| Spa Group Ltd | Manufacturing | 2018 |
| Spa Mortgages Ltd | Administrative & support | 2017 |
| SPA1N Limited | Extraterritorial | 2020 |
| Space Flight Limited | Extraterritorial | 2011 |
| Space Leeds Ltd | Real estate | 2024 |
| Space PR Limited | Professional & scientific | 2009 |
| Space Trip Ltd | Extraterritorial | 2015 |
| Spacecubed Limited | Construction | 2018 |
| Spaceman Design Studio Ltd | Professional & scientific | 2020 |
| Spaces for Living Limited | Construction | 2015 |
| Spacey Houses Management Company Limited | Households | 2016 |
| Spanishvillas.Gb.Com Limited | Real estate | 2005 |
| Spark Harrogate Ltd | Construction | 2022 |
| Sparkling Bright Window Cleaning LLP | | 2013 |
| Spartan Products Ltd | Wholesale & retail | 2016 |
| Spatial Limited | Extraterritorial | 2008 |
| Special Offer Limited | Extraterritorial | 2012 |
| Specialist Info Limited | Information & communication | 1998 |
| Specialist Property Finance Limited | Financial services | 2019 |
| Specialized Concept Store (Harrogate) Ltd | Wholesale & retail | 2009 |
| Spectacular BID Limited | Professional & scientific | 2023 |
| Spectra Trading Ltd | Wholesale & retail | 2024 |
| Spectre FM Limited | Extraterritorial | 2025 |
| Speedlift Ltd | Transport & logistics | 2020 |
| Spen Lane Apartments Management Company Limited | Construction | 2022 |
| Spencer Brooks Limited | Extraterritorial | 2025 |
| Spencer Facilities Limited | Information & communication | 2026 |
| Spencer Jarvis Limited | Extraterritorial | 2025 |
| Spencer Jordan Limited | Extraterritorial | 2025 |
| Spencer Pride Properties Limited | Real estate | 2014 |
| SPH1NX Limited | Extraterritorial | 2020 |
| Spice Culture Ltd | Hospitality | 2020 |
| Spindrift Photography Ltd | Professional & scientific | 2026 |
| Spinksburn Limited | Real estate | 1990 |
| Spire Bidco Hotels Limited | Professional & scientific | 2010 |
| Spirea Limited | Information & communication | 2015 |
| Spirit of Harrogate (Holdings) Limited | Professional & scientific | 1994 |
| Spitfire Engineering Designs Limited | Manufacturing | 2008 |
| Splat Planet Limited | Manufacturing | 2017 |
| Splendidsuccess Limited | Agriculture & fishing | 1999 |
| SPM Business Solutions Limited | Professional & scientific | 2009 |
| Spofforth Forge Limited | Agriculture & fishing | 2010 |
| Spoilt (Harrogate) Limited | Hospitality | 2020 |
| Sporting Influence Foundation CIC | Other services | 2020 |
| Sporting Influence Limited | Education | 2013 |
| Sports & Prestige (Harrogate) Limited | Wholesale & retail | 2024 |
| Sports Advertising Limited | Extraterritorial | 2011 |
| Sports Values Ltd | Arts & recreation | 2020 |
| Sportsoft (U.K.) Limited | Information & communication | 1997 |
| SPRING2RECRUITMENT Limited | Administrative & support | 2020 |
| Springfield Avenue Flats Limited | Hospitality | 1980 |
| Springfield Farm Business Park Ltd | Real estate | 2020 |
| Springfield Management Harrogate Limited | Administrative & support | 2007 |
| Springwell Holiday Cottages Ltd | Hospitality | 2023 |
| Springwell Holiday Cottages Thirsk Ltd | Real estate | 2024 |
| Springwood Lodges Limited | Hospitality | 2002 |
| Spruce Goose Limited | Extraterritorial | 2012 |
| Spruisty Grange Ltd | Real estate | 2020 |
| Spruisty Hall Farm Limited | Financial services | 2025 |
| SPS Harrogate Limited | Construction | 2014 |
| SPS Traders Ltd | Hospitality | 2025 |
| Spsm Limited | Professional & scientific | 2018 |
| Spurwing Agency Limited | Information & communication | 2020 |
| SPW 2026 Limited | Wholesale & retail | 2026 |
| SPX Architects Limited | Professional & scientific | 2016 |
| Square Feet Limited | Construction | 2004 |
| Square One Consultants Ltd | Professional & scientific | 2025 |
| Squidphysics Ltd | Information & communication | 2024 |
| Squiffle Consulting Limited | Information & communication | 2014 |
| Squiggle Consulting Ltd | Administrative & support | 2018 |
| Squiggle Property Limited | Hospitality | 2023 |
| SRI Business Consulting Ltd | Professional & scientific | 2023 |
| Srvc Limited | Administrative & support | 2010 |
| SSA Architects Limited | Professional & scientific | 2015 |
| SSC Brands Limited | Manufacturing | 1996 |
| SSK Medical Ltd | Real estate | 2013 |
| SSW Rawcliffe Ltd | Wholesale & retail | 2020 |
| ST Aidan's Education Services Limited | Education | 2011 |
| ST Ann's Meadow Limited | Real estate | 2002 |
| ST Dynamics Limited | Administrative & support | 2011 |
| ST George's Road (Harrogate) Development Limited | Construction | 2019 |
| ST George`S Court (Harrogate) Management Company Limited | Real estate | 2009 |
| ST James's Financial Communications Limited | Extraterritorial | 2013 |
| ST Leonards York Limited | Real estate | 2012 |
| ST Marys Walk Flat Management Limited | Households | 2002 |
| ST Paul's Lock Management Company Limited | Households | 2015 |
| ST Peter's Square (Harrogate) Limited | Real estate | 2008 |
| ST. James Court (Harrogate) Management Company Limited | Households | 1986 |
| ST1NG Ltd. | Extraterritorial | 2020 |
| Stables Management Limited | Households | 1995 |
| Staffbase UK Ltd | Information & communication | 2018 |
| Staiano Motor Cycles (Racing) Limited | Wholesale & retail | 1980 |
| Staiano Motor Cycles Limited | Wholesale & retail | 1980 |
| Stainbusters (Yorkshire) Ltd | Administrative & support | 2007 |
| Stainbusters Hygiene Ltd | Administrative & support | 2016 |
| Stainless Banding Limited | Professional & scientific | 2009 |
| Stainless Trustees Limited | Administrative & support | 2023 |
| Stainley Ventures Ltd | Real estate | 2015 |
| Stamford Investment Holdings Limited | Financial services | 2017 |
| Stamp Design Co Ltd | Wholesale & retail | 2020 |