| Spenbase Limited | Real estate | 1997 |
| Sphere Accountants Ltd | Professional & scientific | 2020 |
| Sphere Financial Services Ltd | Professional & scientific | 2012 |
| Sphere FS Limited | Professional & scientific | 2012 |
| Spinka Collective Ltd | Wholesale & retail | 2019 |
| Sportimage Limited | Professional & scientific | 2018 |
| Spotless Cleaning (Cheshire) Ltd | Administrative & support | 2018 |
| Sprospark Electrical Ltd | Construction | 2026 |
| Squiffy Squirrel Inns Ltd | Hospitality | 2025 |
| SR Courier Services Ltd | Transport & logistics | 2016 |
| SSP Enterprises Limited | Other services | 2021 |
| Stadium Tourist Limited | Administrative & support | 2023 |
| Stafford Aviation Limited | Transport & logistics | 2009 |
| Stag Joinery Ltd | Construction | 2017 |
| Standout Marketing Services Ltd | Professional & scientific | 2022 |
| Stanway & Hallows Electrical Limited | Wholesale & retail | 2003 |
| Stanway Sales Ltd | Real estate | 1999 |
| Stanways Lighting & Heating Ltd | Wholesale & retail | 2002 |
| Star FS Ltd | Financial services | 2017 |
| Staten Studio Ltd | Professional & scientific | 2017 |
| Stationora Limited | Manufacturing | 2025 |
| Stevenson Deane Developments Limited | Construction | 2025 |
| Stevenson Deane Property Co Ltd. | Construction | 1993 |
| Stockdart Power Limited | Professional & scientific | 2012 |
| Stockport and High Peak Estates Ltd | Real estate | 2023 |
| Stockport Labour Party(Holdings)Limited | Hospitality | 1952 |
| Stockport Storage Limited | Transport & logistics | 2010 |
| Stodhart Mews Management Company Limited | Households | 2004 |
| Stoney Philbin & Company Limited | Professional & scientific | 2016 |
| Story First Films Ltd | Information & communication | 2019 |
| Storycraft Strategies Limited | Administrative & support | 2024 |
| Structured Wealth Management Limited | Financial services | 2015 |
| Suburban INK Limited | Other services | 2012 |
| SUE Street Development Ltd | Professional & scientific | 2022 |
| Sunshine Nursery School Limited | Education | 2006 |
| Super Seal Waterstop Ltd. | Administrative & support | 2018 |
| Suppher CIC | Hospitality | 2023 |
| Suppshub Ltd | Wholesale & retail | 2023 |
| Supreme Heating & Plumbing Ltd | Construction | 2021 |
| Susie Poppitt Consultancy Limited | Administrative & support | 2011 |
| Sutherland Reay & Co Limited | Real estate | 2010 |
| Swan Inn Kettleshulme Limited | Hospitality | 2015 |
| Sweet Sugar Candy Van Ltd | Hospitality | 2025 |
| Swift Fit Properties Ltd | Real estate | 2024 |
| Swift Plumbing & Heating Limited | Construction | 2002 |
| Synergen Limited | Construction | 2017 |
| Synthesiser Sounds Limited | Arts & recreation | 2023 |
| T Green & SON Builders Limited | Other services | 2016 |
| T Murray Limited | Construction | 2016 |
| T&Gpropertygroup Ltd | Real estate | 2025 |
| T. W. Marine Limited | Manufacturing | 1981 |
| T.O.P Gardens Limited | Administrative & support | 2016 |
| Talk to Franc Ltd | Manufacturing | 2022 |
| Tameside Carriage Masters Ltd | Other services | 2025 |
| Tangent Agency Limited | Professional & scientific | 2025 |
| Tangent Design Limited | Professional & scientific | 2000 |
| TAP GET Ltd | Information & communication | 2025 |
| Tarim Food Ltd | Hospitality | 2026 |
| TAS Training Associates Ltd | Administrative & support | 2003 |
| Tasha's Chakra Shed Ltd | Other services | 2023 |
| Taste World Ltd | Hospitality | 2023 |
| Taxal Limited | Administrative & support | 1998 |
| TEC Installations Ltd | Construction | 2018 |
| Technikos Digital Solutions Ltd | Information & communication | 2022 |
| Technoscopic Limited | Transport & logistics | 2019 |
| Teetering Rock Limited | Information & communication | 2009 |
| Telford Serviced Accommodation Ltd | Real estate | 2019 |
| Terpander Ltd | Information & communication | 2023 |
| Terra Care Ltd | Financial services | 2018 |
| Thames Yacht Hire Limited | Transport & logistics | 2015 |
| THE 3 Project Ltd | Health & social care | 2026 |
| THE Accessories Shop Ltd | Wholesale & retail | 2019 |
| THE Argentinian BBQ Ltd | Hospitality | 2022 |
| THE Asico Inn Limited | Hospitality | 2017 |
| THE Blind Bull Ltd | Hospitality | 2019 |
| THE Bridge Bakehouse Limited | Hospitality | 2025 |
| THE British Emotionally Focused Therapy Centre C.I.C. | Other services | 2024 |
| THE Carton Content Co. Ltd | Professional & scientific | 2026 |
| THE Cartonboard Company Limited | Wholesale & retail | 2017 |
| THE Cheshire Embalming Services Limited | Health & social care | 2022 |
| THE Contour Creator Ltd | Other services | 2024 |
| THE Cracken Ltd | Hospitality | 2024 |
| THE Devonshire Arms Management Company Limited | Households | 2013 |
| THE Fire Place New Mills Ltd | Wholesale & retail | 2026 |
| THE Fitting Store Ltd | Wholesale & retail | 2025 |
| THE Hartington Cheese & Wine Company Limited | Real estate | 2009 |
| THE J&S Group Ltd | Construction | 2018 |
| THE KID Company Day Nurseries Limited | Health & social care | 2020 |
| THE Lamb Inn (Asquith) Ltd | Hospitality | 2014 |
| THE Lantern Pike Inn Limited | Hospitality | 2016 |
| THE Large Company Limited | Real estate | 2022 |
| THE Little M Company Limited | Information & communication | 1997 |
| THE Little Mill Inn at Rowarth Ltd | Hospitality | 2025 |
| THE Old Photo Factory Ltd. | Arts & recreation | 2016 |
| THE People Partner HR & Training Ltd | Administrative & support | 2021 |
| THE Real ALE Cell House Limited | Hospitality | 2016 |
| THE Relief Greenkeeper (Cheshire) Ltd | Administrative & support | 2026 |
| THE Relief Greenkeeper Ltd | Administrative & support | 2025 |
| THE Rivet Media Limited | Information & communication | 2010 |
| THE Shuker Partnership Limited | Construction | 2023 |