| DR K Wiseman Limited | Health & social care | 2025 |
| Dragon Opal Consulting Ltd | Professional & scientific | 2012 |
| Drain Master 247 Ltd | Construction | 2025 |
| Drain Right Ltd | Construction | 2021 |
| Drayson Building Limited | Real estate | 2002 |
| Drum and Monkey (High Peak) Limited | Administrative & support | 2012 |
| DS One Home Limited | Real estate | 2022 |
| DSP Building Services Consulting Engineers Limited | Professional & scientific | 2009 |
| Duca Homes Ltd | Hospitality | 2025 |
| Dunne Brothers Limited | Real estate | 2020 |
| Durkin Design Services Limited | Professional & scientific | 2013 |
| DW Claim Solutions Limited | Information & communication | 2023 |
| Dynamic Doodles Ltd | Information & communication | 2017 |
| Dyslexia and Neurodiversity In-Sight Ltd | Education | 2020 |
| E-Logica Ltd | Health & social care | 2010 |
| E.Bielesz.Property Ltd | Real estate | 2023 |
| E2E4 (2008) Limited | Information & communication | 2020 |
| EA North West Limited | Wholesale & retail | 2025 |
| Eadon Property Limited | Real estate | 2013 |
| Earthmove UK Ltd | Transport & logistics | 2024 |
| Eastmond Medicomm Limited | Professional & scientific | 2010 |
| Easy Granite Ltd | Manufacturing | 2020 |
| Eaves (North) Ltd | Construction | 2019 |
| Eaves Barn Ltd | Professional & scientific | 2024 |
| EB Financial Services Limited | Professional & scientific | 2007 |
| ECHO85 Ltd | Arts & recreation | 2025 |
| Eco Charge Ltd | Other services | 2019 |
| Edave Property Limited | Households | 2025 |
| Edelman Investments Limited | Real estate | 2017 |
| Edgbaston Healthcare Limited | Other services | 1997 |
| Edge Construction Services Ltd | Construction | 2021 |
| Edifice Building Consultants Limited | Professional & scientific | 2014 |
| Edkey Cinema Company Limited | Information & communication | 1977 |
| Effective Business Consulting Limited | Professional & scientific | 1998 |
| Elenya Limited | Professional & scientific | 2025 |
| Eliston Homes Limited | Construction | 2015 |
| Elite Coachworks Group Ltd | Financial services | 2021 |
| Elite Construction (NW) Ltd | Construction | 2016 |
| Elite Kitchens Bathrooms Plumbing & Heating NW Ltd | Construction | 2018 |
| Elleffsee Ltd | Professional & scientific | 2015 |
| ELM Wood Residential Limited | Real estate | 2026 |
| Elyrium Ltd | Information & communication | 2024 |
| EM Consultants Limited | Information & communication | 2001 |
| Emma's SVC Ltd | Hospitality | 2025 |
| END Game Properties Limited | Construction | 2025 |
| Energy Cell Treatment Limited | Health & social care | 2012 |
| Energy Equals Limited | Professional & scientific | 2019 |
| Engineers Page Ltd | Professional & scientific | 2023 |
| England China Trading Limited | Financial services | 2016 |
| Enriched Enterprises Ltd | Other services | 2013 |
| Entertainment Trade Management (Agencies) Limited | Administrative & support | 2004 |
| Entire Assets Limited | Financial services | 2020 |
| Entire Logic LLP | | 2015 |
| Enviro-Pp Ltd | Manufacturing | 2021 |
| Environ Construction Ltd | Financial services | 2023 |
| Environ Consultants Limited | Professional & scientific | 2008 |
| Environ DI Limited | Construction | 2021 |
| Environ Fabrications Ltd | Professional & scientific | 2023 |
| Environ Holdings Limited | Construction | 2016 |
| Environ Projects Limited | Professional & scientific | 2018 |
| Environ Skyworks Limited | Manufacturing | 2021 |
| Equality Homecare Services Limited | Other services | 2007 |
| Equestrian Arenas Limited | Agriculture & fishing | 2016 |
| ESE Project Management Limited | Professional & scientific | 1997 |
| Eskola Education Ltd | Education | 1999 |
| Evelane Home Limited | Real estate | 2026 |
| Evidence Based Rehabilitation Academy Ltd | Professional & scientific | 2023 |
| Evodevo Cycling C.I.C. | Arts & recreation | 2023 |
| Evolve Counselling Ltd | Professional & scientific | 2017 |
| Excelsior Accountants Limited | Professional & scientific | 2011 |
| Excuvia Ltd | Professional & scientific | 2025 |
| Eyisab Property Investments Limited | Real estate | 2021 |
| Fairfield Road (Buxton) Management Company Limited | Real estate | 2008 |
| Fairmeadows Services Limited | Agriculture & fishing | 2023 |
| Farmers & Friends Ltd | Professional & scientific | 2024 |
| Fast Track Aviation Limited | Information & communication | 2016 |
| Faye Legal Ltd | Professional & scientific | 2026 |
| Fence and Barrier Ltd | Construction | 2020 |
| FGC Resources Ltd | Professional & scientific | 2022 |
| Fiber Fabrics Ltd | Wholesale & retail | 2020 |
| Fightinfit Limited | Arts & recreation | 2005 |
| FIN & Game Retail Limited | Wholesale & retail | 2023 |
| Firmbid Limited | Real estate | 2010 |
| First Direct Developments Limited | Construction | 2009 |
| First ME Coaching Ltd | Health & social care | 2026 |
| First Steps Nursery (New Mills) Limited | Education | 2006 |
| Fish Films Ltd. | Information & communication | 1997 |
| Fit Gainz Ltd | Arts & recreation | 2019 |
| Fitness in Mind Ltd | Health & social care | 2023 |
| Fizz Chop Ltd | Hospitality | 2024 |
| Flamestar Consulting Limited | Professional & scientific | 2013 |
| Floormaster Paints Limited | Extraterritorial | 2000 |
| FLY on the Wall Press Ltd | Information & communication | 2024 |
| Focal Design Limited | Real estate | 1976 |
| Focal Mccormack Developments Ltd | Real estate | 1988 |
| Ford Freight Limited | Transport & logistics | 2009 |
| Ford Solutions NW Limited | Construction | 2025 |
| Forest Chapel Hives Limited | Wholesale & retail | 2024 |
| Foster Richardson Ltd | Real estate | 2025 |
| Founders Media Ltd | Professional & scientific | 2016 |