| Collinson Watkinson Developments Limited | Construction | 2003 |
| Colour Tone Masterbatch Limited | Manufacturing | 1996 |
| Colplan Limited | Manufacturing | 1994 |
| Connect My Claim Ltd | Professional & scientific | 2024 |
| Connect Norton Media Ltd | Professional & scientific | 2020 |
| Connectis Limited | Professional & scientific | 2002 |
| Conscious Music Limited | Information & communication | 2012 |
| Consera Relationship Wellness Ltd | Administrative & support | 2021 |
| Consera Training Limited | Education | 2023 |
| Construo Ltd | Information & communication | 2018 |
| Contego Animal Health Ltd | Wholesale & retail | 2021 |
| Content Capture Services Limited | Manufacturing | 1997 |
| Contractfs Ltd | Wholesale & retail | 2011 |
| Coombe Capital Limited | Financial services | 2017 |
| Corcoran Accounting Limited | Professional & scientific | 2024 |
| Corkickle Breaks Ltd | Hospitality | 2022 |
| Cornerstone Kitchens & Bathrooms Ltd | Wholesale & retail | 2026 |
| Cornerstones Joinery and Construction Limited | Construction | 2024 |
| Corroded Creations Ltd | Wholesale & retail | 2025 |
| Cosmo (NW) Limited | Hospitality | 2018 |
| Countrylife Ltd | Manufacturing | 2023 |
| County Drains Limited | Other services | 2002 |
| Coverley Holdings Limited | Financial services | 2026 |
| Covwich Limited | Real estate | 2019 |
| Cracken Edge Limited | Real estate | 2022 |
| Cracken Place Holdings Limited | Financial services | 2019 |
| Craig Goddard Haulage Limited | Transport & logistics | 2016 |
| Craven Lettings Limited | Real estate | 2026 |
| Creata Plate Ltd | Wholesale & retail | 2023 |
| Creon UK Limited | Professional & scientific | 2021 |
| Crispy COD (New Mills) Limited | Hospitality | 2011 |
| Cross Section Equestrian Limited | Wholesale & retail | 2024 |
| Crown Scaffolding (UK) Ltd | Construction | 2014 |
| Crowstone Limited | Professional & scientific | 2010 |
| CSB Consulting (Manchester) Ltd | Professional & scientific | 2018 |
| CSV Developments Ltd | Real estate | 2015 |
| CTH Groundwork and Excavation Limited | Construction | 2023 |
| Currie Jones Associates Limited | Arts & recreation | 1992 |
| Curtain Collect Limited | Wholesale & retail | 2017 |
| CW Project Control Services Ltd | Professional & scientific | 2018 |
| Cycle Britain Ltd | Arts & recreation | 2003 |
| Cycle Space Bikes Ltd | Wholesale & retail | 2016 |
| Cylon Enterprise Ltd | Wholesale & retail | 2023 |
| D & L Consultants Limited | Professional & scientific | 2013 |
| D Fairhurst Plumbing & Heating Limited | Construction | 2017 |
| D G E Lomas Ltd | Professional & scientific | 2013 |
| D J Engineering Exports Ltd | Manufacturing | 2022 |
| D R Hadfield Haulage Ltd | Transport & logistics | 2022 |
| D R Hague Property's Ltd | Real estate | 2026 |
| D Turnbull Consulting Ltd | Professional & scientific | 2014 |
| D.H. & B.A. Wellburn Limited | Wholesale & retail | 1987 |
| DAE Design Limited | Professional & scientific | 2007 |
| Daily Access Ltd | Construction | 2025 |
| Dalwhinnie Bloodstock Ltd | Arts & recreation | 2014 |
| DAN Fone Web Development Ltd | Information & communication | 2018 |
| Danatek Limited | Other services | 2009 |
| Daniels-Payne Ltd | Hospitality | 2022 |
| Dark Grove Enterprises Ltd | Hospitality | 2024 |
| Dark Peak Properties Limited | Real estate | 2025 |
| Darryl Hall Building and Plastering Contractors Ltd | Construction | 2016 |
| Datamade Ltd | Arts & recreation | 2019 |
| Datatune Ltd | Information & communication | 2025 |
| Datum Core Management Limited | Construction | 2021 |
| Dave Bloor Heating and Plumbing Services Ltd | Construction | 2023 |
| David Arnold Opticians Limited | Health & social care | 1996 |
| Dcms Consultants Limited | Professional & scientific | 2008 |
| Dead Door Production Limited | Transport & logistics | 2014 |
| Deaville Estates Ltd | Hospitality | 2023 |
| Debcare Limited | Other services | 2012 |
| Deltamount Limited | Professional & scientific | 1985 |
| Dennis Tilley Machine Tools Limited | Manufacturing | 1995 |
| Derbyshire Stock Fencing Limited | Construction | 2011 |
| DES Coleman Butchery Services Limited | Wholesale & retail | 2019 |
| DES Powder Coating Ltd | Manufacturing | 2021 |
| Deslandes Access Limited | Construction | 2015 |
| Desmond Enterprises Ltd | Wholesale & retail | 2018 |
| Desotec UK Limited | Professional & scientific | 2022 |
| Detail LAB Products Ltd | Wholesale & retail | 2025 |
| Devonshire Consultancy Limited | Professional & scientific | 2001 |
| Dfdsupplies Ltd | Wholesale & retail | 2025 |
| Dialmode (335) Limited | Professional & scientific | 2006 |
| Dickson Wharf Owners Limited | Real estate | 2016 |
| Dilworth & Morris (Engineers Merchants) Limited | Wholesale & retail | 1990 |
| Dilworth & Morris Residential Properties Limited | Real estate | 2005 |
| Dingle Properties Limited | Real estate | 2022 |
| Disaster AID International | Extraterritorial | 2018 |
| Disaster AID UK & Ireland | Other services | 2003 |
| DJ Driving Limited | Transport & logistics | 2025 |
| DJ Sidebottom Ltd | Agriculture & fishing | 2019 |
| DJH Associates Ltd | Professional & scientific | 2014 |
| Djo-I Limited | Real estate | 2024 |
| Djwstats Consulting Ltd | Professional & scientific | 2018 |
| DMC Distribution Limited | Transport & logistics | 2007 |
| Dog & Dome Ltd | Wholesale & retail | 2019 |
| Don'T Break IT Ltd | Hospitality | 2020 |
| Donaghue Electrical Solutions Ltd | Construction | 2023 |
| Dont Panic Accountancy Limited | Professional & scientific | 2018 |
| Douglas & KIN Ltd | Other services | 2023 |
| Douglas-Mullett Holdings Limited | Real estate | 2015 |
| DR Isabelle Shone Ltd | Health & social care | 2025 |