| Saltbox Properties Ltd | Real estate | 2020 |
| Saltbox Property Holdings Ltd | Financial services | 2022 |
| Saltbox Stays East Midlands Ltd | Hospitality | 2023 |
| Salvation Fire & Security Ltd | Administrative & support | 2020 |
| SAM 24 HFD Ltd | Wholesale & retail | 2025 |
| SAM Crabtree Ltd | Arts & recreation | 2024 |
| Samanas Ltd | Administrative & support | 2013 |
| Samrw Ltd | Information & communication | 2021 |
| Sams OFF Licence Ltd | Wholesale & retail | 2025 |
| Sandown Drive Residents Company Limited | Households | 1982 |
| Sandra Cooper Limited | Professional & scientific | 2020 |
| Sandwood Mountaineering Ltd | Education | 2014 |
| Sanni Ltd | Health & social care | 2022 |
| Sannicase Ltd | Real estate | 2024 |
| Sapness Farm Limited | Agriculture & fishing | 2013 |
| Sapphire Aesthetics Property Ltd | Real estate | 2017 |
| Sapphire Medical Aesthetics Ltd | Health & social care | 2013 |
| Saracen Distribution Limited | Wholesale & retail | 2010 |
| Saradan Design & Management Ltd | Construction | 2001 |
| Sarah Charnley Ltd | Wholesale & retail | 2021 |
| Sarah Jones Accounts Ltd | Professional & scientific | 2015 |
| Sarah Margaret Franklin Limited | Extraterritorial | 2026 |
| Sargeants Brothers Limited | Transport & logistics | 1990 |
| Sarian Management Company Limited | Households | 2012 |
| Sarp Properties Ltd | Real estate | 2024 |
| Sasa Hivi Solutions Ltd | Administrative & support | 2010 |
| Sash Restoration Co. (Hereford) Ltd. | Construction | 2003 |
| Sauce Connections Limited | Wholesale & retail | 2008 |
| Savage UK NWB LP | | 2015 |
| Saveur DE Provence Limited | Wholesale & retail | 2025 |
| Saville Carriage Company Limited | Wholesale & retail | 1995 |
| Savoir Solutions Ltd | Education | 2025 |
| Saxon Motor Sports Limited | Extraterritorial | 1991 |
| Saxtys Wines Limited | Wholesale & retail | 2007 |
| SB Glass & Glazing Ltd | Construction | 2013 |
| SB Salisbury Ltd | Wholesale & retail | 2021 |
| SBK Risk Advisory Ltd | Professional & scientific | 2026 |
| SBN Logistic Ltd | Transport & logistics | 2026 |
| SC Hygiene Ltd | Health & social care | 2013 |
| SC Joseph Limited | Construction | 1999 |
| Sc&A Holdings Ltd | Financial services | 2023 |
| SCA Construction Ltd | Construction | 2023 |
| Scalari Ltd | Real estate | 2023 |
| Scallywag Pressenteri Ltd | Information & communication | 2023 |
| Scando Service Ltd | Wholesale & retail | 2025 |
| Scenic Stays Herefordshire Ltd | Hospitality | 2020 |
| Schaeffler Vehicle Lifetime Solutions UK Limited | Wholesale & retail | 2021 |
| Scorpion Datacomms Limited | Administrative & support | 2011 |
| Scorpion Tactical Ltd | Arts & recreation | 2016 |
| Scott & Co Developments Ltd | Construction | 2026 |
| Scott & Sons (Hereford) Ltd | Construction | 2005 |
| Scourfield Property Limited | Real estate | 2021 |
| SCP Implemented Ltd | Professional & scientific | 2023 |
| Scrubbers Pro Limited | Administrative & support | 2025 |
| SD Counselling Ltd | Health & social care | 2023 |
| SD Water Services Ltd | Construction | 2021 |
| SE 100-100 Limited | Construction | 2025 |
| Seabourne Gardens Estates Limited | Households | 2009 |
| Seating Contracts Limited | Administrative & support | 2014 |
| Secret Emporium Ltd | Manufacturing | 2025 |
| Secret Homes and Gardens Limited | Administrative & support | 1995 |
| Secundus Limited | Information & communication | 1990 |
| Secure Roots Limited | Information & communication | 2016 |
| Secured Horizons Limited | Administrative & support | 2025 |
| Securitell Limited | Construction | 1995 |
| Security Events Solutions Ltd | Administrative & support | 2013 |
| Sedgely Consulting Limited | Information & communication | 2011 |
| Seekardo International Ltd | Information & communication | 2019 |
| Segui IL TUO Corso Limited | Administrative & support | 2024 |
| Selloil Limited | Wholesale & retail | 1985 |
| Selmach Holdings Ltd | Financial services | 2014 |
| Selmach Machinery Ltd | Wholesale & retail | 2013 |
| Send Nods Clothing Ltd | Wholesale & retail | 2025 |
| Sengalison Limited | Professional & scientific | 2017 |
| Senior Property Solutions Ltd | Real estate | 2018 |
| Sensory & RYE Coworking Limited | Real estate | 2025 |
| Sensory and Bounce Limited | Education | 2025 |
| Sentient Foams Limited | Manufacturing | 2016 |
| Sentinel Security Limited | Wholesale & retail | 1981 |
| Sepaca Limited | Construction | 2018 |
| Separ International Ltd | Administrative & support | 2017 |
| Separ Properties Ltd | Real estate | 2023 |
| Serbus Defence Limited | Information & communication | 2010 |
| Seren Aesthetics Ltd | Other services | 2025 |
| Serendipity Online Marketing Limited | Professional & scientific | 2010 |
| Serene Cottage Property Limited | Real estate | 2025 |
| Serengwyn Consultancy Ltd | Professional & scientific | 2025 |
| Serenity Funeral Services (Hereford) Limited | Other services | 2023 |
| Serenity Property (Hereford) Limited | Real estate | 2024 |
| Servicecentre (UK) Limited | Information & communication | 2014 |
| Servus Management Limited | Administrative & support | 2018 |
| SES Hereford Limited | Construction | 2013 |
| Setfair Ltd | Construction | 2024 |
| Settica Ltd | Administrative & support | 2017 |
| Severn Advisory Limited | Professional & scientific | 2025 |
| SFK Communications Ltd | Information & communication | 2017 |
| Sfs&A Ltd | Professional & scientific | 2026 |
| SFX Consult Limited | Administrative & support | 2015 |
| SG Projects Ltd | Construction | 2014 |
| SGG Project Management Ltd | Construction | 2014 |