| SGA Rigging Consultancy Film & TV Industry Ltd | Professional & scientific | 2026 |
| SGB CAD Design Ltd | Professional & scientific | 2011 |
| SGI Gardening Limited | Administrative & support | 2024 |
| SH Scaffold Limited | Construction | 2024 |
| Shaan Trading Limited | Hospitality | 2015 |
| Shaarkco Ltd | Administrative & support | 2025 |
| Shabani B Ltd | Construction | 2018 |
| Shade London Ltd | Wholesale & retail | 2025 |
| Shaded Spaces Ltd | Professional & scientific | 2021 |
| Shaft Current Solutions UK Ltd | Professional & scientific | 2024 |
| Shaftesbury Gardens (Acton) Management Company Limited | Households | 1994 |
| Shaggy and Chic Ltd | Professional & scientific | 2015 |
| Shah ENT Ltd | Wholesale & retail | 2026 |
| Shahd GOL Chenaran Food Productions Ltd | Wholesale & retail | 2019 |
| Shain Kebab Ltd | Hospitality | 2026 |
| Shak Estates Ltd | Households | 2026 |
| Shanco IT Services Limited | Information & communication | 2019 |
| Shani Enterprise London Ltd. | Wholesale & retail | 2020 |
| Shanoor Traders UK Ltd | Wholesale & retail | 2024 |
| Shantihealth Ltd | Health & social care | 2022 |
| Shantock Management Company Limited | Real estate | 1994 |
| Shapelifestyle Ltd | Arts & recreation | 2026 |
| Shared Strength Network CIC | Education | 2024 |
| Sharjeel Cars Ltd | Wholesale & retail | 2026 |
| Sharon Rose Integrated Services Ltd | Health & social care | 2011 |
| Sharpe Productions Limited | Information & communication | 2016 |
| Sharpley Investments Limited | Real estate | 1999 |
| Shattered Atlas Ltd. | Manufacturing | 2017 |
| Shaw Spencer International (HK) Ltd | Extraterritorial | 2006 |
| Shazi Traders Ltd | Wholesale & retail | 2021 |
| Sheethanger Lane Residents Limited | Households | 2022 |
| Shefford Inns Ltd | Hospitality | 2024 |
| Shehu Contractors Ltd | Construction | 2022 |
| Shelby Burton Hair Limited | Other services | 2026 |
| Shellwood Consulting Limited | Professional & scientific | 2011 |
| Sheng NUO Limited | Wholesale & retail | 2007 |
| Shenzhen X-Mulong Circuit Co. Ltd. | Administrative & support | 2016 |
| Sherford SL04 Management Company Limited | Households | 2020 |
| Sherington Grange Management Company Limited | Households | 2019 |
| Sherlock Freelance Consulting Ltd | Professional & scientific | 2014 |
| Sherman's Coffee PAD Ltd | Hospitality | 2025 |
| Sherpa House Management Company Limited | Households | 2017 |
| Shift Left Technology Ltd | Professional & scientific | 2022 |
| Shifted Sustainability Ltd | Administrative & support | 2023 |
| Shimmer (Apartments) Management Company Limited | Households | 2011 |
| Shine a Bath Ltd | Construction | 2023 |
| Shinfield Meadows Management Company Limited | Households | 2016 |
| Shining Trading Consultancy Limited | Professional & scientific | 2024 |
| Shire Outdoor Kitchens Limited | Wholesale & retail | 2024 |
| Shire Properties Limited | Real estate | 2018 |
| Shop Vibe AR Ltd | Wholesale & retail | 2025 |
| Shopfromnobody Ltd | Manufacturing | 2025 |
| Shopnexis Limited | Wholesale & retail | 2026 |
| Shoppizar Limited | Wholesale & retail | 2024 |
| Shoreline Bay Studios Ltd | Information & communication | 2025 |
| Shorem Ltd | Public administration | 2022 |
| Short & Co Props Limited | Information & communication | 2014 |
| Shortg Ltd | Manufacturing | 2026 |
| Shoshone Limited | Professional & scientific | 1996 |
| Shottery Apartments (Stratford) Management Company Limited | Households | 2025 |
| Shri Adhya Ltd | Manufacturing | 2025 |
| Shropshire Motorhome Rentals Ltd | Administrative & support | 2023 |
| Shumon Tafadar Limited | Transport & logistics | 2025 |
| Shurland Holdings Limited | Real estate | 2020 |
| Shurville Partners Limited | Professional & scientific | 2020 |
| Shutterhome Ltd | Manufacturing | 2017 |
| SIA Air Solutions Ltd | Manufacturing | 2020 |
| SIA Engineering Services Ltd | Construction | 2016 |
| Sica Trans Ltd | Wholesale & retail | 2016 |
| Sickle & Sons Ltd | Construction | 2026 |
| Sickle Cell Champions CIC | Health & social care | 2013 |
| Siddara Consulting Engineers Ltd | Professional & scientific | 2026 |
| Sidekick Studios London Ltd | Professional & scientific | 2017 |
| Sierra Nova Ltd | Health & social care | 2025 |
| Sign LSL Ltd | Professional & scientific | 2022 |
| Silcolore Ltd | Wholesale & retail | 2026 |
| Silgor Music Limited | Information & communication | 2021 |
| Silk Partnership (Building Surveyors) Limited | Construction | 2022 |
| Silk ROW (Braintree) Management Company Ltd | Households | 2021 |
| Silkmakers Court Management Company Limited | Households | 2022 |
| Silva Shine Cleaning Ltd | Administrative & support | 2025 |
| Silver Holdings Ltd | Other services | 2016 |
| Silver Lining Innovative Management Ltd | Information & communication | 2015 |
| Silverhill Plant Ltd | Construction | 2021 |
| Silverline Motors Ltd | Wholesale & retail | 2025 |
| Silvermine Partners LLP | | 2007 |
| Silverpark Consultants Limited | Professional & scientific | 2000 |
| Silverstone Holdco 5 Limited | Financial services | 2025 |
| Silverstone Hotel Opco Limited | Financial services | 2025 |
| Silverstone Hotel Propco Limited | Financial services | 2025 |
| Silvertree Homes Ltd | Real estate | 2016 |
| Silvertree Lettings Ltd | Real estate | 2022 |
| Silviutrans Ltd | Transport & logistics | 2025 |
| Sima Maintainance Limited | Construction | 2023 |
| Sima Projects Ltd | Construction | 2022 |
| Simba Designs Ltd | Information & communication | 2019 |
| Simian Electric Power Company Ltd | Arts & recreation | 2025 |
| Simitrie Limited | Information & communication | 2017 |
| Simms Carpentry Ltd | Construction | 2016 |
| Simon Christie Limited | Administrative & support | 2007 |