| Skin by Sarah Limited | Health & social care | 2017 |
| Skin Crypt Ltd | Education | 2025 |
| Skin Sculpt Aesthetics Ltd | Other services | 2016 |
| Skinny Devil UK Ltd | Wholesale & retail | 2012 |
| Skinsciencebymh Ltd | Other services | 2024 |
| Skipton Car Radio Limited | Wholesale & retail | 2015 |
| Skircoat Developments Limited | Real estate | 2012 |
| Skircoat Green Dental Practice Ltd | Health & social care | 2014 |
| Skircoat Green Stores Ltd | Wholesale & retail | 2022 |
| Skircoat Management (2005) Limited | Households | 2005 |
| SKM Direct Ltd | Wholesale & retail | 2023 |
| SKM Tax Specialists Limited | Professional & scientific | 2026 |
| Skmco Ltd | Wholesale & retail | 2024 |
| Skylight Electrical and Lighting Limited | Wholesale & retail | 1989 |
| Skyloom Enterprises Ltd | Wholesale & retail | 2025 |
| SLB Solutions Ltd | Professional & scientific | 2022 |
| Sleep Sector Ltd | Manufacturing | 2025 |
| SLI Services Limited | Administrative & support | 2007 |
| SLJ Partybags & Pocket Money Toys Ltd | Wholesale & retail | 2012 |
| Slopingtactic Limited | Hospitality | 2010 |
| SLR Cardiology Referrals Limited | Professional & scientific | 2019 |
| SLT Education Resourcing Ltd | Administrative & support | 2018 |
| Slum Doctor Project | Health & social care | 2009 |
| SM & SM Medical Ltd | Health & social care | 2025 |
| SM Properties Halifax Ltd | Real estate | 2024 |
| Smart Construction Services Ltd | Construction | 2017 |
| Smart Decor Limited | Construction | 2000 |
| Smart Garage Solutions Limited | Information & communication | 2015 |
| Smart Integration Limited | Wholesale & retail | 2013 |
| Smart Move (Yorkshire) Limited | Real estate | 2019 |
| Smart Spaces (Europe) Limited | Extraterritorial | 2025 |
| Smart Tech Halifax Limited | Wholesale & retail | 2020 |
| Smarter Sales Solutions Ltd | Extraterritorial | 2019 |
| Smartgoparcels Limited | Transport & logistics | 2023 |
| Smartlife Electrical Ltd | Construction | 2021 |
| Smas E-Marketplace Ltd | Wholesale & retail | 2024 |
| Smbclinics Ltd | Health & social care | 2026 |
| SMC Media Ltd | Wholesale & retail | 2014 |
| Smedtec Ltd | Professional & scientific | 2021 |
| SMH Plastics (Yorkshire) Limited | Manufacturing | 2016 |
| SMH Services Limited | Construction | 2017 |
| Smiddy House Property Ltd | Hospitality | 2023 |
| Smile Marketing & Consultancy Limited | Professional & scientific | 2020 |
| Smiley Bullfrog Limited | Information & communication | 2010 |
| Smith & Armitage Builders Limited | Construction | 2016 |
| Smith Brothers Developments Limited | Energy | 2021 |
| Smiths & Sons Creative Limited | Professional & scientific | 2018 |
| Smiths Haulage & Contracting Limited | Transport & logistics | 2012 |
| SMJ AG Direct Limited | Information & communication | 2026 |
| Smoked Incorporated Ltd | Financial services | 2017 |
| Smoked OUT HX Ltd | Wholesale & retail | 2024 |
| Smsholidays Limited | Administrative & support | 2022 |
| Smyle Healthcare Limited | Health & social care | 2023 |
| Snapandcart Limited | Wholesale & retail | 2026 |
| Snip & Snuggle Dog Grooming Ltd | Other services | 2026 |
| Snowflake Media Ltd | Professional & scientific | 2006 |
| SNT Holdings Limited | Professional & scientific | 2008 |
| Soapy Shark Ltd | Administrative & support | 2023 |
| Sobczak Transport Ltd | Transport & logistics | 2021 |
| Soch Limited | Real estate | 2013 |
| Social Bookkeeping Ltd | Administrative & support | 2026 |
| Social Covered Ltd | Information & communication | 2019 |
| Social Haven Ltd | Health & social care | 2020 |
| Social Media Connect Ltd | Professional & scientific | 2023 |
| Socialmedia MAX Ltd | Wholesale & retail | 2021 |
| Soffe Holdings Ltd | Financial services | 2023 |
| Soft Joes Ice Cream Ltd | Hospitality | 2026 |
| Softvion Ltd | Wholesale & retail | 2026 |
| Sohal Property Solutions Ltd | Real estate | 2024 |
| SOI 88 Group Co Ltd | Hospitality | 2024 |
| SOL Villas (UK) Limited | Real estate | 2002 |
| Solar Elec Group Limited | Construction | 2023 |
| Solarflare Solutions Ltd | Wholesale & retail | 2025 |
| SOLARPV23 Limited | Construction | 2022 |
| Solarsport (INT) Limited | Wholesale & retail | 2022 |
| Solo Hair & Beauty Limited | Other services | 2003 |
| Solve Mortgages Ltd | Financial services | 2022 |
| Somma Holdings Ltd | Financial services | 2021 |
| Sonata Property Limited | Real estate | 2025 |
| Sonia Lockwood Surgical Services Ltd | Health & social care | 2014 |
| Sonoco Absorbent Technologies Limited | Extraterritorial | 2001 |
| Sonoco Cores and Paper Limited | Manufacturing | 2004 |
| Sonoco Holdings UK Limited | Professional & scientific | 1999 |
| Sonoco Limited | Manufacturing | 1904 |
| Sonoco Milnrow | Extraterritorial | 2000 |
| Sonoco Packaging Limited | Extraterritorial | 1933 |
| Sonoco Polysack Limited | Extraterritorial | 1988 |
| Sonoco Products Company UK | Extraterritorial | 1993 |
| Sonoco Reels Limited | Extraterritorial | 1934 |
| Sonoco Ventures UK Limited | Extraterritorial | 2001 |
| Sophella Mortgages Limited | Financial services | 2017 |
| Sophia Grace Limited | Real estate | 2001 |
| SOS Scaffolding (Yorkshire) Limited | Construction | 2007 |
| Sota Salon UK Limited | Other services | 2025 |
| Soul-Sp Limited | Real estate | 2024 |
| Soulsby-Lee Ltd | Hospitality | 2022 |
| Source TS Limited | Information & communication | 2026 |
| Sourcexchange Ltd | Other services | 2024 |
| Southall Assistance Ltd | Other services | 2025 |
| Southall Services Ltd | Professional & scientific | 2025 |