| Southern & Redfern (Bradford) Ltd | Financial services | 2016 |
| Southern & Redfern Industrial Solutions Limited | Manufacturing | 2006 |
| Southern Cross Investments Group UK Ltd | Real estate | 2017 |
| Sovereign Properties Group Ltd | Real estate | 2025 |
| Sowerby Bridge Fire and Water Ltd | Other services | 2012 |
| Sowerby Bridge Independent Auto Services Limited | Wholesale & retail | 2015 |
| Sowerby Bridge Phones Ltd | Other services | 2024 |
| Sowood Consulting Ltd | Professional & scientific | 2019 |
| Sowood Holdings Limited | Financial services | 2017 |
| Sowood Land Management Ltd | Administrative & support | 2020 |
| SP Plus (Development) Limited | Construction | 2012 |
| SP Sawyer Limited | Construction | 2002 |
| Spa Break Nails Limited | Other services | 2023 |
| Space Club Bradford Ltd | Hospitality | 2025 |
| Spaniard Hall Group Limited | Financial services | 2019 |
| Spaniard Hall Properties Limited | Real estate | 2018 |
| Spaniard Hall Recycling Ltd | Water & waste | 2016 |
| Sparkle Cleaning Services Halifax Ltd | Administrative & support | 2026 |
| Sparsh Retail Ltd | Wholesale & retail | 2022 |
| Sparta Event Crew Limited | Professional & scientific | 2021 |
| Sparta Training Ltd | Administrative & support | 2025 |
| Spartan's Power Distribution Ltd | Transport & logistics | 2022 |
| SPD Assets Limited | Real estate | 2021 |
| Speak Property Limited | Real estate | 2011 |
| Speaks Hire Limited | Administrative & support | 2007 |
| Special Creations Ltd | Wholesale & retail | 2020 |
| Special Valet Limited | Administrative & support | 2026 |
| Specialised Coatings Holdings Limited | Manufacturing | 1999 |
| Specialised Coatings Limited | Manufacturing | 1990 |
| Specialised Coatings UK Limited | Professional & scientific | 2005 |
| Specialised Fabrications Limited | Manufacturing | 2003 |
| Specialised Group Property Holdings Limited | Financial services | 2023 |
| Specialised Group Racing Limited | Administrative & support | 2022 |
| Specialised Group Trading Holdings Limited | Financial services | 2023 |
| Specialised Orthotic Services Limited | Manufacturing | 1994 |
| Specialist Ambulance Service Ltd | Wholesale & retail | 2025 |
| Specialist Periodontal Services Ltd | Health & social care | 2014 |
| Specifi Ltd | Professional & scientific | 2015 |
| Spectre Vehicle Management Ltd | Transport & logistics | 2025 |
| Spectron Solutions Ltd | Extraterritorial | 2015 |
| Spectrum Vehicle Recovery Limited | Real estate | 2001 |
| Speedline Freight Solutions Ltd | Transport & logistics | 2026 |
| Speedy Track Limited | Wholesale & retail | 2024 |
| Speight's Distillery Limited | Wholesale & retail | 2026 |
| Spencer & SON Brick and Stone Work Ltd | Construction | 2022 |
| Spencer Land Ltd | Real estate | 2019 |
| Spencer Roofing Contractors Ltd | Construction | 2020 |
| Spencers Scaffolding Ltd | Construction | 2026 |
| Sphenic Ltd | Information & communication | 2012 |
| SPI North Limited | Transport & logistics | 2010 |
| Spice Delight Restaurant Ltd | Hospitality | 2025 |
| Spinal Care Ltd | Health & social care | 2023 |
| Spindles Wood Turning Limited | Manufacturing | 2016 |
| Spindles Woodturning & Stair Parts Ltd | Construction | 2025 |
| Spine Sage Ltd | Health & social care | 2020 |
| Spine Trading Ltd | Wholesale & retail | 2025 |
| Spinney Withens Ltd | Wholesale & retail | 2025 |
| Spiral Seven Ltd | Wholesale & retail | 2024 |
| Spiralstagelighting Limited | Arts & recreation | 2019 |
| SPL Strategies Limited | Real estate | 2017 |
| Splash Swim Academy Halifax & Huddersfield Ltd | Arts & recreation | 2015 |
| Splash Swim Academy HH LLP | | 2025 |
| Splendid Beds Ltd | Manufacturing | 2024 |
| Sporting and Historical Memorabilia (Book Specialists) Limited | Arts & recreation | 2008 |
| Sportmobility UK Ltd | Extraterritorial | 2011 |
| Sportrack Equestrian Surfaces Limited | Administrative & support | 2024 |
| Sportscorp International Ltd | Manufacturing | 2018 |
| Spot on Concrete (Halifax) Limited | Construction | 2007 |
| Spot on Concrete (Properties) Ltd | Real estate | 2018 |
| Spot on Readymix (Transport) Ltd | Administrative & support | 2018 |
| Spotless Living Cleaning Solutions Ltd | Administrative & support | 2025 |
| Spoton BI Consulting Ltd | Information & communication | 2020 |
| Spots Consulting Limited | Information & communication | 2003 |
| Spray-Tec Halifax Limited | Wholesale & retail | 2014 |
| Sprayform UK Ltd | Wholesale & retail | 2022 |
| Spring Hall Enterprise Ltd | Wholesale & retail | 2021 |
| Spring Hall Group Practice Limited | Health & social care | 2020 |
| Spring Hall Group Properties Ltd | Real estate | 2020 |
| Spring Meadow Services Ltd | Financial services | 2022 |
| Spring Rock Homes Ltd | Real estate | 2016 |
| Springfield Dog Care Ltd | Other services | 2021 |
| Springfield Dog Centre Ltd | Other services | 2024 |
| Springfield Grooming Ltd | Other services | 2026 |
| Springfield Structural Services Ltd | Professional & scientific | 2024 |
| Springhall (Halifax) Limited | Health & social care | 1998 |
| Springhead Funeral Services Limited | Administrative & support | 2017 |
| Springhill Stone Limited | Mining & quarrying | 2005 |
| Springhill Water Services Limited | Water & waste | 2003 |
| Springwell Annie Ltd | Wholesale & retail | 2025 |
| SPS Crime & Investigation Consultancy Ltd | Administrative & support | 2016 |
| SPS IT Technologies Limited | Information & communication | 2026 |
| Sptech Solutions Limited | Information & communication | 2013 |
| Spud HUT Halifax Limited | Hospitality | 2024 |
| Spyd Limited | Transport & logistics | 2018 |
| Squad Cheetah Ltd | Information & communication | 2023 |
| Square Chapel CIC | Arts & recreation | 2020 |
| Square MIX Concrete Ltd | Manufacturing | 2026 |
| SR Pharma Limited | Health & social care | 2012 |
| SRI SAI Associates Limited | Health & social care | 2018 |
| Srileela Ltd | Health & social care | 2021 |