| SHA Kish UK Ltd | Wholesale & retail | 2024 |
| Shadowpath Limited | Wholesale & retail | 2020 |
| Shake N Seasons Limited | Hospitality | 2025 |
| Shane Connolly & Co Ltd | Administrative & support | 2011 |
| Shane Connolly Flowers Ltd | Arts & recreation | 2003 |
| Shannon Equestrian Horse Sales Limited | Agriculture & fishing | 2014 |
| Shannon Equestrian Stud Limited | Wholesale & retail | 2017 |
| Shape FM Limited | Real estate | 2017 |
| Shape Residential Ltd | Real estate | 2023 |
| Shaun Conboy Carpentry Ltd | Construction | 2023 |
| Shaun Jones Transport Limited | Transport & logistics | 2024 |
| Shayne Hogg Funeral Services Limited | Other services | 2011 |
| Shayne Hogg Funerals Limited | Other services | 2019 |
| Sheep and Shearful Ltd | Wholesale & retail | 2014 |
| Sheet Solutions Limited | Professional & scientific | 2017 |
| Shell to Rock Limited | Real estate | 2025 |
| Shelwick Properties Ltd | Real estate | 2021 |
| Shelwick Services Limited | Water & waste | 2006 |
| Shepherds Parlour Limited | Hospitality | 2025 |
| Sheppard's Construction Limited | Construction | 2017 |
| Sheppard's Holding Group Ltd | Real estate | 2023 |
| Sheppard's Maintenance Limited | Construction | 2023 |
| Shetton Court Barns Residents Limited | Households | 2022 |
| Shiers Services Ltd. | | 1970 |
| Shift Arts & Wellbeing Ltd | Health & social care | 2022 |
| Shire Catering Limited | Hospitality | 2024 |
| Shire K9 Security Ltd | Administrative & support | 2024 |
| Shire Oak Timber Frames Ltd | Construction | 2021 |
| Shire Play Limited | Arts & recreation | 2017 |
| Shires Cleaning Services Ltd | Households | 2011 |
| Shires GAS Services Limited | Professional & scientific | 2010 |
| SHM (Property) Ltd | Real estate | 2025 |
| Shootfest Hereford C.I.C. | Arts & recreation | 2019 |
| Shooting Reels LLP | | 2017 |
| Shop 73 Limited | Other services | 2011 |
| Shortwood Limited | Real estate | 2026 |
| Shortwood Residential Limited | Real estate | 2026 |
| Side a Creative Ltd | Professional & scientific | 2026 |
| Sideline Division Ltd | Hospitality | 2024 |
| Sidney Phillips Lease & Tenancy Limited | Real estate | 2025 |
| Sidney Phillips Limited | Real estate | 1989 |
| Sigea Ltd | Information & communication | 2024 |
| Sigeric Limited | Real estate | 2008 |
| Sigma Analytics Ltd | Professional & scientific | 2011 |
| Sigma Semiconductor Ltd | Professional & scientific | 2022 |
| Signature Homes and Construction Ltd | Construction | 2007 |
| Signature Interiors Limited | Wholesale & retail | 2012 |
| Signature Joinery (Hereford) Limited | Manufacturing | 2009 |
| Signs and Labels Hereford Ltd | Wholesale & retail | 2006 |
| Signworx Hereford Ltd | Manufacturing | 2021 |
| Silcox Financial Planning Ltd | Professional & scientific | 2023 |
| Silent Dragon Ltd. | Manufacturing | 2024 |
| Silk Route Cuisine Ltd | Hospitality | 2019 |
| Silurian Victuallers Limited | Hospitality | 1974 |
| Silvale Limited | Construction | 1973 |
| Silverfx Limited | Wholesale & retail | 2004 |
| Simbodies Ltd | Professional & scientific | 2008 |
| Simik Ltd | Health & social care | 2020 |
| Simmondsmills LLP | | 2011 |
| Simon Davey Shopfitting (Hereford) Limited | Manufacturing | 2005 |
| Simon Delaney Ltd | Administrative & support | 2023 |
| Simon Warner Consulting Limited | Health & social care | 2016 |
| Simple Design Works Group Ltd | Professional & scientific | 2018 |
| Simples Solution Ltd | Wholesale & retail | 2026 |
| Simpliwifi Limited | Information & communication | 2018 |
| Simply CBD Limited | Manufacturing | 2018 |
| Simply Holdings Limited | Financial services | 2020 |
| Simply House Lettings Ltd | Hospitality | 2018 |
| Simply House Ltd | Construction | 2016 |
| Simply Stunning Interiors Ltd | Wholesale & retail | 2018 |
| Simply Windows Ltd | Construction | 2023 |
| Simpson Drew Limited | Financial services | 2015 |
| Sines Electrical Limited | Construction | 2014 |
| Sing,Laugh,Breathe C.I.C. | Health & social care | 2017 |
| Sintimac Precision Limited | Professional & scientific | 2011 |
| Sirae Limited | Financial services | 2000 |
| Siskin Capital Ltd | Professional & scientific | 2015 |
| Siskin Services Ltd | Administrative & support | 2011 |
| Sisters Catering Limited | Hospitality | 2007 |
| Sisu (Sigley) Limited | Financial services | 2025 |
| Sixteenbynine Design Ltd | Administrative & support | 2016 |
| Sixth Sense Fitness Limited | Arts & recreation | 2005 |
| SJ Threat Solutions Ltd | Professional & scientific | 2021 |
| SJC Services (Hereford) Limited | Administrative & support | 2013 |
| Skinzophrenic Tattoos Limited | Other services | 2013 |
| Skirrid Consultancy Limited | Administrative & support | 2013 |
| SKL Drinks Ltd | Hospitality | 2019 |
| Sky Blue Hereford Limited | Wholesale & retail | 2024 |
| Sky International Group Ltd | Extraterritorial | 2025 |
| Skydrive Ltd | Administrative & support | 2024 |
| Skye Studio Designs Limited | Wholesale & retail | 2026 |
| Skygarden Properties Ltd | Real estate | 2020 |
| Skylon Group Holdings Limited | Financial services | 2022 |
| Skyroots Ltd | Health & social care | 2023 |
| Skytechuk Limited | Professional & scientific | 2026 |
| Slap Happy Plastering Limited | Construction | 2011 |
| Slate-Blue Consulting Limited | Information & communication | 2003 |
| Slfp Ltd | Professional & scientific | 2026 |
| Slsl Limited | Hospitality | 2023 |
| SM Future Homes Ltd | Extraterritorial | 2026 |