| SAM Major Aesthetics Ltd | Other services | 2013 |
| SAM Rushworth Ltd | Information & communication | 2018 |
| Sam's (Yorkshire) Ltd | Hospitality | 2019 |
| Samandr for Trade Ltd | Real estate | 2021 |
| Samantha Hamp Beauty and Skincare Specialist Ltd | Other services | 2022 |
| SAMM1 Limited | Extraterritorial | 2020 |
| Samson Construction (Harrogate) Limited | Construction | 2018 |
| Samson Developments Limited | Construction | 2026 |
| Samuel Staves Ltd | Wholesale & retail | 2022 |
| Samusa Limited | Wholesale & retail | 2025 |
| SAN Saranda Properties Ltd | Hospitality | 2021 |
| Sand Communications Limited | Information & communication | 2007 |
| Sanda Corporate Projects Limited | Professional & scientific | 1986 |
| Sanda Legal Services Ltd | Professional & scientific | 2011 |
| Sanda Property Holdings Ltd | Real estate | 2021 |
| Sandbeck Electrical Ltd. | Construction | 1974 |
| Sandbender Technology Limited | Manufacturing | 2017 |
| Sandbrooke Limited | Extraterritorial | 2026 |
| Sanders Apartments Limited | Hospitality | 2020 |
| Sanderson Reed Group Limited | Real estate | 2021 |
| Sandhurst Group Limited | Extraterritorial | 2026 |
| Sandhurst Limited | Extraterritorial | 2006 |
| Sandos Pharma UK Ltd | Manufacturing | 2025 |
| Sandpiper Consulting Ltd | Professional & scientific | 2019 |
| Sandringham Limited | Extraterritorial | 2026 |
| Sands Construction (North) Ltd | Construction | 2024 |
| Sands HR Consultancy Limited | Administrative & support | 2025 |
| Sandstone Technology (Europe) Limited | Information & communication | 2002 |
| Sandtoft Properties Limited | Real estate | 1964 |
| Sandwich Deli (Harrogate) Limited | Hospitality | 2013 |
| Sandwith Consulting Ltd | Information & communication | 2024 |
| Sans Souci Style Ltd | Wholesale & retail | 2003 |
| Sanyog IT Solutions Limited | Information & communication | 2024 |
| Sapphire Computing Ltd | Information & communication | 2018 |
| Sara Spencer Ltd | Professional & scientific | 2019 |
| Sarah E Frost Associates Limited | Professional & scientific | 2014 |
| Sarah Gardiner Life Coaching Limited | Professional & scientific | 2020 |
| Sarah LE Brocq Consultancy Ltd | Professional & scientific | 2025 |
| Sarah Ryan Limited | Arts & recreation | 2003 |
| Sarah Stewart Designs Ltd | Professional & scientific | 2025 |
| Sarah Williamson Consulting Limited | Professional & scientific | 2014 |
| Sarahann Jewellers Ltd | Wholesale & retail | 2012 |
| SASK1A Ltd | Extraterritorial | 2020 |
| Sassy KIT Ltd | Wholesale & retail | 2023 |
| Satisfaction Limited | Extraterritorial | 2012 |
| Satnam Partnership Ltd | Construction | 2023 |
| Satori Outsourcing Limited | Administrative & support | 2017 |
| Satram Investments Ltd | Financial services | 2024 |
| Satscan Limited | Information & communication | 2018 |
| Saunders Workplace Associates Limited | Administrative & support | 2024 |
| Sausage Squad Limited | Extraterritorial | 2021 |
| Save the Queensbury Tunnel Limited | Real estate | 2026 |
| Savic Medical Limited | Health & social care | 2020 |
| Saville Consultancy Ltd | Professional & scientific | 2005 |
| Saville Properties Harrogate Ltd | Real estate | 2019 |
| Saville Properties Ltd | Real estate | 2025 |
| Savvas Alexander Ltd | Manufacturing | 2022 |
| Sawan Trading Ltd | Wholesale & retail | 2025 |
| Saxid Limited | Financial services | 2013 |
| Saxon International Limited | Extraterritorial | 2026 |
| Saxton Partners Limited | Professional & scientific | 1999 |
| Saxwood Developments Limited | Construction | 2014 |
| Sayce Sayce Limited | Information & communication | 2025 |
| SB Ipco Ltd | Administrative & support | 2014 |
| SB IT Consulting Limited | Information & communication | 2025 |
| SBD Films Ltd | Information & communication | 2018 |
| Sbfm Group Limited | Financial services | 2013 |
| Sbfm Limited | Administrative & support | 2013 |
| Sbfm Services Limited | Administrative & support | 2014 |
| SBM Residential Limited | Real estate | 2020 |
| SC Care Ltd | Health & social care | 2020 |
| SC Nutrition (UK) Ltd | Wholesale & retail | 2013 |
| SCA Self Storage Holdings Limited | Financial services | 2022 |
| Scale UP Search Ltd | Administrative & support | 2022 |
| Scalerev Limited | Information & communication | 2025 |
| Scanning 4 Planning Limited | Professional & scientific | 2017 |
| Scantrac Systems Limited | Professional & scientific | 2014 |
| Scape Development Management Ltd. | Administrative & support | 2018 |
| Scape Holdco 1 Ltd | Financial services | 2021 |
| Scape Student Limited | Hospitality | 2020 |
| Scape UK Management Ltd. | Administrative & support | 2020 |
| Scarah Bank Limited | Households | 2004 |
| Scarlet Pine Ltd | Real estate | 2023 |
| SCC Prop Co Limited | Real estate | 2023 |
| Scenery Storage Ltd | Transport & logistics | 2024 |
| Schmitz Limited | Wholesale & retail | 2022 |
| SCHO62 Investments Limited | Administrative & support | 2016 |
| Schofield Fitness Ltd | Health & social care | 2018 |
| Schofield Money Advice Limited | Financial services | 2023 |
| Schofield Money Group Limited | Financial services | 2010 |
| Schofield Money Investments Limited | Financial services | 2018 |
| Schofield Money Limited | Financial services | 2004 |
| Schofield Money Planning Limited | Financial services | 2023 |
| Schofields (Yorkshire) Limited | Extraterritorial | 2012 |
| Scholes Capital Unlimited | Professional & scientific | 2025 |
| Scientific Diagnostics Ltd | Professional & scientific | 2025 |
| Scinomed Ltd | Manufacturing | 2008 |
| SCM Virtual Business Solutions Limited | Administrative & support | 2020 |
| Scoff and Quaff Limited | Hospitality | 2023 |
| SCORP1O Limited | Extraterritorial | 2020 |