| SM Home Improvements & Maintenance Ltd | Administrative & support | 2024 |
| Small Business Consultants Ltd | Professional & scientific | 2025 |
| Small Farms Butchers Ltd | Wholesale & retail | 2021 |
| Small Farms Ltd | Wholesale & retail | 2005 |
| Smart CAB Taxis Ltd | Transport & logistics | 2026 |
| Smart Cone Ltd | Wholesale & retail | 2015 |
| Smartcom Software Ltd | Information & communication | 2005 |
| SME Finance Directors Ltd | Professional & scientific | 2009 |
| SME Hereford Ltd | Administrative & support | 2017 |
| SMH Trading Limited | Wholesale & retail | 2008 |
| Smith Builders Limited | Construction | 2010 |
| Smoke Show Coffee Co. Ltd | Wholesale & retail | 2026 |
| Smoking Boots Limited | Professional & scientific | 2011 |
| Smsc Property Ltd | Real estate | 2021 |
| SMW Property Group Ltd | Real estate | 2016 |
| SN & AC Madge Limited | Health & social care | 2016 |
| Snake Eyes Ltd | Information & communication | 2021 |
| Snowco Investments Ltd | Financial services | 2015 |
| Snowlycode Ltd | Information & communication | 2020 |
| Sobczyk Ltd | Construction | 2018 |
| Sockett Developments Ltd | Construction | 2006 |
| Sockett Holdings Limited | Real estate | 2024 |
| Sockett Properties Ltd | Construction | 2006 |
| Sockett Recovery Ltd. | Transport & logistics | 2023 |
| SOE Clothing Limited | Wholesale & retail | 2014 |
| Sofacine Limited | Information & communication | 2025 |
| Soho Express Ltd | Wholesale & retail | 2024 |
| Soho HFD Ltd | Wholesale & retail | 2026 |
| Solar Fuel Ltd | Construction | 2019 |
| Solar Panel Cleaning Services Ltd | Administrative & support | 2016 |
| Solarkinetics Limited | Energy | 2010 |
| Solarkinetics Properties Limited | Real estate | 2023 |
| Sollars View Ltd | Information & communication | 2025 |
| Solo Consultants Ltd | Information & communication | 2022 |
| Solo INT Property Limited | Real estate | 2013 |
| Solomon Property Developments Limited | Construction | 2006 |
| Solotact Ltd | Wholesale & retail | 2021 |
| Solutions DRS Limited | Construction | 2016 |
| Solutions Engineered Limited | Manufacturing | 2014 |
| Somerset Concrete Pumping Ltd | Construction | 2018 |
| Sonas Farm Services Ltd | Agriculture & fishing | 2024 |
| Sonosense Limited | Health & social care | 2025 |
| SOP. Tech Ltd | Professional & scientific | 2025 |
| Sopjul Limited | Real estate | 2019 |
| Soter Knight Consulting Ltd | Administrative & support | 2019 |
| Soteria Safety Ltd | Professional & scientific | 2007 |
| South East Wales Hang Gliding and Paragliding Club Limited | Arts & recreation | 2004 |
| South Shropshire Scaffolding Services Ltd | Construction | 2014 |
| South Staffs (Farms) Limited | Agriculture & fishing | 1961 |
| South Staffs Farms Holdings Limited | Agriculture & fishing | 1984 |
| South WYE Development Trust Limited | Real estate | 2006 |
| Southcroft Homes Ltd | Real estate | 2021 |
| Southside School of Motoring Limited | Education | 2011 |
| Spacepath Communications Limited | Manufacturing | 2014 |
| Span Design Limited | Construction | 2002 |
| Sparkes Electrical Services (Hereford) Limited | Construction | 2026 |
| Sparrow Automotive Limited | Wholesale & retail | 2016 |
| Sparta Estate Ltd | Real estate | 2026 |
| Sparta Mech Ltd | Construction | 2020 |
| Spartan Plumbing & Heating (Hereford) Ltd | Construction | 2024 |
| SPD Construction Ltd | Construction | 2012 |
| SPD Parts Limited | Wholesale & retail | 2016 |
| Special Marketing Ltd | Professional & scientific | 2023 |
| Special Metals Deutschland Limited | Administrative & support | 1976 |
| Special Metals Services Limited | Administrative & support | 1995 |
| Special Metals Wiggin Limited | Manufacturing | 1892 |
| Specialised Water-Jet Services Limited | Extraterritorial | 2008 |
| Specialised Welding Services Ltd | Manufacturing | 2003 |
| Speech Marks Communications Limited | Professional & scientific | 2012 |
| Speednet International Limited | Transport & logistics | 2001 |
| Spero Investments Group Ltd | Real estate | 2020 |
| Spero Living Limited | Real estate | 2024 |
| Spero Ventures Ltd | Real estate | 2018 |
| Spice Hub Hereford Limited | Hospitality | 2022 |
| Spice World Hereford Limited | Hospitality | 2024 |
| Spilsbury Plumbing and Heating Limited | Construction | 2015 |
| Spin 2 WIN Casino Slots Ltd | Arts & recreation | 2025 |
| Spindrift Associates Limited | Real estate | 2022 |
| Spire Trading Limited | Health & social care | 1994 |
| Spires Property Investment Ltd | Real estate | 2019 |
| SPK Facades Limited | Construction | 2019 |
| Splitlath Limited | Construction | 1999 |
| Splitlath Motorsport Limited | Arts & recreation | 2009 |
| Spokeshave Holdings Ltd | Financial services | 2022 |
| Spoon & Pinch Limited | Wholesale & retail | 2021 |
| Spoor Solutions Ltd | Administrative & support | 2025 |
| Spot on Damp Proofing Ltd | Construction | 2025 |
| Spratz Engineering Ltd | Manufacturing | 2021 |
| Sprayzi Ltd | Wholesale & retail | 2026 |
| Sprees Farm Ltd | Agriculture & fishing | 2023 |
| Spriggs Property Management Limited | Real estate | 2022 |
| SPRING2 Ltd | Professional & scientific | 2023 |
| Springboard Safety Services Limited | Professional & scientific | 2009 |
| Springfield Dwellings Ltd | Real estate | 2025 |
| Springfield Organics Limited | Manufacturing | 2022 |
| Springfield Project Services Limited | Professional & scientific | 2024 |
| Springfield Soft Fruit Limited | Agriculture & fishing | 2013 |
| SQF Ltd | Professional & scientific | 2025 |
| Square Dynamics 2 Limited | Real estate | 2023 |
| Square Dynamics Limited | Administrative & support | 2011 |