mackay Consultancy Ltd | Professional & scientific | 2024 |
| Sarah PYE Limited | Professional & scientific | 2004 |
| Sarah Shepherd Consulting Ltd | Professional & scientific | 2025 |
| Sarah Tulip Limited | Professional & scientific | 2011 |
| Saranayde Limited | Arts & recreation | 2006 |
| Sarasacchetti Limited | Professional & scientific | 2014 |
| Saravia Training Ltd | Professional & scientific | 2026 |
| Sarp IP Holdings Ltd | Administrative & support | 2024 |
| Sartest Limited | Professional & scientific | 1997 |
| SAS One Limited | Real estate | 2022 |
| Sassy & Lolla Ltd | Wholesale & retail | 2021 |
| Satellite Evolution Limited | Extraterritorial | 2021 |
| Save and Continue Ltd | Professional & scientific | 2022 |
| Save Education Ltd | Education | 2025 |
| Savory Financial Services Ltd | Financial services | 2018 |
| Savoy Music Ltd | Information & communication | 2025 |
| Saxon Down Ltd | Information & communication | 2007 |
| Saxon Farm Farriery Limited | Other services | 2017 |
| Saxon Weald Capital PLC | Financial services | 2012 |
| Sayansi Healthcare Limited | Professional & scientific | 2018 |
| Sayers & MAY Ltd | Professional & scientific | 2019 |
| SB Consulting (Horsham) Limited | Professional & scientific | 2024 |
| SB Leisure Gaming Ltd | Administrative & support | 2019 |
| SB Liesure Group Ltd | Professional & scientific | 2023 |
| SB Sports Media Limited | Information & communication | 2013 |
| SBI Systems Limited | Transport & logistics | 2012 |
| SC Performance Cars Ltd | Wholesale & retail | 2014 |
| Scanasign Limited | Extraterritorial | 2024 |
| SCD People Solutions Ltd | Administrative & support | 2019 |
| Scene Grand Prix Limited | Arts & recreation | 1995 |
| SCG Brand and Marketing Consulting Limited | Professional & scientific | 2018 |
| Scholars Lodge Residents Management Company Limited | Households | 2014 |
| Schroders Investment Portfolio Services Limited | Financial services | 2002 |
| Schulenberg Farms Limited | Agriculture & fishing | 1983 |
| Schumacher Law Ltd | Professional & scientific | 2020 |
| Sclola Ltd | Professional & scientific | 2023 |
| Scotblock Aviation Consulting Ltd | Professional & scientific | 2026 |
| Scotts Signs and Posters Ltd | Manufacturing | 2015 |
| Scrapline Limited | Construction | 1980 |
| Screen Social Group Limited | Professional & scientific | 2025 |
| Screen Social Limited | Professional & scientific | 2016 |
| Scribe Creative Ltd | Professional & scientific | 2021 |
| Scriven Enterprises Limited | Construction | 2025 |
| Scriven Industries Limited | Agriculture & fishing | 2019 |
| Scrypt Ltd | Financial services | 2020 |
| Sea Change AI Ltd | Information & communication | 2025 |
| Sea Change Ltd | Professional & scientific | 2025 |
| Seadrift Consulting Co Ltd | Administrative & support | 2026 |
| Seaford Sussex Catering Ltd | Hospitality | 2024 |
| Seafresh Enterprises Ltd | Administrative & support | 2022 |
| Seagraves Ltd | Financial services | 2024 |
| Seagreens Harvesting Systems Ltd | Agriculture & fishing | 2020 |
| Seagreens International Partnership Trustees Ltd | Agriculture & fishing | 1989 |
| Seagreens Limited | Manufacturing | 1996 |
| Seagull Logistics London Ltd | Financial services | 2024 |
| Secrets of Slumber Ltd | Health & social care | 2023 |
| Secunis Managed Systems Ltd | Information & communication | 2025 |
| Seenthis Limited | Information & communication | 2002 |
| Segev Limited | Real estate | 2014 |
| Select Control Limited | Construction | 2009 |
| Select Travel Limited | Administrative & support | 1995 |
| Select-A-Home Limited | Extraterritorial | 1986 |
| Selumi Investments Limited | Financial services | 2023 |
| Semper Learning Ltd | Professional & scientific | 2015 |
| Semproto Ltd | Information & communication | 2016 |
| Sendero Solutions Ltd | Information & communication | 2023 |
| Sense Check Limited | Professional & scientific | 2017 |
| Sense Media Group Ltd | Administrative & support | 2015 |
| Sense Media Holdings Ltd | Administrative & support | 2022 |
| Sensemaking Consulting Limited | Professional & scientific | 2016 |
| Sentinel IT Services Limited | Information & communication | 2021 |
| Seofon Business Services Limited | Professional & scientific | 2012 |
| Separate Star Productions CIC | Education | 2018 |
| Septech Services Ltd | Construction | 2024 |
| Serafini Limited | Financial services | 2025 |
| Serendiva Limited | Wholesale & retail | 2025 |
| Service Trades Ltd | Professional & scientific | 2025 |
| Services Depot Ltd | Administrative & support | 2014 |
| Servicex AI Limited | Information & communication | 2025 |
| SES Care & Consultancy Limited | Real estate | 1999 |
| Setfords Consultants Ltd | Construction | 2017 |
| SEV7EN Ltd | Wholesale & retail | 2025 |
| Seventh Green Limited | Professional & scientific | 2020 |
| Sexton Engineering Limited | Manufacturing | 2016 |
| Seymour Holdings 47 Ltd | Real estate | 2018 |
| SFD Consulting Ltd | Professional & scientific | 2022 |
| SFS Facilities Ltd. | Administrative & support | 2017 |
| Sghg Ltd | Professional & scientific | 2023 |
| SGM Logistics Ltd | Transport & logistics | 2023 |
| SGR Sales Limited | Wholesale & retail | 2002 |
| SGS Surfacing Limited | Construction | 2014 |
| SH Block Management Company Limited | Households | 2025 |