| Sabel Cosmetics Holdings Limited | Financial services | 2009 |
| Sabel Cosmetics Limited | Manufacturing | 1997 |
| Sabey Ltd | Real estate | 2017 |
| Sabre Stairlift Systems Limited | Construction | 1995 |
| Sabria Law Limited | Administrative & support | 2026 |
| Sadik Pharma Ltd | Health & social care | 2025 |
| Safe Storage Logistics Limited | Transport & logistics | 2025 |
| Safe-Scene Security Ltd | Administrative & support | 2023 |
| Safecare Storage Ltd. | Real estate | 2022 |
| Safelinks Security and Recruitment Ltd | Administrative & support | 2019 |
| Safer Journeys Transportation Ltd | Transport & logistics | 2024 |
| Safety Systems Technology UK Ltd | Manufacturing | 2014 |
| Safetyrite Ltd | Education | 2004 |
| Saff Mart Ltd | Wholesale & retail | 2026 |
| Saghir's Properties Ltd | Real estate | 2021 |
| Sahaha Investments Limited | Real estate | 2018 |
| Sahs MR Parmo Ltd | Hospitality | 2025 |
| SAI Health Solutions Ltd | Health & social care | 2024 |
| SAI Leela Ltd | Real estate | 2024 |
| SAI Vivek Vallabh Software Solutions Ltd | Information & communication | 2013 |
| Saim Anwar Ltd | Wholesale & retail | 2025 |
| Sajjad Financial Ltd. | Professional & scientific | 2016 |
| Sakina Enterprise Limited | Professional & scientific | 2003 |
| Sakzo Ltd | Wholesale & retail | 2023 |
| Salaam Drinks Ltd | Wholesale & retail | 2024 |
| Salbee Limited | Professional & scientific | 2020 |
| Salgan Limited | Real estate | 2005 |
| Salmon Cars Ltd | Transport & logistics | 2013 |
| Salon King Limited | Manufacturing | 2013 |
| Salts Mill Taverns Ltd | Hospitality | 2025 |
| Salty Sailors Ltd | Real estate | 2025 |
| SAM Duggan Services Ltd | Other services | 2022 |
| SAM Locke Golf Limited | Arts & recreation | 2018 |
| SAM O'Leary Ltd | Information & communication | 2026 |
| Sama Pharma Ltd | Health & social care | 2024 |
| Samaad Ltd | Real estate | 2024 |
| Samanya Portfolio Limited | Real estate | 2025 |
| Samizee Ltd | Wholesale & retail | 2025 |
| Sampraves Technology Solutions Ltd | Information & communication | 2012 |
| Samson Engineering Ltd. | Wholesale & retail | 2003 |
| Samsung Apple Direct Limited | Wholesale & retail | 2022 |
| Samuel Earnshaw Limited | Real estate | 1969 |
| SAN Jose Properties Limited | Real estate | 1982 |
| SAN Pedro Properties Limited | Real estate | 2000 |
| Sanako UK Limited | Information & communication | 1986 |
| Sanatech Web Services Ltd | Information & communication | 2016 |
| Sandingshed Ltd | Wholesale & retail | 2012 |
| Sandra P Greenwood Consultancy Services Limited | Professional & scientific | 2024 |
| Sandway Cottes Ltd | Wholesale & retail | 2025 |
| Sandwells Construction Limited | Construction | 2003 |
| Sandwells Properties Limited | Real estate | 2017 |
| Sandy Lewart Ltd | Wholesale & retail | 2025 |
| Sangha Halifax Limited | Real estate | 2025 |
| Sanguis Ltd | Real estate | 2016 |
| Sanjay Retail Limited | Wholesale & retail | 2023 |
| Sanne Labs Limited | Information & communication | 2022 |
| Sanne Limited | Manufacturing | 2016 |
| SAP Properties HX Ltd | Real estate | 2025 |
| Sapc Services UK Limited | Construction | 2025 |
| Sapore Bistro Limited | Hospitality | 2019 |
| Saqib Halal Meat Ltd | Wholesale & retail | 2018 |
| Sarah Medical Care Ltd | Health & social care | 2017 |
| Sarah Priestley the Beauty & Holistic Specialist Limited | Other services | 2012 |
| Sarah Taylor Estates Limited | Real estate | 2017 |
| Sarah Underwood Design Ltd | Professional & scientific | 2018 |
| Sarah@Plummet Ltd | Hospitality | 2023 |
| Sarawan Boin Ltd | Hospitality | 2026 |
| Sars Solutions Ltd | Information & communication | 2026 |
| Sarwan Ltd | Wholesale & retail | 2023 |
| Satchel Learning Limited | Education | 2015 |
| Sattar Builders Limited | Construction | 2015 |
| Sault Properties Ltd | Real estate | 2025 |
| Saum Ltd | Wholesale & retail | 2025 |
| Saunders Family Investments Ltd | Financial services | 2020 |
| Savile Heath Management Company Limited | Households | 1984 |
| Savile Hotels (UK) Limited | Extraterritorial | 2014 |
| Savile Park Stores Ltd | Wholesale & retail | 2022 |
| Saville Park Mini Specialists Limited | Wholesale & retail | 2014 |
| SAZ Pizza & Balti House Ltd | Hospitality | 2026 |
| SAZ Solicitors Ltd | Professional & scientific | 2023 |
| SB Skate Ramps Limited | Manufacturing | 2018 |
| SBC Hosting Ltd | Information & communication | 2018 |
| SBG Properties Limited | Real estate | 2012 |
| Sbkc Consulting Limited | Professional & scientific | 2025 |
| SBW Locum Ltd | Professional & scientific | 2022 |
| SBW Property Limited | Real estate | 2025 |
| SC Talent Limited | Professional & scientific | 2025 |
| SCA Productions Ltd. | Arts & recreation | 2025 |
| Scale Model Shop Limited | Other services | 2012 |
| Scalford Central Ltd | Wholesale & retail | 2025 |
| Scanbridge Ltd | Information & communication | 2022 |
| Scandic Halifax Ltd | Hospitality | 2023 |
| Scarlett Sings Ltd | Arts & recreation | 2020 |
| Scentz-Sationz Ltd | Wholesale & retail | 2017 |
| SCH Partnership & Holdings Ltd | Financial services | 2025 |
| Schizuka Motors Limited | Wholesale & retail | 2022 |
| Schneider FM Ltd | Construction | 2026 |
| Schosween 56 Limited | Financial services | 2020 |
| Scientia Talent Ltd | Professional & scientific | 2024 |
| SCM Logistics Limited | Transport & logistics | 2004 |