| SCORP1ON Limited | Extraterritorial | 2020 |
| Scorpius Consultancy Ltd | Hospitality | 2013 |
| Scott Fisher Roofing Limited | Construction | 2013 |
| Scott Gray Associates Ltd | Administrative & support | 2014 |
| Scotton Homes Limited | Construction | 2019 |
| Scotts Management LLP | | 2021 |
| Scottsdale House Limited | Real estate | 2019 |
| Scottsdale House Management Services Limited | Real estate | 2018 |
| Scratch Digital Ltd | Professional & scientific | 2020 |
| Screen Machine (UK) Ltd | Professional & scientific | 2004 |
| Screenprint Design and Print (Harrogate) Ltd | Manufacturing | 2003 |
| Scroll Lock Studios Ltd | Information & communication | 2025 |
| Scruffy Murphy Limited | Extraterritorial | 2012 |
| Scuflo Ltd | Information & communication | 2021 |
| Scurrah Associates Ltd | Agriculture & fishing | 2023 |
| Scurrah Limited | Real estate | 2022 |
| SCW Conversions Ltd | Wholesale & retail | 2019 |
| SD Consultancy & Management Services Ltd | Professional & scientific | 2013 |
| SDB Property UK Holdings Limited | Real estate | 2025 |
| SDI Construction Ltd | Construction | 2003 |
| SDM Consultants (Manchester) Limited | Professional & scientific | 2018 |
| SDR Harrogate Limited | Wholesale & retail | 2024 |
| Sdrg Consultancy Limited | Professional & scientific | 2019 |
| Sdss Limited | Information & communication | 1994 |
| Sea Dreams Ltd | Real estate | 2024 |
| Sea Forever Limited | Real estate | 2021 |
| Sea Investment Holdings Limited | Financial services | 2018 |
| Seabridge Communications Limited | Information & communication | 1996 |
| Seale Opportunities Limited | Professional & scientific | 2022 |
| Seamus Ltd | Extraterritorial | 2013 |
| Searchant Limited | Administrative & support | 2018 |
| Seascape Limited | Wholesale & retail | 2022 |
| Seaward's Coaches Ltd | Extraterritorial | 2023 |
| Seaward's Tours Ltd | Transport & logistics | 2023 |
| Secondtour Limited | Real estate | 2012 |
| Securi Glaze UK Labour Ltd | Construction | 2018 |
| Securimark Limited | Professional & scientific | 2025 |
| Securitas Limited | Extraterritorial | 2023 |
| Security Solutions Services Limited | Real estate | 1999 |
| Seddon and Davison Limited | Professional & scientific | 2017 |
| SEE a Need Fill a Need Limited | Professional & scientific | 2018 |
| Seelig & Co Limited | Hospitality | 2010 |
| SEJ Consultants Limited | Professional & scientific | 2024 |
| Sekao Holdings Ltd | Financial services | 2025 |
| Select Choice Cleaning Services Ltd | Administrative & support | 2025 |
| Select Choice Community Support Ltd | Health & social care | 2020 |
| Selectconcept Residents Management Limited | Households | 1987 |
| Selectrical Services (Yorkshire) LLP | | 2010 |
| Selfish Monster Limited | Extraterritorial | 2020 |
| Sellvora Trading Ltd | Manufacturing | 2020 |
| Selvaro Ltd | Wholesale & retail | 2021 |
| Sema Developments Ltd | Extraterritorial | 2017 |
| Send IT With Love Limited | Wholesale & retail | 2002 |
| Sense Psychotherapy Ltd | Health & social care | 2023 |
| Sensory Days CIC | Health & social care | 2024 |
| Sensory Integrated Solutions Ltd | Professional & scientific | 2011 |
| Sentimental Limited | Extraterritorial | 2012 |
| Sentry Automation Ltd | Professional & scientific | 2023 |
| Seraphina Lingerie Ltd | Wholesale & retail | 2016 |
| Serene Skin Studio Ltd | Other services | 2025 |
| Serenity Aestetics Ltd | Other services | 2025 |
| Serious Racking Limited | Wholesale & retail | 2025 |
| Serious Sweet Holdings Limited | Manufacturing | 2018 |
| Serko Food Ltd | Hospitality | 2025 |
| Sessay Consulting Limited | Professional & scientific | 2025 |
| SET Square (Harrogate) Limited | Professional & scientific | 2003 |
| Seven Architecture Holdings Limited | Professional & scientific | 2015 |
| Seven Architecture Limited | Professional & scientific | 2006 |
| Seven League Boots Limited | Professional & scientific | 2012 |
| Sexpert Ltd | Extraterritorial | 2015 |
| Sexy DOT COM Ltd | Extraterritorial | 2012 |
| Sexy FM Ltd | Extraterritorial | 2015 |
| Sexy Limited | Extraterritorial | 2022 |
| Sexy Scooters Ltd | Extraterritorial | 2012 |
| SF Data Services Ltd | Information & communication | 2023 |
| SF Psychiatry Ltd | Health & social care | 2025 |
| SFB Event Management Ltd | Administrative & support | 2020 |
| SG Dentures and Repairs Limited | Manufacturing | 2007 |
| SG Frame Ltd | Manufacturing | 2016 |
| Sguk Installations Ltd | Construction | 2023 |
| SH1BA Ltd | Extraterritorial | 2021 |
| Shadwell Landscapes Limited | Construction | 2017 |
| Shakedown North Ltd | Arts & recreation | 2019 |
| Shaki International Group Ltd | Professional & scientific | 2024 |
| Shalimar Harrogate Ltd | Hospitality | 2020 |
| Shalimar Indian Harrogate Ltd | Hospitality | 2026 |
| Shampoo Limited | Extraterritorial | 2011 |
| Shar Ltd | Hospitality | 2025 |
| Shareafrica | Health & social care | 2002 |
| Shareaware Limited | Information & communication | 2026 |
| Sharekte Ltd | Wholesale & retail | 2025 |
| Sharon Moore Limited | Professional & scientific | 2003 |
| Shaw & Jagger Architects Ltd | Professional & scientific | 2010 |
| Shaw Mills Management Company Limited | Households | 1997 |
| Shaw Residential Ltd | Real estate | 2020 |
| Shawbeck Holdings Limited | Professional & scientific | 2021 |
| Shaws Group Limited | Professional & scientific | 2000 |
| Shay Financial Ltd | Professional & scientific | 2008 |
| SHB Dining and Events Ltd | Hospitality | 2024 |
| SHE Talks Growth Ltd | Wholesale & retail | 2025 |