| Scollan Electrical Ltd | Construction | 2021 |
| Scope Associates Ltd | Professional & scientific | 2026 |
| Scorpicor Ltd | Information & communication | 2026 |
| Scorpion Steel Solutions Limited | Manufacturing | 2020 |
| Scott Quantity Surveying Service Limited | Professional & scientific | 2021 |
| Scouse Petals Florist Limited | Wholesale & retail | 2025 |
| Scrabbenii Limited | Health & social care | 2021 |
| Scribble Stone Inspire Ltd | Manufacturing | 2024 |
| Scribble Stone Masonry Ltd | Manufacturing | 2024 |
| Scribe Solicitors Limited | Professional & scientific | 2022 |
| Scrumptious Bites Limited | Hospitality | 2021 |
| Scsayers Ltd | Information & communication | 2024 |
| SCT Therapy Limited | Health & social care | 2014 |
| Scuba Safaris Ltd | Administrative & support | 2022 |
| SDF Plumbing & GAS Limited | Construction | 2017 |
| SDF Properties Limited | Real estate | 2021 |
| SDO Consultancy Limited | Professional & scientific | 2003 |
| SDS Training and Assessment Limited | Education | 2020 |
| Seal Construction (Yorkshire) Ltd | Construction | 2013 |
| Seal IT UP Ltd | Wholesale & retail | 2020 |
| Sealing Products (Yorkshire) LLP | | 2010 |
| Seas the Day Training Ltd | Education | 2023 |
| Sebastian James Consultancy Ltd | Information & communication | 2013 |
| SEC Excavations Ltd | Mining & quarrying | 2026 |
| Second Generation Printworks Ltd | Other services | 2017 |
| Secozan Healthcare Limited | Health & social care | 2021 |
| Section 8 Limited | Professional & scientific | 2011 |
| Sectornet Limited | Extraterritorial | 1976 |
| Secure Bolting Solutions Limited | Wholesale & retail | 2022 |
| Secure Garages Ltd | Construction | 2021 |
| Secure Window Systems Limited | Wholesale & retail | 2012 |
| Secured Risk Group Limited | Administrative & support | 2015 |
| Secured Risk UK Limited | Arts & recreation | 2013 |
| Securestone UK Limited | Administrative & support | 2026 |
| Sedation Services UK Limited | Health & social care | 2024 |
| Seeky Finders Limited | Administrative & support | 2017 |
| Seemed Internet Pharma Limited | Wholesale & retail | 2019 |
| Seemed Pharma Limited | Wholesale & retail | 2019 |
| Seemed Properties Ltd | Real estate | 2019 |
| SEH Legal Limited | Professional & scientific | 2024 |
| Seiful Ltd | Health & social care | 2024 |
| Selby Administration Services LLP | | 2007 |
| Select Computer Systems Limited | Information & communication | 1988 |
| Select Electrical Contractors Limited | Construction | 2000 |
| Select Keighley Memorials Ltd | Manufacturing | 2022 |
| SELECT2 Limited | Wholesale & retail | 2012 |
| SELECT3 Limited | Professional & scientific | 2012 |
| SELECT4 Limited | Health & social care | 2009 |
| SELECT5 Limited | Wholesale & retail | 2013 |
| Seller AMP Limited | Information & communication | 2019 |
| Sellers & Green Ltd | Wholesale & retail | 2019 |
| Senmonka Charred Design Ltd | Manufacturing | 2026 |
| SENT2PRINT Signs Ltd | Manufacturing | 2018 |
| Seraj Fast Foods Ltd | Hospitality | 2023 |
| Serene Sleep Ltd | Wholesale & retail | 2024 |
| Sereneblisss Ltd | Wholesale & retail | 2025 |
| Serenity Beauty Clinic Limited | Other services | 2012 |
| Serenity Wellbeing Gardens CIC | Agriculture & fishing | 2025 |
| SET in Stone Yorkshire .Co.Uk Ltd | Construction | 2019 |
| Setsquare Architecture Ltd | Professional & scientific | 2019 |
| Seve Productions Ltd | Information & communication | 2011 |
| Seven Four Digital Consulting Limited | Professional & scientific | 2023 |
| Seven INS Limited | Education | 2017 |
| SEW Different Ltd | Arts & recreation | 2023 |
| Seyden Limited | Wholesale & retail | 2017 |
| Seymour Engineering Limited | Manufacturing | 1993 |
| Sfahealthcare Ltd | Health & social care | 2020 |
| SG Day Ltd | Administrative & support | 2015 |
| SG Interiors Couture Ltd. | Wholesale & retail | 2010 |
| SG Plumbing & Heating Services Ltd | Construction | 2021 |
| SG Private Clients Limited | Professional & scientific | 2000 |
| SGB Wealth Limited | Financial services | 2019 |
| Sgpo Limited | Extraterritorial | 2019 |
| SGS Windscreens Ltd | Wholesale & retail | 2012 |
| SH Fire Safety Limited | Administrative & support | 2015 |
| SH Healthcare Limited | Health & social care | 2012 |
| Shadow Brands Ltd | Professional & scientific | 2024 |
| Shadowdust Limited | Wholesale & retail | 2024 |
| Shah E Jilaan Ltd | Administrative & support | 2023 |
| Shaheed Quran & Para Ltd | Other services | 2022 |
| Shahji Group Limited | Hospitality | 2020 |
| Shahstech Ltd | Wholesale & retail | 2026 |
| Shahzadi Eyecare Limited | Health & social care | 2020 |
| Shahzadi Foods Limited | Hospitality | 2025 |
| Shakeel Hamid Consultants Limited | Administrative & support | 2017 |
| Shakil Ahmed Holdings Ltd | Real estate | 2019 |
| Shamim Medical Limited | Health & social care | 2014 |
| Shamraze Hussain Ltd | Extraterritorial | 2014 |
| Shan DEE Inns Ltd | Hospitality | 2025 |
| Sharjeel Ashraf Limited | Professional & scientific | 2024 |
| Sharma Retail Limited | Wholesale & retail | 2007 |
| Sharp Building Services Limited | Professional & scientific | 2021 |
| Sharp Physiotherapy Limited | Other services | 2022 |
| Sharpe Joinery Services Ltd | Manufacturing | 2022 |
| Sharpe Samuels Ltd | Administrative & support | 2024 |
| Sharps Environmental Management Ltd | Water & waste | 2020 |
| Shaw Metal Solutions Ltd | Manufacturing | 2011 |
| Shaw Property Rentals Ltd | Real estate | 2024 |
| Shawford Building Services Ltd | Administrative & support | 2018 |
| Shay Cctv Ltd | Administrative & support | 2025 |