| Shay Lane Carpets Ltd | Wholesale & retail | 2022 |
| Shazad Omar Ltd | Professional & scientific | 2012 |
| SHE Connects Network Ltd | Administrative & support | 2025 |
| Sheard Packaging Limited | Real estate | 2025 |
| Sheard Properties Limited | Real estate | 1996 |
| Shears Inn Limited | Hospitality | 2018 |
| Shears Property Limited | Professional & scientific | 2020 |
| Shedl Ltd | Real estate | 2022 |
| Sheerin Bespoke Kitchens Ltd | Wholesale & retail | 2016 |
| Sheets Commercial Cladding Limited | Construction | 2026 |
| Shelf Deli Express Halifax Ltd | Hospitality | 2025 |
| Shelton Fencing Limited | Construction | 2017 |
| Sherprint Ltd | Manufacturing | 2015 |
| Sheryl Moore Media Limited | Professional & scientific | 2013 |
| Shibden Estate Company Limited | Professional & scientific | 2001 |
| Shibden Hall View B&B Ltd | Hospitality | 2025 |
| Shibden Head PRE School (Incl Kids Club) 2018 Limited | Education | 2018 |
| Shibden Properties Limited | Real estate | 2021 |
| Shibden Valley Scrappers Limited | Wholesale & retail | 2014 |
| Shield Financial Solutions Ltd | Financial services | 2018 |
| Shield Lets Ltd | Real estate | 2018 |
| Shift 24/7 Ltd | Transport & logistics | 2024 |
| Shiloh Healthcare Limited | Health & social care | 2015 |
| Shine Consultancy & Training Ltd | Professional & scientific | 2014 |
| Shine Within CIC | Health & social care | 2026 |
| Shirt NO TIE (PUB Co) Ltd | Real estate | 2014 |
| Shivangi Medical Ltd | Health & social care | 2025 |
| Shoe Bootique Ltd | Wholesale & retail | 2014 |
| Shop & Bakery Equipment Limited | Manufacturing | 1973 |
| SHOP4 Phones Ltd | Wholesale & retail | 2025 |
| Shree Dahya Properties Ltd | Real estate | 2025 |
| Shree Ramkrishna Enterprise Limited | Wholesale & retail | 2026 |
| Shrewd Properties Ltd | Real estate | 2005 |
| Shrewdd Ltd. | Professional & scientific | 2002 |
| Shudehill Convenience Store Limited | Wholesale & retail | 2010 |
| Shuss Optics Limited | Wholesale & retail | 2026 |
| Shuub Properties Ltd | Real estate | 2017 |
| SIA (G.B.) Limited | Professional & scientific | 1968 |
| SIA Abrasives Holding Limited | Professional & scientific | 2006 |
| SIA Fibral Limited | Manufacturing | 1988 |
| Sicilian Pizzeria Limited | Hospitality | 2016 |
| Siddal Electrical Ltd | Construction | 2019 |
| Siddal OFF Licence Ltd | Wholesale & retail | 2020 |
| Siddall & Hilton Enterprises Limited | Professional & scientific | 1997 |
| Siddall Medical Limited | Professional & scientific | 2011 |
| Sidhil Group Limited | Professional & scientific | 2015 |
| Sidi Studio Ltd | Professional & scientific | 2020 |
| SIG Printing Limited | Other services | 2012 |
| Sigma Law Limited | Professional & scientific | 2009 |
| Sign Systems (Yorkshire) Limited | Manufacturing | 2007 |
| Signature Resin Floors Ltd | Construction | 2013 |
| Signature Resin Solutions Ltd | Construction | 2025 |
| Silent Mastery Holdings Ltd | Financial services | 2025 |
| Silken Stem Limited | Wholesale & retail | 2024 |
| Silvact Bidco Limited | Financial services | 2023 |
| Silvact Midco Limited | Financial services | 2023 |
| Silver FOX Wines Ltd | Wholesale & retail | 2017 |
| Silverbloom Accessories Ltd | Wholesale & retail | 2026 |
| Silverness Limited | Construction | 2006 |
| Silversbone Strategies Ltd | Wholesale & retail | 2025 |
| Silverwave Consulting Ltd | Wholesale & retail | 2025 |
| Simcore Ltd | Real estate | 2020 |
| Simon Yarker Limited | Construction | 2011 |
| Simple Accounting Limited | Professional & scientific | 2004 |
| Simple Convenience Limited | Wholesale & retail | 2023 |
| Simple Lets Ltd | Real estate | 2023 |
| SIMPLE2LET Ltd | Hospitality | 2014 |
| Simplepurchase Ltd | Wholesale & retail | 2022 |
| Simply Car Sales (UK) Ltd | Wholesale & retail | 2015 |
| Simply Glass Wipe Boards Limited | Manufacturing | 2015 |
| Simply Masala Ltd | Hospitality | 2025 |
| Simply-Delish Limited | Hospitality | 2020 |
| Simprint (Brighouse) Ltd | Manufacturing | 2012 |
| Simprint (Halifax) Ltd | Administrative & support | 2011 |
| Simprint Limited | Manufacturing | 2002 |
| Simpson on Site Services Limited | Manufacturing | 2013 |
| Sincw Limited | Health & social care | 2025 |
| Singles Horizons Limited | Administrative & support | 2019 |
| Siphonic Rainwater Systems (SRS) Ltd | Administrative & support | 2025 |
| Sippin' Limited | Hospitality | 2024 |
| Sirius Financial Systems Group Limited | Information & communication | 2001 |
| Sister Squeeze Limited | Hospitality | 2025 |
| Sistermatic Solutions Limited | Information & communication | 2017 |
| Sisters Home Kitchen Ltd | Manufacturing | 2024 |
| Site Hunter (UK) Limited | Wholesale & retail | 2015 |
| Site Maintain Limited | Construction | 2023 |
| Sitepods Limited | Administrative & support | 2012 |
| Situm Properties Ltd | Real estate | 2017 |
| SIX Star Insulation Limited | Construction | 2012 |
| Sixutilities Ltd | Professional & scientific | 2021 |
| Sizzle Pizza Limited | Hospitality | 2026 |
| SJB Pathology Ltd | Health & social care | 2019 |
| SJE IT Limited | Information & communication | 2008 |
| SJS Consultantcy Ltd | Professional & scientific | 2024 |
| SJW Locks Ltd | Other services | 2023 |
| SK Supplements Ltd | Wholesale & retail | 2025 |
| SKH Machine Removers & SON Ltd. | Transport & logistics | 2023 |
| SKI 1ST Limited | Administrative & support | 1999 |
| Skillshop Limited | Health & social care | 2005 |
| Skin and Health Clinic Ltd | Other services | 2023 |