| Richard James Joinery Ltd | Manufacturing | 2015 |
| Richard Peel Consultancy Ltd | Construction | 2013 |
| Richardson Renewable Energy Ltd | Energy | 2026 |
| Riding Home Farm Management Company Limited | Real estate | 2010 |
| Ridleys Fish and Game Limited | Manufacturing | 2012 |
| Rigel Aviation Limited | Manufacturing | 2015 |
| RIR (Farming & Vehicles) Limited | Financial services | 2017 |
| Rivendell Cars Limited | Wholesale & retail | 2022 |
| Riverdale Hall Hotel Ltd | Hospitality | 1999 |
| Riverdale NO.1. Partnership. | | 1993 |
| Riverdale Properties (Kielder) Limited | Hospitality | 2012 |
| Rivers Meet Productions Limited | Information & communication | 2019 |
| Riverside 2.0 Automotive Ltd | Wholesale & retail | 2025 |
| Riverside Operations Limited | Administrative & support | 1992 |
| Riverview Property (NE) Ltd | Real estate | 2024 |
| Roberts and Partners Ltd | Arts & recreation | 2007 |
| Robinson Landscape Design Limited | Professional & scientific | 2000 |
| Robson & Sons (Hexham) Limited | Wholesale & retail | 1982 |
| Robson Management Solutions Ltd | Professional & scientific | 2023 |
| Robson Print Limited | Manufacturing | 1998 |
| Robson Utilities Ltd | Construction | 2024 |
| Robson Walker (Northern) Limited | Real estate | 1976 |
| Rock Safely Limited | Extraterritorial | 2015 |
| Romigo Cleaning Ltd | Administrative & support | 2020 |
| Room to Play Limited | Wholesale & retail | 2020 |
| Roomserve Limited | Manufacturing | 1999 |
| Rough Luxe Designs Ltd | Manufacturing | 2012 |
| Routes of Happiness Ltd | Administrative & support | 2025 |
| Rowell Coaches Ltd | Transport & logistics | 2013 |
| RSK Enterprise Limited | Wholesale & retail | 2016 |
| Ruminant Revival Limited | Professional & scientific | 2025 |
| Ruth Carr Ltd | Professional & scientific | 2015 |
| S & D Timber Harvesting Ltd | Agriculture & fishing | 2013 |
| S Fairless Limited | Administrative & support | 2023 |
| S J Kerrigan Limited | Agriculture & fishing | 2017 |
| S R Building Services North East Limited | Construction | 2025 |
| S. Harrison Plumbing Limited | Construction | 2017 |
| S. J. Pigg Ltd | Manufacturing | 2020 |
| Safe & Secure 24 Monitoring Limited | Administrative & support | 2004 |
| Safe and Secure 24 ARC Limited | Administrative & support | 2009 |
| Saiph Watch Ltd | Households | 2021 |
| Sales Workforce Platform Limited | Information & communication | 2026 |
| Samepage Digital Limited | Information & communication | 2019 |
| Samespace Coworking Ltd | Real estate | 2021 |
| Samling Institute for Young Artists | Education | 2005 |
| Samuel Douglas Manufactured Joinery Ltd | Construction | 2026 |
| Sapmore Holdings Limited | Professional & scientific | 1999 |
| Sapphire Environmental Ltd. | Water & waste | 2010 |
| Sarah Dyer Heritage Ltd | Professional & scientific | 2019 |
| Sarah Hickey Jewellery Ltd | Manufacturing | 2015 |
| Satellite Films Limited | Information & communication | 2011 |
| Scrans NE Limited | Hospitality | 2018 |
| SD Gebbels Building Services Ltd | Construction | 2023 |
| SDJ Design Engineering Limited | Construction | 2008 |
| SDJ Innovate Limited | Professional & scientific | 2024 |
| SDV Consultancy Ltd | Real estate | 2022 |
| Seacroft Energy Ltd | Professional & scientific | 2023 |
| Seaground Ltd | Professional & scientific | 2020 |
| Sean Butler Consulting Limited | Professional & scientific | 2009 |
| SEE Through Window Cleaners Limited | Administrative & support | 2022 |
| Sellthemoon Ltd | Wholesale & retail | 2005 |
| Selr Holdings Ltd | Real estate | 2021 |
| Sendily Ltd | Professional & scientific | 2024 |
| Sendit.To Limited | Information & communication | 2005 |
| Sentry Boats Ltd | Professional & scientific | 2016 |
| Septieme Consultancy Ltd | Information & communication | 2016 |
| Serin Control & Automation Limited | Construction | 1999 |
| Settlingstones Services Ltd | Water & waste | 2012 |
| SEVEN360 Systems Limited | Information & communication | 2022 |
| Sezze Apartments Management Company Limited | Real estate | 2001 |
| SGS Timber Haulage Limited | Transport & logistics | 1998 |
| She's a Peach Limited | Professional & scientific | 2024 |
| Shotton Waste Services Limited | Extraterritorial | 2014 |
| SHR Excavations Ltd | Construction | 2019 |
| Shrimpton Properties Ltd | Hospitality | 2024 |
| Shutter&Soul Photography Ltd | Professional & scientific | 2025 |
| Silvermoor Limited | Manufacturing | 2005 |
| Simms Holdings Limited | Financial services | 2021 |
| Simonburn Flat Roofing & External Works Limited | Construction | 2025 |
| Sixbetween Limited | Information & communication | 2016 |
| SJ Bell Logistics Ltd | Transport & logistics | 2025 |
| Sky Tents Custom Canvas Ltd | Manufacturing | 2019 |
| Sky Tents Events Limited | Hospitality | 2021 |
| SM Hospitality Consultancy + Recruitment Ltd | Professional & scientific | 2024 |
| SM Procurement Services Ltd | Professional & scientific | 2013 |
| Smart G Limited | Hospitality | 2014 |
| Smart Start Careers Limited | Administrative & support | 2025 |
| Smart Yachts International Limited | Information & communication | 2019 |
| Smile Barbering Services Ltd | Other services | 2023 |
| Smms Ward Limited | Health & social care | 2024 |
| Sneak Preview E-Commerce Development Ltd | Information & communication | 2017 |
| SNJ Leisure (Northumberland) Ltd | Hospitality | 2024 |
| Solar Energy Parks Ltd | Other services | 2019 |
| Solarair.Me Ltd | Extraterritorial | 2012 |
| Soonerstill Limited | Households | 1989 |
| Sorella Marketing Limited | Wholesale & retail | 2003 |
| South Tyne Angling Association Limited | Arts & recreation | 2007 |
| Sparrow Self-Employed Carers Limited | Administrative & support | 2023 |
| Specialist Window Services Limited | Construction | 2009 |
| Spicebd Ltd | Hospitality | 2024 |