| Sheckter Group Limited | Extraterritorial | 2026 |
| Sheckter Limited | Extraterritorial | 2026 |
| Sheik of Trade Ltd | Wholesale & retail | 2024 |
| Sheila Morton Property Ltd | Real estate | 2017 |
| Sheilen Consulting Ltd | Professional & scientific | 2021 |
| Sheimer Limited | Households | 1990 |
| Sheldon Bloomfield Limited | Manufacturing | 1991 |
| Shellco 120 Limited | Extraterritorial | 2011 |
| Shelley and Stephen Hall (Sash) Ltd. | Administrative & support | 2016 |
| Shenterprises Publishing Ltd | Information & communication | 2024 |
| Shepherd Space Ltd | Professional & scientific | 2014 |
| Sheraton Swan LLP | | 2009 |
| Sherwood Carving Ltd | Arts & recreation | 2023 |
| Shetland Wool Week Limited | Professional & scientific | 2014 |
| Shift SDD Ltd | Professional & scientific | 2011 |
| Shinay Limited | Other services | 2025 |
| Shine Harrogate Ltd | Wholesale & retail | 2015 |
| Shinnelholm Ltd | Professional & scientific | 2025 |
| Shipping Vision Ltd | Wholesale & retail | 2014 |
| Shireglen Property Limited | Real estate | 1999 |
| Shires Bathrooms Group Limited | Wholesale & retail | 2016 |
| Shires Bathrooms Limited | Financial services | 2019 |
| Shishmanov Cleaning Service Limited | Administrative & support | 2025 |
| Shiver CCD Ltd | Information & communication | 2021 |
| Shop Zonex Limited | Wholesale & retail | 2024 |
| Shope-Keeprs Ltd | Wholesale & retail | 2025 |
| Shoppizone Limited | Wholesale & retail | 2023 |
| Short Stay Harrogate Ltd | Hospitality | 2020 |
| Shrestha Trading &Contracting Co Ltd | Wholesale & retail | 2026 |
| Shutter Appointments Ltd | Professional & scientific | 2023 |
| SI Recruitment Holdings Limited | Financial services | 2026 |
| SI Recruitment Limited | Administrative & support | 2004 |
| Sian Marsh Associates Limited | Professional & scientific | 2016 |
| Sian Rees Chiropractor Limited | Health & social care | 2010 |
| Siblings Fastfood Ltd | Hospitality | 2025 |
| Sidhil Investments Limited | Extraterritorial | 1988 |
| Signpost Logistics Ltd | Professional & scientific | 2011 |
| Signstix Ltd | Information & communication | 2013 |
| Silbirco Limited | Real estate | 2018 |
| Silcra Limited | Construction | 2025 |
| Silk & Cotton Limited | Wholesale & retail | 2017 |
| Silver Street Consulting Ltd | Professional & scientific | 2026 |
| Silverback Developments Limited | Construction | 2014 |
| Silverback Holdings Limited | Financial services | 2018 |
| Silverwings 1 Limited | Construction | 2024 |
| Silverwings 2 Limited | Extraterritorial | 2024 |
| Silverwings 3 Limited | Extraterritorial | 2020 |
| Silverwings Limited | Real estate | 2022 |
| Silwood Financial Ltd | Administrative & support | 2015 |
| Simat Layn for Trade Ltd | Wholesale & retail | 2024 |
| Simon Graeme (MOT) Ltd | Wholesale & retail | 2025 |
| Simon Graeme Limited | Wholesale & retail | 2002 |
| Simonand Ltd | Administrative & support | 2019 |
| Simple Giving Ltd | Administrative & support | 2018 |
| Simplefuel Limited | Wholesale & retail | 2025 |
| Simply Bathrooms of Ripon Limited | Wholesale & retail | 2004 |
| Simpsons Fold Freehold Limited | Real estate | 2012 |
| Sims and Ally Ltd | Administrative & support | 2022 |
| Sinano Property Ltd | Real estate | 2022 |
| Sinclair Morris Limited | Extraterritorial | 2012 |
| Sinfonia of Leeds Limited | Arts & recreation | 2017 |
| Sire Group Ltd | Real estate | 2022 |
| Sirius Education Ltd | Education | 2020 |
| Sirius HKK Limited | Wholesale & retail | 2024 |
| Sirius United Ltd | Information & communication | 2024 |
| Sirtin Limited | Health & social care | 2009 |
| Sisu Central Services Limited | Professional & scientific | 2021 |
| Sitebysimon Limited | Professional & scientific | 2012 |
| Sixty Limited | Extraterritorial | 2012 |
| SJ Gibson Ltd | Health & social care | 2019 |
| SJ Parker Consulting Ltd | Professional & scientific | 2026 |
| SJA Rochdale Limited | Real estate | 2019 |
| Sjazdistributions Ltd | Wholesale & retail | 2026 |
| SJM Joinery UK Limited | Manufacturing | 2004 |
| SJR Property Group Ltd | Real estate | 2026 |
| Skarsgard Limited | Extraterritorial | 2026 |
| Skbmedical Ltd | Health & social care | 2022 |
| Skeema Limited | Information & communication | 2026 |
| Skelwith Limited | Real estate | 2026 |
| Skill + Fire Limited | Professional & scientific | 2011 |
| Skill-Key Ltd | Professional & scientific | 2023 |
| Skillabus CIC | Education | 2020 |
| Skin Tightening Company Ltd | Other services | 2026 |
| Skinnydesign Ltd | Administrative & support | 2010 |
| Skipton Court Management Limited | Real estate | 2002 |
| Skipton Limited | Extraterritorial | 2026 |
| Skipton Management (Harrogate) Limited | Real estate | 2006 |
| Skipton Mill Company Limited(The) | Extraterritorial | 1867 |
| Sky FM Limited | Extraterritorial | 2015 |
| Sky Sure Holdings Limited | Transport & logistics | 2023 |
| Skydrops Events Limited | Wholesale & retail | 2014 |
| Skye Holdings Ltd | Real estate | 2019 |
| Skyeland Limited | Hospitality | 1988 |
| Skyfall Cottage Ltd | Hospitality | 2024 |
| Skyfall Media Productions Ltd | Wholesale & retail | 2026 |
| Skyhill Aviation Ltd | Administrative & support | 2026 |
| Skylark (Yorkshire) Limited | Professional & scientific | 2018 |
| Skyler Limited | Extraterritorial | 2023 |
| Skyline Creative Services Ltd | Real estate | 2022 |
| Skyline Property Services Limited | Construction | 2007 |