| Spinney Consultants Limited | Information & communication | 2015 |
| Spirit Beaver Ltd | Wholesale & retail | 2023 |
| Sports Car Supplies Limited | Wholesale & retail | 1995 |
| Sportsta Limited | Arts & recreation | 2023 |
| ST Luke’S Property Management Ltd | Hospitality | 2012 |
| ST. Mary's Chare Developments Limited | Real estate | 1972 |
| St.Mary's Nursery (Hexham) Limited | Education | 1999 |
| Stable Books Ltd | Professional & scientific | 2025 |
| Stage Fright C.I.C. | Health & social care | 2023 |
| Stakehold Studio Ltd | Professional & scientific | 2025 |
| Stanegate Services Ltd | Wholesale & retail | 2008 |
| Stanton Mortimer Limited | Real estate | 2005 |
| Star-Mic Ltd | Information & communication | 2026 |
| Start Recruitment Ltd | Administrative & support | 2022 |
| Stephen Bell Contracts Limited | Construction | 2023 |
| Sterna Ecology Ltd. | Professional & scientific | 2016 |
| Stewart Mackinnon Films Limited | Information & communication | 2006 |
| Stonedale Developments Ltd | Construction | 2021 |
| Stonedale Property Letting Limited | Real estate | 2021 |
| Stonehaugh Campsite Limited | Hospitality | 2021 |
| Stonehill Logisitcs Ltd | Transport & logistics | 2026 |
| Street Sauce Ltd | Hospitality | 2023 |
| Stride Career Coaching Ltd | Other services | 2022 |
| Strom Holdings UK Ltd | Wholesale & retail | 2017 |
| Structic Innovations Ltd | Professional & scientific | 2023 |
| Structic Ltd | Professional & scientific | 2018 |
| Struthers Films Limited | Information & communication | 2014 |
| STS Enterprises Limited | Hospitality | 2021 |
| Studio 18 (Newcastle) Limited | Professional & scientific | 2022 |
| Studio Dean Ltd | Professional & scientific | 2019 |
| Studio Koomen Ltd | Arts & recreation | 2023 |
| Studio Second Best Ltd | Administrative & support | 2016 |
| Studio Supplements Ltd | Wholesale & retail | 2006 |
| Stygg Limited | Hospitality | 2021 |
| Sumit Engineering Limited | Professional & scientific | 2025 |
| Sunrise Hope Limited | Hospitality | 2020 |
| Supa 9 Limited | Professional & scientific | 2002 |
| Susie Tate Projects CIC | Arts & recreation | 2021 |
| SV Auto and Machinery Ltd | Manufacturing | 2024 |
| Swansons of Hexham Limited | Construction | 2018 |
| Swayed Greyhound Limited | Administrative & support | 2007 |
| Syed Mannan Company Limited | Health & social care | 2023 |
| T.Charlton & Sons (Newbrough) Limited | Construction | 1950 |
| T.K.T.H. Limited | Hospitality | 2025 |
| T2 Spicery Ltd | Hospitality | 2025 |
| Tahuna Manuka Honey Ltd | Wholesale & retail | 2023 |
| Takeoff Live Ltd | Professional & scientific | 2013 |
| Taking Your Business Online Ltd | Information & communication | 2022 |
| Tame NE Limited | Professional & scientific | 2024 |
| Tarset 2050 Community Interest Company | Professional & scientific | 2007 |
| Tarset Property Company Limited | Professional & scientific | 2006 |
| Tarset TOR Ltd | Hospitality | 2014 |
| Tartlet Limited | Financial services | 2024 |
| TBA Heating & Plumbing Ltd | Construction | 2022 |
| TC Stokoe Rodger Limited | Professional & scientific | 2024 |
| TC Tree Services NE Ltd | Administrative & support | 2025 |
| Tech Events Ltd | Administrative & support | 2024 |
| Tercel Consulting Limited | Professional & scientific | 2013 |
| Terra Ligna Ltd | Manufacturing | 2019 |
| Terraligo Ltd | Manufacturing | 2023 |
| Tethra Energy Limited | Professional & scientific | 2013 |
| That Taxi Co Hexham Ltd | Transport & logistics | 2024 |
| THE Achievement Algorithm Ltd | Education | 2024 |
| THE Adventure Singles Ltd | Arts & recreation | 2026 |
| THE Bike Place in Kielder Ltd | Wholesale & retail | 2008 |
| THE Bike Place Ltd | Administrative & support | 2011 |
| THE Black Bull Bellingham Limited | Hospitality | 2021 |
| THE Bodywork Centre Limited | Administrative & support | 2017 |
| THE Border Reiver Ltd | Wholesale & retail | 2004 |
| THE Brierley Collective Limited | Real estate | 2025 |
| THE Cashflow Resource Limited | Administrative & support | 2002 |
| THE Cheviot Hotel Ltd | Hospitality | 2026 |
| THE Comb Farmhouse Ltd | Hospitality | 2022 |
| THE Comb Reivers Limited | Hospitality | 2014 |
| THE Common Sense Society | Extraterritorial | 2009 |
| THE Conduit Mead Company Limited | Administrative & support | 2017 |
| THE Cotherstone and Three Chimneys Charity Trustee Limited | Real estate | 2011 |
| THE Customised CAP Company Ltd | Manufacturing | 2022 |
| THE Ecological Living Group Ltd | Wholesale & retail | 2025 |
| THE Elks Head Whitfield Ltd | Hospitality | 2026 |
| THE Feisty FOX - Fine Food Limited | Hospitality | 2022 |
| THE First & Last Brewery Ltd | Wholesale & retail | 2016 |
| THE Fold Farm Vets Limited | Professional & scientific | 2020 |
| THE Forge Cafe Ltd | Hospitality | 2014 |
| THE Granary (Hexham) Management Limited | Households | 1999 |
| THE Grove Newcastle Ltd | Arts & recreation | 2022 |
| THE Halt (Haydon Bridge) Management Company Limited | Households | 2018 |
| THE Heavenly Herb Company Ltd. | Manufacturing | 2016 |
| THE Hextol Foundation | Hospitality | 2006 |
| THE Holms Farm Ltd | Agriculture & fishing | 2022 |
| THE Hungry Herd Limited | Wholesale & retail | 2025 |
| THE International Currency Association Limited | Information & communication | 2016 |
| THE International Optical Technologies Association (Iota) Limited | Other services | 1994 |
| THE Kitchen Works (North East) Limited | Manufacturing | 2003 |
| THE Little Property Company Limited | Real estate | 2013 |
| THE Mental Shift C.I.C. | Information & communication | 2022 |
| THE Milecastle Inn on Hadrian's Wall Ltd | Hospitality | 2022 |
| THE NCS Partnership Limited | Construction | 2002 |
| THE Night Sky Inns Ltd | Hospitality | 2025 |
| THE Northern Centre for Esoteric Studies CIC | Education | 2026 |