| Sarhang Barber Limited | Other services | 2021 |
| Sarvaa Creations Ltd | Wholesale & retail | 2019 |
| Sarvaa Holdings Ltd | Wholesale & retail | 2024 |
| Sasi 2 Thai Ltd | Hospitality | 2024 |
| Sathi Holdings Ltd | Construction | 2023 |
| Satin & SOX Ltd | Wholesale & retail | 2024 |
| Satnam Services Limited | Construction | 2017 |
| Saturn Transport Limited | Transport & logistics | 2022 |
| Saucy Dough Gravesend Ltd | Hospitality | 2025 |
| Saucy Dough Kent Ltd | Hospitality | 2025 |
| Saucy Slice Pizza Ltd | Hospitality | 2025 |
| Saucy Sliders Ltd | Hospitality | 2025 |
| Savdora UK Limited | Construction | 2008 |
| Save on Mini Mart Ltd | Wholesale & retail | 2022 |
| Save UP Ltd | Wholesale & retail | 2025 |
| Saver Foods Limited | Hospitality | 2022 |
| Saviany Ltd | Wholesale & retail | 2017 |
| Savicope Limited | Administrative & support | 2017 |
| Savvy Loan Products Limited | Financial services | 2013 |
| Savvy Skills Ltd | Education | 2025 |
| Saxon Jointing Services Ltd | Construction | 2012 |
| Saxon Park NO.5 Residents Company Limited | Households | 1991 |
| SAY IT Loud Trades Limited | Real estate | 2026 |
| SB Marketing Enterprises Ltd | Professional & scientific | 2025 |
| SB Prestige Properties Ltd | Real estate | 2023 |
| SB Signs and Graphics Ltd | Construction | 2022 |
| SB Stokes Property Investment Limited | Real estate | 2024 |
| SB Wellington Care Limited | Health & social care | 2014 |
| SBA Kent Ltd | Hospitality | 2023 |
| Sbabzy Limited | Information & communication | 2014 |
| SBC Speed Ltd | Transport & logistics | 2020 |
| SC Carmen Ltd | Transport & logistics | 2026 |
| Scadbury Farm Limited | Extraterritorial | 2015 |
| Scafpad Ltd | Construction | 2025 |
| Scaling Offers Ltd | Professional & scientific | 2024 |
| Scalphouse Ltd | Other services | 2020 |
| Scene One Ltd | Information & communication | 2023 |
| Scented by Strelley Ltd | Wholesale & retail | 2025 |
| Schemerr Intelligence Labs Ltd | Information & communication | 2026 |
| Schoolgecko Limited | Education | 2023 |
| Schooner Park Crossways Limited | Households | 2017 |
| SCJ Transport Limited | Transport & logistics | 2008 |
| Sclk Ltd | Information & communication | 2014 |
| Scofield Limited | Wholesale & retail | 2024 |
| Scorpion Security TCL Ltd | Administrative & support | 2018 |
| Scott Contracting Ltd | Wholesale & retail | 2021 |
| SCP Resource Consulting Ltd | Professional & scientific | 2025 |
| Scratch Aesthetics Ltd | Other services | 2020 |
| SCREENS4US Limited | Manufacturing | 2016 |
| Screenscope Ltd | Information & communication | 2025 |
| Scriptcore Limited | Information & communication | 2026 |
| Scrub Masters Cleaning Service Ltd | Administrative & support | 2026 |
| Scrum Consultants Ltd | Information & communication | 2023 |
| SCS Frost Ltd | Construction | 2014 |
| Sculpture Aesthetics Limited | Health & social care | 2018 |
| Scurtu Mihai Ltd | Transport & logistics | 2013 |
| Scvpa Ltd | Administrative & support | 2025 |
| SDB Electrical Services Limited | Construction | 2018 |
| SDR PVT Limited | Wholesale & retail | 2025 |
| SE Bookkeeping & Accountancy Ltd | Professional & scientific | 2024 |
| Seacon Terminals Limited | Transport & logistics | 1981 |
| Seacon Transport Limited | Transport & logistics | 1974 |
| Seaford Security Services Limited | Administrative & support | 2026 |
| Sealand Takeaway Ltd | Hospitality | 2025 |
| Sealeys Estate Agents Limited | Real estate | 2000 |
| Search Beyond Ltd | Administrative & support | 2024 |
| Search Sava Limited | Information & communication | 2018 |
| Searle Contractors Ltd | Energy | 2014 |
| Seasoned Baitz Ltd | Manufacturing | 2025 |
| Sebastian K&K Limited | Transport & logistics | 2017 |
| Sebtrans Logistics Ltd | Transport & logistics | 2018 |
| Second Glance Limited | Wholesale & retail | 2015 |
| Second Heathlands Management Company (Crayford) Limited | Households | 1989 |
| Securejoin Property Management Limited | Households | 1999 |
| Securelec Ltd | Energy | 2013 |
| Securo K9 Ltd | Administrative & support | 2022 |
| Secusafe Ltd | Administrative & support | 2023 |
| Sedot Consult Limited | Professional & scientific | 2014 |
| Seema's Beauty Bar Ltd | Other services | 2019 |
| Seethakumarvel Limited | Health & social care | 2013 |
| Seia Consulting Limited | Professional & scientific | 2019 |
| Seiko Ltd | Wholesale & retail | 2021 |
| Seko Transport Ltd | Transport & logistics | 2019 |
| Selahcinar Limited | Hospitality | 2023 |
| Selasi Professional Services Ltd | Professional & scientific | 2025 |
| Select Alarm UK Limited | Administrative & support | 2010 |
| Select Building Services Limited | Construction | 2006 |
| Select Estates Ltd | Real estate | 2011 |
| Select Sphere Ltd | Wholesale & retail | 2024 |
| Self-Adhesive Materials (UK) Limited | Wholesale & retail | 2002 |
| Sellgoe Health Care Services Ltd | Health & social care | 2024 |
| Sema Cargo Limited | Transport & logistics | 2018 |
| Sematec Limited | Professional & scientific | 2026 |
| Semec Engineering Limited | Construction | 1986 |
| Semilore IT Ltd | Information & communication | 2025 |
| Semperfly Ltd | Transport & logistics | 2019 |
| Sense Quantity Surveyors Limited | Professional & scientific | 2013 |
| Sensecheck Studio Ltd | Information & communication | 2026 |
| Sensei Trans Ltd | Transport & logistics | 2019 |
| Sentinel Alarms Limited | Manufacturing | 2025 |