| Savaliya Limited | Other services | 2026 |
| Save Time Technology Limited | Information & communication | 2014 |
| Saville Place (Lydiate) Management Company Limited | Households | 2004 |
| Savv Trading Limited | Real estate | 2022 |
| Saxon Dean (Silsden) Management Company Limited | Real estate | 2017 |
| Saxon Gate (Wickwar) Residents Management Company Ltd | Households | 2019 |
| Saxon Heath (Marham Park) Management Company Limited | Real estate | 2021 |
| Saxon Meadows (Standon) Limited | Households | 2018 |
| Saxon Woods Management Company Limited | Households | 2014 |
| SAY Beauty Ltd | Wholesale & retail | 2025 |
| SB Transport Ltd | Transport & logistics | 2025 |
| Sbab Accounting Services Limited | Professional & scientific | 2022 |
| Sbatech Ltd | Information & communication | 2025 |
| Sbjs Construction Ltd | Construction | 2019 |
| SBL Real Estate Limited | Construction | 2024 |
| SBW Group Ltd | Construction | 2019 |
| SC Commercial Services Ltd | Professional & scientific | 2022 |
| SC07YJO Limited | Professional & scientific | 2024 |
| Scaldyeast Ltd | Hospitality | 2025 |
| Scaldylondon Ltd | Hospitality | 2024 |
| Scale & Grow Ltd | Professional & scientific | 2025 |
| Scanlans Consultant Surveyors LLP | | 2009 |
| Scanlans FM Limited | Administrative & support | 2016 |
| Scanlans FRA Limited | Administrative & support | 2016 |
| Scanlans Property Consultants Limited | Professional & scientific | 2016 |
| Scanlans Property Management LLP | | 2009 |
| Scanserve Ltd | Information & communication | 2025 |
| Scansoft Limited | Information & communication | 1998 |
| SCB Trans Ltd | Transport & logistics | 2023 |
| Scdq Limited | Professional & scientific | 2026 |
| Scenic Dunnit Ltd | Arts & recreation | 2022 |
| Scenteur UK Ltd | Wholesale & retail | 2023 |
| Scholars Wynd Management Company Limited | Households | 2005 |
| School of Authentiq Ltd | Information & communication | 2019 |
| Science Supplements Equestrian Ltd | Manufacturing | 2020 |
| Science Supplements Ltd | Manufacturing | 2020 |
| Scientia Guidance Limited | Professional & scientific | 2022 |
| Scight Ltd | Professional & scientific | 2024 |
| Scodal Property Holdings Limited | Financial services | 2018 |
| Scoop Capital Ventures Ltd | Hospitality | 2019 |
| Scorex Limited | Information & communication | 2026 |
| Scorpio Consultancy Limited | Administrative & support | 2018 |
| Scottsdale Overseas Limited | Financial services | 2009 |
| Screen 93 Ltd | Manufacturing | 2012 |
| Scribefort Ltd | Professional & scientific | 2010 |
| Scte Limited | Administrative & support | 1998 |
| SCV Construct Ltd | Construction | 2017 |
| SD Repairs & Maintenance Ltd | Construction | 2025 |
| SE & Co Property Ltd | Real estate | 2019 |
| SE (London) Bar Ltd | Hospitality | 2019 |
| Sea Pickle Ltd | Extraterritorial | 2022 |
| Seabrook Orchards Management Company Limited | Administrative & support | 2016 |
| Sean Hardy Training Ltd | Agriculture & fishing | 2025 |
| Sears & Co Limited | Real estate | 2013 |
| Sears & Co Village and Country Limited | Real estate | 2023 |
| Seatlive Limited | Arts & recreation | 2008 |
| Seatlive Ticketing Services Limited | Arts & recreation | 2010 |
| Seby-Mdy Ltd | Wholesale & retail | 2022 |
| Seckloe 194 Limited | Extraterritorial | 2004 |
| Secuguard Limited | Real estate | 2019 |
| Secured Fencing Ltd | Construction | 2019 |
| Security Everywhere Limited | Other services | 2020 |
| Seda Consulting Limited | Wholesale & retail | 2015 |
| Seddon Property Investments Limited | Real estate | 2016 |
| Seeds Consultants UK Ltd | Professional & scientific | 2015 |
| Seen. by Seleeta Walker Ltd | Professional & scientific | 2026 |
| SEG Core Ltd | Information & communication | 2025 |
| Segmo Ltd | Information & communication | 2026 |
| Segplc.Com Ltd | Construction | 2023 |
| SEI Trading Ltd | Wholesale & retail | 2022 |
| Seismic Venture Partners Limited | Professional & scientific | 2014 |
| Seka Group Limited | Construction | 2026 |
| Select Staffing Group Limited | Other services | 2017 |
| Selecta Finance UK Limited | Financial services | 2020 |
| Selecta U.K. Limited | Hospitality | 1991 |
| Selecta UK Holding Limited | Financial services | 1925 |
| Selective Brands Limited | Administrative & support | 2018 |
| Seline Estates Ltd | Real estate | 2022 |
| Selma Beauty Limited | Other services | 2024 |
| Semmantic Limited | Professional & scientific | 2026 |
| Sendro Ltd | Wholesale & retail | 2013 |
| Sennen Education Ltd | Administrative & support | 2022 |
| Sense Building Controls Limited | Other services | 2009 |
| SEP Gastroenterology Ltd | Health & social care | 2024 |
| Sept Rouges Limited | Extraterritorial | 2016 |
| Sequoia Horticulture Ltd | Administrative & support | 2024 |
| Sercan Limited | Hospitality | 2023 |
| Serck Aviation Limited | Extraterritorial | 1998 |
| Serenity Woodmill Limited | Manufacturing | 2021 |
| Serpologic Ltd | Administrative & support | 2017 |
| Sessionhigh Ltd | Information & communication | 2020 |
| SET Go Transport Ltd | Transport & logistics | 2025 |
| Setelya Estate Limited | Real estate | 2024 |
| Seven Land Investment Ltd | Real estate | 2025 |
| Seven North Investments Ltd | Real estate | 2026 |
| Seven Sites Holdings Ltd | Construction | 2026 |
| SF Exterior Cleaning Ltd | Construction | 2024 |
| SF Miller Limited | Real estate | 2016 |
| SFE Flooring Ltd | Wholesale & retail | 2025 |
| SG Futures Ltd | Financial services | 2024 |