| Elite Security Solutions UK Limited | Construction | 2009 |
| Elite Systems Design Ltd | Construction | 2017 |
| Elite Traders Limited | Manufacturing | 2007 |
| Elite Windows & Conservatories (Grimsby) Limited | Construction | 2012 |
| Elizabeth'Sreal Healthcare Limited | Health & social care | 2015 |
| Eljovic Ltd | Other services | 2011 |
| Ellaby Engineering Limited | Construction | 2007 |
| Ella’S Beauty Lounge Cleethorpes Ltd | Other services | 2025 |
| Ellis Hardware Limited | Wholesale & retail | 2000 |
| Elsfal Limited | Real estate | 1984 |
| Elston Medical Consultancy Limited | Health & social care | 2016 |
| Elvara Lettings Limited | Real estate | 2020 |
| Elvin Design Ltd | Professional & scientific | 2017 |
| Elwicks Ltd | Construction | 2010 |
| EM Fabrications Ltd | Manufacturing | 2023 |
| Embero Ltd | Wholesale & retail | 2026 |
| Embers IT Ltd | Information & communication | 2018 |
| Embley Builders Limited | Construction | 2006 |
| EMC Education Consulting Ltd | Education | 2022 |
| Emcas Care Group Ltd | Health & social care | 2024 |
| Emcas Holdings Ltd | Health & social care | 2023 |
| Emcas Lincolnshire Ltd | Health & social care | 2008 |
| Emilia Holdings Limited | Real estate | 2024 |
| Emilia's Clothing Boutique Ltd | Wholesale & retail | 2019 |
| Emily DEE Ltd | Information & communication | 2015 |
| Emily Fazackerley Limited | Arts & recreation | 2016 |
| Eminiki Ltd | Professional & scientific | 2014 |
| Emlg-Dent Ltd | Health & social care | 2025 |
| Emma Collins Aesthetics Limited | Other services | 2020 |
| Emma Ellse Ltd | Professional & scientific | 2016 |
| Emma Patglobal Limited | Professional & scientific | 2016 |
| Emosa Limited | Professional & scientific | 2022 |
| Empath Employment Pathway Limited | Health & social care | 2026 |
| Emph Lincs Limited | Construction | 2021 |
| Empower-Employability Mentoring Programme Community Interest Company | Administrative & support | 2012 |
| Empress Heating Limited | Construction | 2024 |
| Emps Consultancy Ltd | Administrative & support | 2015 |
| Emsley Property Group Ltd | Real estate | 2026 |
| EMT Building Solutions Limited | Construction | 2017 |
| Encompass Marine Holdings Limited | Wholesale & retail | 2017 |
| Encompass Marine Limited | Wholesale & retail | 2000 |
| Encompass Marine Solutions Limited | Professional & scientific | 2024 |
| Encompass Marine UK Holdings Limited | Financial services | 2019 |
| Endeka Procurement Services Limited | Professional & scientific | 2018 |
| Energy Park Catering Ltd | Hospitality | 2023 |
| Engcon Management Services Ltd | Professional & scientific | 2019 |
| Engine Carbon Management (GY) Ltd | Transport & logistics | 2021 |
| Engine Masters Solutions Ltd | Wholesale & retail | 2023 |
| Engineer Box Limited | Information & communication | 2023 |
| Engineering Integration & Site Solutions Ltd | Construction | 2022 |
| Englezu Ionut Codrut Ltd | Transport & logistics | 2022 |
| Ensco 1330 Limited | Financial services | 2019 |
| Ensco 1331 Limited | Financial services | 2019 |
| Enviro (GY) Limited | Water & waste | 2003 |
| Enviro Holdings Limited | Financial services | 2023 |
| Enviroscan Limited | Professional & scientific | 1997 |
| Envision Fitness Limited | Arts & recreation | 2024 |
| Envy Gowns (Bridal) Limited | Wholesale & retail | 2025 |
| Enzo Direct Limited | Construction | 2026 |
| EPB Solutions Ltd | Professional & scientific | 2024 |
| EPC Retro Limited | Construction | 2024 |
| Equalgrade Holdings Limited | Financial services | 2018 |
| Equalgrade Limited | Other services | 2000 |
| ER Property (Services) Limited | Construction | 2012 |
| ERA Employment CIC | Administrative & support | 2024 |
| Ernie Becketts Limited | Hospitality | 2002 |
| Erris Court Management Company Limited | Households | 2023 |
| ERS Fisheries Ltd | Wholesale & retail | 2021 |
| ES Industrial Cleaning Limited | Administrative & support | 2016 |
| ES Woods Consultancy Ltd | Professional & scientific | 2026 |
| ESA Recycling Limited | Water & waste | 2023 |
| ESL Grimsby Limited | Construction | 2015 |
| ESM Medical Limited | Health & social care | 2013 |
| Esnad Africa OIL Operations UK Limited | Mining & quarrying | 2023 |
| Espersen UK Limited | Administrative & support | 2012 |
| Espindola Ltd | Arts & recreation | 2017 |
| ESS Renovations Ltd | Construction | 2018 |
| ESS Systems Limited | Manufacturing | 2010 |
| Essential Fleet Support Limited | Manufacturing | 2021 |
| Essential to BE Seen Ltd | Professional & scientific | 2024 |
| Essential Wiring Solutions Limited | Construction | 2015 |
| Essentially Coffee Ltd | Manufacturing | 2019 |
| Essex Eco Lofts Ltd | Construction | 2018 |
| Establish-Id Limited | Professional & scientific | 2022 |
| Estateindex Limited | Construction | 1994 |
| Estelle EAR Piercing Limited | Manufacturing | 2003 |
| Estoy Limited | Professional & scientific | 2009 |
| Etch on Glass Ltd | Other services | 2019 |
| Ethan Dobson Limited | Professional & scientific | 2026 |
| Etherington Healthcare Ltd | Health & social care | 2026 |
| Ethical Recruitment Agency (Grimsby) Limited | Health & social care | 2019 |
| Eukasia Ltd | Information & communication | 2015 |
| Euro Express (Grimsby) Limited | Wholesale & retail | 2018 |
| Euro Supermarket Grimsby Ltd | Wholesale & retail | 2025 |
| Euro Terminal Limited | Transport & logistics | 1992 |
| Eurofusion Ltd | Professional & scientific | 2008 |
| Eurogreen Technical Consultants Ltd | Professional & scientific | 2026 |
| Eurolec Services Limited | Manufacturing | 1990 |
| Europa Way Trailer Services Limited | Wholesale & retail | 2002 |
| European Market Grimsby Ltd | Wholesale & retail | 2024 |