| Skylon FM Ltd | Extraterritorial | 2015 |
| Skyngenuity UK Limited | Wholesale & retail | 2025 |
| Skysure Ltd | Transport & logistics | 2023 |
| Skyward Media Productions Ltd | Information & communication | 2022 |
| Skywell Solutions Limited | Manufacturing | 2014 |
| Slater Walker Partnership Limited | Professional & scientific | 2011 |
| Slaterio Ltd | Hospitality | 2020 |
| SLC Healthcare Ltd | Health & social care | 2018 |
| Slhg Consultancy Limited | Professional & scientific | 2025 |
| Slim JIM Limited | Extraterritorial | 2021 |
| Slingsbys of Harrogate Limited | Hospitality | 2026 |
| Slobba Ltd | Wholesale & retail | 2025 |
| SM1TH Limited | Extraterritorial | 2020 |
| Smale and SON Construction and Leisure Limited | Construction | 2014 |
| Smalley Marsey Rispin Architects Limited | Professional & scientific | 2013 |
| Smart Asset Finance Limited | Financial services | 2023 |
| Smart Business Group (Holdings) Limited | Financial services | 2023 |
| Smart Business Properties Limited | Real estate | 2025 |
| Smart in Gardening Ltd | Administrative & support | 2018 |
| Smart Intelligent for Business Solutions Ltd | Wholesale & retail | 2024 |
| Smart Invoice Finance Ltd | Financial services | 2023 |
| Smart Tech IO Limited | Information & communication | 2024 |
| Smart Yorkshire Limited | Manufacturing | 2025 |
| Smarter Products Ltd | Wholesale & retail | 2026 |
| Smartie Land Ltd | Health & social care | 2021 |
| Smartoys (Harrogate) Limited | Construction | 1960 |
| Smarvio Ltd | Manufacturing | 2024 |
| SMC Medical Ltd | Health & social care | 2023 |
| SMG F.S EOT Limited | Financial services | 2023 |
| SMI Property Developers Ltd | Real estate | 2023 |
| Smiletime Limited | Arts & recreation | 2000 |
| Smith Investments Ltd | Real estate | 2006 |
| Smithers Weekend Limited | Wholesale & retail | 2020 |
| Smiths of Harrogate Limited | Wholesale & retail | 1956 |
| SML Publishing Ltd | Information & communication | 2015 |
| SMR Group Holdings Ltd | Professional & scientific | 2025 |
| SN Resourcing Ltd | Administrative & support | 2026 |
| Snaizeholme Joinery Limited | Construction | 2017 |
| Snapwing Limited | Professional & scientific | 2021 |
| Snatch Ltd | Extraterritorial | 2012 |
| Snax Limited | Extraterritorial | 2011 |
| SNE (UK) Ltd | Professional & scientific | 2014 |
| SNE Consultants Ltd | Professional & scientific | 2024 |
| Snodgrass & Co. Limited | Real estate | 2010 |
| Snooty Frox Limited | Extraterritorial | 2012 |
| Snorto Ltd | Real estate | 2021 |
| Snow Essentials Limited | | 2013 |
| Snow Pharma Ltd | Manufacturing | 2025 |
| Snug Aromatics Ltd. | Wholesale & retail | 2016 |
| Soake Limited | Wholesale & retail | 2018 |
| Soalex Property Limited | Real estate | 2025 |
| Soar & Explore Limited | Administrative & support | 2023 |
| Society of Illustrators, Artists & Designers | Other services | 2003 |
| Softcogs Ltd | Information & communication | 2012 |
| SOH Brands Holdings Limited | Financial services | 2007 |
| Sola Events Limited | Arts & recreation | 2013 |
| Solar Panel Kits UK Ltd | Construction | 2026 |
| Solar Plan Earth Ltd | Financial services | 2025 |
| Solar Plan UK Ltd | Wholesale & retail | 2025 |
| Solar Source Ltd | Extraterritorial | 2023 |
| Sold Simply Ltd | Wholesale & retail | 2020 |
| Solecube Ltd | Wholesale & retail | 2023 |
| Solid Structure Group Ltd | Wholesale & retail | 2024 |
| Solidago Ltd. | Professional & scientific | 2011 |
| Solutios Limited | Information & communication | 2025 |
| Solvent Replacement Limited | Wholesale & retail | 2012 |
| Something WE DO Community Interest Company | Education | 2020 |
| Sonder & Clay Legal Limited | Professional & scientific | 2018 |
| SOPH1E Limited | Extraterritorial | 2016 |
| Sophie Elizabeth Ltd | Professional & scientific | 2026 |
| Sophie's Coffee Shop Limited | Hospitality | 2010 |
| Sorevia Ltd | Construction | 2025 |
| Sota Hairdressing (Malton) Limited | Other services | 2006 |
| Soul Fire Limited | Professional & scientific | 2000 |
| Sound & White Ltd | Arts & recreation | 2020 |
| Sound Safety Advice Ltd | Professional & scientific | 2003 |
| Soundproofing Store Limited | Construction | 2014 |
| Soundsgoodtome Limited | Wholesale & retail | 2023 |
| South Downs Sourdough Ltd | Professional & scientific | 2005 |
| South Drive Property Management Company (Harrogate) Limited | Extraterritorial | 2012 |
| South Drive Property Management Limited | Real estate | 2001 |
| South Grange Ltd | Real estate | 1952 |
| South Otter Limited | Professional & scientific | 2024 |
| South Park Road Management Company Limited | Households | 2020 |
| Southcliffe Court Management Company (North Yorkshire) Limited | Households | 2005 |
| Southern & City Rentals LLP | | 2012 |
| Southern Heritage Limited | Extraterritorial | 2012 |
| Sovana Ltd | Administrative & support | 2024 |
| Sovereign Express Limited | Extraterritorial | 2026 |
| Sovereign Facilities Limited | Extraterritorial | 2026 |
| Sovereign Park (Harrogate) Management Company Limited | Households | 1997 |
| Sowa Harrogate Limited | Wholesale & retail | 2019 |
| Sowerby Gateway Limited | Real estate | 2008 |
| SP Advisors Services Ltd | Professional & scientific | 2025 |
| SP Connections Ltd | Administrative & support | 2019 |
| SP Cost Management Ltd | Professional & scientific | 2013 |
| SP1NKS Limited | Extraterritorial | 2020 |
| SP4R Limited | Extraterritorial | 2020 |
| Spa Cycles Limited | Wholesale & retail | 2007 |
| Spa Financial Planning Ltd | Administrative & support | 2020 |